50 results about "Dyspepsias" patented technology

The invention relates to a traditional Chinese medicine composition for treating functional dyspepsia combined with anxiety and depression and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 200-781 parts of rhizoma pinellinae praeparata, 50-365 parts of coptis chinensis, 100-521 parts of scutellaria baicalensis, 150-625 parts of rhizoma zingiberis, 50-313 parts of ginseng, 100-417 parts of liquorice, 150-625 parts of Chinese dates and 150-521 parts of immature bitter orange. The traditional Chinese medicine composition has a good effect of treating functional dyspepsia combined with anxiety and depression, and the preparation method of the traditional Chinese medicine composition is simple and suitable for large-scale production and popularization.

The invention relates to the technical field of medicines, and discloses an application of a traditional Chinese medicine composition in a humanized flora transplantation model.The application comprises the following steps that an experimental body is pretreated through sterile feeding or broad-spectrum antibiotics, then coprophilous fungus suspension of a functional dyspepsia patient is transplanted, and the humanized flora transplantation model is constructed; acquiring physiological data of the humanized flora transplantation model, and performing intervention on the traditional Chinese medicine composition after the humanized flora transplantation model is completed; acquiring physiological data of the traditional Chinese medicine composition intervened humanized flora transplantation model, and analyzing an evaluation result of the traditional Chinese medicine composition intervened humanized flora transplantation model by combining the evaluation parameters of the humanized flora transplantation model. The bottleneck that the traditional animal model is greatly different from the human microflora and the curative effect and the mechanism are difficult to transform is overcome, so that the research result is closer to the clinical practice, and the molecular mechanism of the traditional Chinese medicine composition is reliably revealed.

The invention discloses a multi-layer multi-release metagen composition and application thereof in quickly promoting defecation, lubricating intestinal tracts, relieving intestinal problems such as flatulence, stomachache, diarrhea, constipation, irritable bowel syndrome and inflammatory bowel disease, maintaining intestinal flora balance, repairing intestinal tracts, repairing intestinal mucosa health, relieving dyspepsia and improving gastrointestinal functions.

This invention relates to a traditional Chinese medicine preparation for treating functional dyspepsia and its preparation method. The traditional Chinese medicine preparation is made from the following raw materials in parts by weight: Pinellia ternata 200-781 parts, Coptis chinensis 50-365 parts, Scutellaria baicalensis 100-521 parts, Zingiber officinale 150-625 parts, Panax ginseng 50-313 parts, Glycyrrhiza uralensis 100-417 parts, Ziziphus jujuba 150-625 parts, and Citrus aurantium 150-521 parts. The traditional Chinese medicine preparation of this invention has a good therapeutic effect on functional dyspepsia, and the preparation method of this traditional Chinese medicine preparation is simple and suitable for large-scale production and promotion.

The invention provides a traditional Chinese medicine composition formula for improving intestinal flora and application thereof, and relates to the technical field of traditional Chinese medicine, and the traditional Chinese medicine composition formula is prepared from the following raw materials: bighead atractylodes rhizome, poria cocos, pericarpium citri reticulatae, fructus amomi, fried malt, fried rice sprout, lotus seed, gordon euryale seed, dandelion, agastache rugosus, eupatorium, fried white hyacinth bean, medicated leaven, semen raphani and astragalus membranaceus. According to the invention, the number of beneficial bacteria in intestinal tracts can be increased, multi-target regulation of intestinal flora can be carried out, growth of harmful bacteria can be inhibited, diversity of intestinal flora can be improved, structural balance of flora can be recovered, the effect is comprehensive, and the effect is remarkable; the used raw materials are all medicinal and edible or common traditional Chinese medicines, are high in safety and have no obvious toxic or side effects; the traditional Chinese medicine composition is suitable for different types of intestinal flora disorder patients, and especially has a good treatment effect on functional dyspepsia, inflammatory diseases, irritable bowel syndrome and other diseases.

