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Application of geum japonicum thumb extract in preparation of drugs controlling liver and kidney diseases

A technology of extract and blue cloth, which is applied in the field of medicine, can solve the problems of not being able to provide pathological lesions, and achieve the effects of preventing and alleviating chemical liver damage, restoring liver function, and promoting repair

Pending Publication Date: 2020-04-10
伊阿索生物技术(上海)有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Currently available treatments for liver disease are mostly supportive and symptomatic and do not provide treatments that can ameliorate the pathology

Method used

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  • Application of geum japonicum thumb extract in preparation of drugs controlling liver and kidney diseases
  • Application of geum japonicum thumb extract in preparation of drugs controlling liver and kidney diseases
  • Application of geum japonicum thumb extract in preparation of drugs controlling liver and kidney diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] This embodiment provides a kind of preparation method of blue cloth positive extract, and it comprises the following steps:

[0047] (1) In August, the blue cloth was collected from Guizhou Province, China, and the blue cloth was ventilated and dried in the shade for future use.

[0048] (2) Take 10 kg of the blue cloth after the above treatment and place it in 50 L of 60% methanol aqueous solution for soaking and extraction for 3 hours, and repeat the above steps 4 times, and combine the extracts to obtain the alcohol extract.

[0049] (3) Put the above alcohol extract at 40° C. for constant temperature and reduced pressure concentration treatment, and then spray drying treatment to obtain solid powder.

[0050] (4) Dissolve the above solid powder in 10L of water, first extract with 10L of petroleum ether, and remove the petroleum ether extract, then extract with 10L of ethyl acetate, remove the ethyl acetate extract, and then use 10L of n-propanol was extracted to obta...

Embodiment 2

[0053] This embodiment provides a kind of preparation method of blue cloth positive extract, and it comprises the following steps:

[0054] (1) In August, the blue cloth was collected from Guizhou Province, China, and the blue cloth was ventilated and dried in the shade for future use.

[0055] (2) Take 10 kg of the blue cloth after the above treatment and place it in 70 L of 80% n-propanol aqueous solution for soaking and extraction for 3 hours, and repeat the above steps for 5 times, and combine the extracts to obtain the alcohol extract.

[0056] (3) Put the above alcohol extract at 60° C. for constant temperature and reduced pressure concentration treatment, and then perform spray drying treatment to obtain solid powder.

[0057] (4) Dissolve the above solid powder in 10L of water, first extract with 10L of petroleum ether, and remove the petroleum ether extract, then extract with 10L of ethyl acetate, remove the ethyl acetate extract, and then use 10L of n-butanol was ex...

Embodiment 3

[0060] This embodiment provides a kind of preparation method of blue cloth positive extract, and it comprises the following steps:

[0061] (1) In August, the blue cloth was collected from Guizhou Province, China, and the blue cloth was ventilated and dried in the shade for future use.

[0062] (2) Take 10 kg of the blue cloth after the above treatment and place it in 60 L of 70% ethanol aqueous solution for soaking and extraction for 3 hours, repeat the above steps 5 times, combine the extracts to obtain the alcohol extract.

[0063] (3) Put the above alcohol extract at 50° C. for constant temperature and reduced pressure concentration treatment, and then perform spray drying treatment to obtain solid powder.

[0064] (4) Dissolve the above solid powder in 10L of water, first extract with 10L of petroleum ether, and remove the petroleum ether extract, then extract with 10L of ethyl acetate, remove the ethyl acetate extract, and then use 10L of n-butanol was extracted to obta...

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Abstract

Belonging to the technical field of medicines, the invention discloses application of a geum japonicum thumb extract in preparation of drugs controlling liver and kidney diseases. The preparation method of the geum japonicum thumb extract includes the steps of: soaking geum japonicum thumb in an aqueous solution of first alcohol for extraction to obtain an alcohol extracted solution; carrying outvacuum concentration treatment on the alcohol extracted solution, and then conducting spray drying treatment to obtain solid powder; dissolving the solid powder in water, firstly performing extractionby C6 alkane, removing C6 alkane extract liquor, then conducting extraction with ethyl acetate, and removing ethyl acetate extract liquor, and then performing extraction by second alcohol to obtain alcohol extract liquor; and carrying out reduced pressure drying on the alcohol extract liquor, and then sequentially conducting freeze drying and grinding treatment to obtain the geum japonicum thumbextract. The geum japonicum thumb extract has remarkable prevention and treatment effects on hepatitis, hepatic fibrosis, fatty liver, liver cirrhosis, portal hypertension, liver failure, liver and kidney degeneration and other liver and kidney diseases.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to the application of bluebud extract in the preparation of medicines for preventing and treating liver and kidney diseases. Background technique [0002] The liver is an important internal organ that plays a very important role in many important synthesis, metabolism and removal of metabolic waste in the body, including digestion, protein synthesis and detoxification. The liver is an essential organ for human survival, however, it is also very susceptible to disease. Liver disease refers to all potential diseases that can lead to liver dysfunction, including hepatitis, liver disease caused by alcohol abuse, fatty liver, liver fibrosis, cirrhosis, portal hypertension, liver failure, liver cancer, etc. Some patients with liver disease may not show any symptoms, while others with liver disease show jaundice, nausea, vomiting, loss of appetite, dark urine, abdominal distention due to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/73A61P13/12A61P1/16
CPCA61K36/73A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61P1/16A61P13/12
Inventor 李明
Owner 伊阿索生物技术(上海)有限公司
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