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Application of traditional Chinese medicine composition in preparation of medicine for improving gastrointestinal functions and regulating intestinal flora

A technology for regulating intestinal flora and gastrointestinal function, applied in drug combinations, plant/algae/fungus/moss ingredients, pharmaceutical formulations, etc. , to achieve the effect of improving the structure of intestinal flora, improving appetite and relieving anorexia

Pending Publication Date: 2020-04-21
GUANGDONG LITAI PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Modern pharmacological studies have shown that these drugs have anti-inflammatory, antibacterial, analgesic, immune-regulating, anti-fatigue, anti-endothelial cell damage, expectorant, antispasmodic effects, but whether they affect the neuroendocrine system, intestinal flora microecology and There are few studies on the specific mechanism of invigorating the spleen and eliminating food
[0005] There are many traditional Chinese medicines for the treatment of digestive system diseases, but there are few studies on the specific mechanism of their pleiotropic effects. Therefore, according to the physiological characteristics of children, combined with the interpretation of traditional Chinese and Western medicine for digestive system diseases, the mechanism of drugs to improve digestion and treat digestive system dysfunction is studied. It is of great social significance and economic value to research and develop a comprehensive traditional Chinese medicine composition that can regulate the function of the digestive system

Method used

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  • Application of traditional Chinese medicine composition in preparation of medicine for improving gastrointestinal functions and regulating intestinal flora
  • Application of traditional Chinese medicine composition in preparation of medicine for improving gastrointestinal functions and regulating intestinal flora
  • Application of traditional Chinese medicine composition in preparation of medicine for improving gastrointestinal functions and regulating intestinal flora

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Preparation of oral solution:

[0032] (1) Take 66.7g of Astragalus membranaceus, 33.4g of fried Atractylodes macrocephala, 33.4g of tangerine peel, 66.7g of Ophiopogon japonicus, 33.4g of baicalin, 33.4g of fried hawthorn, and 33.4g of fried radish; decoct twice for 2 hours each time, filter, Combine the filtrates and concentrate to a clear paste with a relative density of 1.01 to 1.05 (measured at 60°C);

[0033] (2) Refrigerate for 48 hours, filter to obtain the filtrate;

[0034] (3) Add 300g of refined honey and 0.67g of potassium sorbate (add appropriate amount of water to dissolve) in the filtrate, add water to 1000ml, shake well, let stand for 48 hours, take the supernatant, and filter;

[0035] (4) potting, sterilization, to obtain.

Embodiment 2

[0037] Preparation of oral solution:

[0038] (1) Take 66.7g of Astragalus membranaceus, 33.3g of fried Atractylodes macrocephala, 33.3g of tangerine peel, 66.7g of Ophiopogon japonicus, 33.3g of baicalin, 33.3g of fried hawthorn, and 33.3g of fried radish; decoct twice with water, 2 hours each time, filter, Combine the filtrates and concentrate to a clear paste with a relative density of 1.01 to 1.05 (measured at 60°C);

[0039] (2) Refrigerate for 48 hours, filter to obtain the filtrate;

[0040] (3) Add 300g of refined honey and 0.5g of sorbic acid (add appropriate amount of water to dissolve) in the filtrate, add water to 1000ml, shake well, let stand for 48 hours, take the supernatant, and filter;

[0041] (4) potting, sterilization, to obtain.

Embodiment 3

[0043] Preparation of oral solution:

[0044] (1) Take 53.36kg of astragalus, 26.64kg of fried Atractylodes macrocephala, 26.64kg of tangerine peel, 53.36kg of Ophiopogon japonicus, 26.64kg of scutellaria baicalensis, 26.64kg of fried hawthorn, and 26.64kg of fried radish; add water to extract the above seven flavors three times, the first time for 3 hours, For the second and third times each for 2 hours, combine the decoction, filter, and concentrate the filtrate to a clear paste with a relative density of 1.01 to 1.05 (measured at 60°C);

[0045] (2) Refrigerate for 48 hours, filter to obtain the filtrate;

[0046] (3) Add 240 kg of refined honey to the filtrate of step (2), 0.4 kg of sorbic acid (add appropriate amount of water to dissolve), adjust the total amount to 800000 ml with water, stir well, leave standstill for 48 hours, take the supernatant, and filter;

[0047] (4) potting, sterilization, to obtain.

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Abstract

The invention discloses an application of a traditional Chinese medicine composition in preparation of a medicine for improving gastrointestinal functions and regulating intestinal flora. The traditional Chinese medicine composition comprises the following components: astragalus membranaceus, fried atractylodes macrocephala koidz, pericarpium citri reticulatae, radix ophiopogonis, scutellaria baicalensis, fried hawthorn and fried semen raphani. According to the invention, gastrointestinal hormones and neuropeptides related to appetite can be regulated, so that the microecology of intestinal flora is improved, digestive system diseases which are caused by diet and mainly characterized by dyspepsia are treated and prevented, the general physical sign state of infants is improved, anorexia, abnormal defecation and other symptoms are relieved, the enzyme activity in the intestinal tract is improved, digestion and absorption are promoted, and the nutritional level of organisms is further improved.

Description

technical field [0001] The invention relates to a new application of a traditional Chinese medicine composition, in particular to an application of a traditional Chinese medicine composition in preparing medicines for improving gastrointestinal function and regulating intestinal flora. Background technique [0002] According to the "2015 China Health and Family Planning Statistical Yearbook", the prevalence of digestive system diseases ranks fourth in the prevalence of chronic diseases in my country and ranks among the top. According to incomplete statistics, on a global scale, the total incidence of digestive system diseases accounts for 30% of the population, and the number of deaths due to digestive system diseases accounts for 14% of the total death toll. Due to the immature development of the digestive system organs of young children, the two major functions of digestion and absorption are relatively weak, coupled with improper feeding by parents, children's diet is irr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/8968A61P1/14A61P1/00A61P1/12
CPCA61K36/284A61K36/31A61K36/481A61K36/539A61K36/734A61K36/752A61K36/8968A61K2236/331A61P1/00A61P1/12A61P1/14A61K2300/00
Inventor 陈东松陈伟珊陈培麟
Owner GUANGDONG LITAI PHARM CO LTD
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