The application provides a pharmaceutical composition for functional dyspepsia and a preparation method and application thereof, and belongs to the technical field of medicines, and the pharmaceutical composition comprises the following components: Aucklandia, Atractylodes, Mentha, Agastache, Citrus aurantium, Uncaria, Tribulus terrestris, Guangdong Shenqu, Chrysanthemum, Poria cocos, Radix Trichosanthis, Coix seed, Magnolol, Imperatorin, Isoimperatorin, Oxypeucedanin, Ferulic acid, Vanillic acid, p-Coumaric acid and Puerarin. The pharmaceutical composition comprises traditional Chinese medicine components and compounds, the components interact with each other, the effect of the pharmaceutical composition on improving functional dyspepsia can be improved, and meanwhile, the pharmaceutical composition has excellent stability.

The application provides application of a Baoji oral liquid composition in preparation of a functional dyspepsia medicine, and relates to the technical field of medicines. The application is based on the Baoji oral liquid, and it is found that the Baoji oral liquid has a remarkable effect on treating functional dyspepsia, especially cisplatin-induced functional dyspepsia. Specifically, the Baoji oral liquid can rapidly restore body weight, significantly improve body weight gain, steadily promote food intake, significantly improve gastric emptying rate and intestinal propulsion rate, protect the gastric mucosa layer, reduce inflammatory cell infiltration, repair the mucosa layer and muscle layer, improve the expression of serum gastrin and motilin, and improve the expression level of IL-4 in the gastric tissue and reduce the expression level of IL-1beta. The Baoji oral liquid has remarkable efficacy when applied in preparation of a functional dyspepsia medicine.

The present application belongs to the field of biopharmacy, and particularly relates to a phenolic acid composition and application thereof in promoting digestion. The present application firstly finds a single phenolic acid for improving dyspepsia through single-component phenolic acid experiments, then attempts to find a phenolic acid compound with a synergistic effect through compounding, and surprisingly, the combination of two phenolic acids with the best effect on promoting digestion cannot achieve the best effect optimization, but eugenol with the worst effect on promoting digestion achieves a synergistic effect on promoting digestion through compounding with other phenolic acids, and can achieve the effect of a positive drug, which provides a potential alternative drug for improving dyspepsia.

The invention relates to the technical field of medicines, and discloses an application of a traditional Chinese medicine composition in serum neurotransmitter, which comprises the following steps: selecting 6-8 weeks old mice to establish a normal model, a chronic fatigue syndrome model and a functional dyspepsia model; the method comprises the following steps: sampling blood from mice of a normal model, a chronic fatigue syndrome model and a functional dyspepsia model to respectively obtain a normal blood sample, a CFS blood sample and an FD blood sample, and performing protein precipitation operation to obtain normal deproteinized supernatant, CFS deproteinized supernatant and FD deproteinized supernatant; separating by using a reversed-phase chromatographic column, and then carrying out mass spectrometric detection to respectively obtain a normal serum neurotransmitter mass spectrogram, a CFS serum neurotransmitter mass spectrogram and an FD serum neurotransmitter mass spectrogram; and carrying out concentration value calculation and rhythm fluctuation analysis to respectively obtain a neurotransmitter function index and a rhythm stability quantitative score. Therefore, the action mechanism of the serum neurotransmitter of the traditional Chinese medicine composition can be clearly and quantitatively represented.

The present application belongs to the technical field of traditional Chinese medicine, and specifically discloses a traditional Chinese medicine composition for treating children's functional dyspepsia, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw medicinal materials by weight: Fructus Aurantii Immaturus 5-20 parts, Magnolia officinalis 5-20 parts, Forsythia suspensa 5-30 parts, Dendrobium 5-30 parts, Atractylodes macrocephala 5-20 parts, and Glycyrrhiza 5-30 parts. The pharmacological experiment results show that the traditional Chinese medicine composition has the effects of improving gastrointestinal motility and regulating gastrointestinal hormone secretion, has a significant therapeutic effect on children's functional dyspepsia, has stable curative effect, and has a small dosage. Meanwhile, the present application has the advantages of simple process operation, low cost, good controllability and stability, and is suitable for industrialized mass production.

The invention relates to oral probiotic hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing inulin-modified thiolated polysaccharide with a probiotic liquid, and quickly crosslinking to form probiotic hydrogel, so as to construct a colon-targeted probiotic delivery system; the system can effectively protect the probiotics from passing through the upper digestive tract, and realizes targeted release of the probiotics at the colon part by using a dual mechanism that the inulin is specifically ingested by the probiotics in the colon and the disulfide bond is easily reduced and disassembled by reduced glutathione (GSH) in the colon. The oral probiotic hydrogel disclosed by the invention is applied to preparation of medicines for preventing and treating irritable bowel syndrome, diarrhea, constipation, dyspepsia, inflammatory bowel disease, colon cancer, diabetes mellitus, obesity and hypercholesteremia.

The application relates to the technical field of medicines, and discloses application of a traditional Chinese medicine composition in serum neurotransmitters, which comprises the following steps: selecting 6-8-week-old mice to establish normal models, chronic fatigue syndrome models and functional dyspepsia models; blood sampling is conducted on the mice of the normal models, the chronic fatigue syndrome models and the functional dyspepsia models to obtain normal blood samples, CFS blood samples and FD blood samples respectively; protein precipitation operation is conducted to obtain normal deproteinized supernatants, CFS deproteinized supernatants and FD deproteinized supernatants; separation is conducted by using a reversed-phase chromatographic column, and then mass spectrometry is conducted to obtain normal serum neurotransmitter mass spectra, CFS serum neurotransmitter mass spectra and FD serum neurotransmitter mass spectra respectively; concentration value calculation and rhythm fluctuation analysis are conducted to obtain a neurotransmitter function index and rhythm stability quantitative score respectively. Therefore, the mechanism of the traditional Chinese medicine composition in serum neurotransmitters is clearly quantitatively characterized.

Contemplated test kits and methods for food sensitivity are based on rational-based selection of food preparations with established discriminatory p-value. Particularly preferred kits include those with a minimum number of food preparations that have an average discriminatory p-value of ≤0.07 as determined by their raw p-value or an average discriminatory p-value of ≤0.10 as determined by FDR multiplicity adjusted p-value. In further contemplated aspects, compositions and methods for food sensitivity are also stratified by gender to further enhance predictive value.

The invention discloses a medicinal moxa composition for preventing and treating migraine and dyspepsia stomachache. The medicinal moxa composition comprises gypsum, ginseng, radix angelicae and moxa. Based on the theory that the stomach is mainly accepted and the spleen is mainly transported and transformed, the medicinal moxa composition disclosed by the invention starts from the stomach channel of foot yangming, has the effects of clearing heat, nourishing yin, invigorating the spleen, replenishing qi, regulating qi, relieving pain and the like, and can be used for improving the symptoms of migraine and dyspepsia abdominal pain at the same time. Gypsum has the effects of clearing heat and purging fire, ginseng has the effects of tonifying qi and spleen, radix angelicae has the effects of dispelling wind and relieving pain, moxa has the effects of warming channels and expelling cold and promoting blood circulation to remove meridian obstruction, and the four medicines are compatible to form a balanced system for clearing heat and nourishing yin, invigorating spleen and replenishing qi and regulating qi to relieve pain. The medicinal folium artemisiae argyi composition disclosed by the invention can be used for remarkably reducing the vasospasm degree of a migraine patient and improving the gastrointestinal motility function of a patient suffering from dyspepsia abdominal pain at the same time.

The present invention relates to Lacticaseibacillus paracasei HP7 with preventive or alleviative efficacy for functional dyspepsia and uses thereof. The composition comprising the Lacticaseibacillus paracasei HP7 strain (accession number: KCTC 13143 BP) of the present invention as an active ingredient was confirmed to increase expression of intestinal tight junction genes, improve gastrointestinal peristalsis and gastric emptying effects, enhances gastric weight and gastric emptying levels associated with gastric emptying, and significantly increase blood hormone levels related to digestive activity, thereby improving dyspepsia.

The invention belongs to the technical field of traditional Chinese medicine, and relates to application of Wanshi insecticidal and food retention-removing pills in medicine preparation. The change of a model mouse before and after administration is researched to prove that the Wanshi insecticidal and food retention removing pill can remarkably improve functional dyspepsia, reduce triglyceride and low-density lipoprotein in a body and reduce the level of proinflammatory factors in the body; the safety evaluation of repeated administration proves that no obvious toxic reaction occurs after long-term use of the Wanshi insecticidal and food retention-removing pill. The invention provides a new application of the Wanshi insecticidal and food retention removing pill, is applied to preparation of medicines for treating functional dyspepsia, reducing triglyceride and low-density lipoprotein and / or resisting inflammation, and has important clinical value.

The invention belongs to the technical field of special diet food, and discloses muscle-building and qi-tonifying protein powder and a preparation method thereof, the muscle-building and qi-tonifying protein powder comprises the following components by weight: 75%-80% of a compound protein matrix, 10%-12% of a slow-release carbon-water system, 8%-10% of a medicinal and edible spleen-tonifying composition and 0.5%-2% of a function enhancer; wherein the slow-release carbon water system is composed of low-GI maltodextrin and oat powder, the medicinal and edible spleen-tonifying formula is composed of an astragalus extract, a Chinese yam extract and a white hyacinth bean extract, the compound protein matrix is composed of whey protein, casein and soybean protein isolate, and the function enhancer is composed of BCAA peptide and glutamine. According to the protein powder disclosed by the invention, through a'protein-carbohydrate-spleen-tonifying extract 'ternary synergistic mechanism, while the muscle protein synthesis rate is increased, the incidence rate of spleen deficiency type dyspepsia is remarkably reduced, and the incidence rate of upper respiratory tract infection is reduced.

The present application belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine composition for treating fullness and application thereof. The traditional Chinese medicine composition comprises Chaihu, Baishao, Xinyinhua, Yujin, Taizishen, Wuzhimaotao, Fushen, Hehuanpi, Huazao, Jiguangxiang, Tanshang, Bamiaozha, Sharen, Baodoukou, Zixugeng, Lugen, Zhuzu, Dujiaojin, Chao'anyu, Busheye and Danshen. The traditional Chinese medicine composition has the effects of relieving depression and soothing the nerves, invigorating the spleen and tonifying qi, eliminating fullness and relieving distension, and follows the principles of 'treating the same disease with the same method' and 'treating the disease from the root'. The traditional Chinese medicine composition is in accordance with the principle of combination of monarch, minister, assistant and guide, has unique effects on chronic gastritis, functional dyspepsia and gastrointestinal neurosis of the type of liver depression and spleen deficiency, has no adverse reactions, is safe and effective, and is suitable for popularization and application.

The invention discloses application of compound radix astragali spleen-tonifying oral liquid to improvement of functional dyspepsia of young rats, and belongs to the technical field of medicines. Comprising the following steps: model construction and grouping: establishing a young rat functional dyspepsia model, randomly dividing successfully molded animals into a model control group, a positive drug control group and at least one compound radix astragali spleen-tonifying oral liquid administration group, and setting a blank control group; dosing in groups; performing pharmacodynamic evaluation; and analyzing data. The invention systematically discloses a multi-target action mechanism of the compound radix astragali spleen-tonifying oral liquid for treating functional dyspepsia for the first time, and provides an experimental basis for clinical popularization and application of the compound radix astragali spleen-tonifying oral liquid. The compound radix astragali spleen-tonifying oral liquid has the advantages of definite curative effect, comprehensive action mechanism, small adverse reaction and the like, and is particularly suitable for treating young functional dyspepsia patients.

The invention belongs to the technical field of medicines, and particularly relates to oral liquid for promoting digestion, relieving indigestion and supplementing calcium, iron and zinc and a preparation method thereof. Comprising the following steps: extracting and purifying rorippa formosana polysaccharide; preparing an auxiliary digestion promoting agent; preparing an aromatic digestion promoting agent; and compounding the oral liquid. The preparation method comprises the following steps: extracting rorippa formosana crude polysaccharide from rorippa formosana through water extraction and alcohol precipitation, then carrying out chromatography on the rorippa formosana crude polysaccharide by using a DEAE cellulose DE-52 column to prepare rorippa formosana polysaccharide, acetylating the rorippa formosana polysaccharide, and compounding with a mixed concentrated solution obtained by water extraction and concentration of hawthorn, coix seed and Chinese yam to obtain the rorippa formosana polysaccharide compound. The prepared auxiliary digestion promoting agent is applied to the oral liquid, so that the effects of promoting digestion and relieving stasis can be enhanced, and the absorption and utilization of the body on effective components of food can be promoted, thereby effectively improving and treating the dyspepsia problem of the human body, improving the appetite of children, and avoiding the phenomena of malnutrition and immunity decline caused by dyspepsia and poor appetite.

This invention discloses a traditional Chinese medicine composition for treating functional dyspepsia in combination with massage, its preparation method, and its application. The composition mainly comprises the following raw materials in parts by weight: 5-15 parts black sesame seeds, 2-8 parts almonds, 2-8 parts wild papaya, 2-8 parts *Drynaria fortunei*, and 2-8 parts peony bark. Compared to existing technologies, this invention provides a novel and simple traditional Chinese medicine composition for treating functional dyspepsia, and its preparation method is simple and low-cost. This composition is specifically designed for use in combination with massage to treat functional dyspepsia, and is especially suitable for children who dislike taking medicine. Applying it around the navel and massaging appropriately can effectively treat functional dyspepsia. Animal experiments have confirmed that the traditional Chinese medicine composition of this invention, used in combination with massage, has a significant effect on treating functional dyspepsia.

Systems and methods are provided for providing improved information, diagnoses and therapies for dyspepsia and gastric emptying disorders based on gastric protein emptying and gastric carbohydrate emptying data.

The invention discloses a traditional Chinese medicine composition for treating functional dyspepsia with brain-intestine peptide disorder. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 20-40 parts of codonopsis pilosula, 10-20 parts of poria cocos, 10-20 parts of Chinese yam, 5-15 parts of fingered citron, 10-15 parts of hawthorn and 2-8 parts of liquorice. Animal experiments prove that the traditional Chinese medicine composition disclosed by the invention has a remarkable effect in the aspect of treating functional dyspepsia with brain-intestine peptide disorder.

The invention discloses a preparation process of a Chinese patent medicine for treating gastric motility disorder type functional dyspepsia. According to the method, twelve medicinal materials including radix bupleuri, fructus aurantii immaturus, radix aucklandiae, pericarpium citri reticulatae, rhizoma pinelliae preparata, herba taraxaci, fructus crataegi (fried to be scorched), scorched areca-nut, paederia scandens, radix codonopsis, rhizoma corydalis and medicated leaven (fried) are subjected to a series of operation such as decoction, oil extraction, alcohol precipitation, concentration and inclusion to obtain extract, and the extract is used as a raw material; the preparation method comprises the following steps: mixing raw materials or raw materials and auxiliary materials, spraying the mixture on the surfaces of the auxiliary materials and the sweetening agent at a certain speed through an atomizing spray gun, continuously mixing the auxiliary materials and the sweetening agent in a boiling dryer, spraying an adhesive, condensing, granulating, drying and the like, and completing the granulation process at one time. Mixing, drying and pelletizing can be completed through one device, the device has the advantages of being easy to operate and low in labor intensity, the prepared particles are uniform in particle size and good in flowability and compressibility, and the production efficiency and the product quality can be improved.

The invention discloses a medicinal moxa composition for preventing and treating rectocele and dyspepsia. The medicinal moxa composition comprises radix bupleuri, fructus aurantii, pericarpium citri reticulatae viride and moxa. The medicinal moxa composition disclosed by the invention directly acts on body surface acupuncture points through a synergistic effect of volatile components released by combustion and heating power, and particularly aims at related acupuncture points of hand-Shaoyang meridians, so that multi-target treatment of a co-disease of rectocele and dyspepsia is realized. According to the treatment principle of soothing liver and regulating qi and lifting up yang and yang, the traditional Chinese medicine composition is externally used for regulating qi movement, improving liver and gall dredging functions and promoting transportation and transformation of spleen and stomach, so that the treatment purpose is achieved. Volatile components in the medicinal folium artemisiae argyi composition have remarkable antibacterial, anti-inflammatory, anti-oxidation and intestinal flora regulating effects, can synergistically act on multiple key targets related to rectocele and dyspepsia, participate in regulation and control of multiple pathways, and provide a scientific basis for co-disease treatment.

The present application relates to the field of medicine synthesis, disclose a long-acting dual agonist compound. The tirzepatide derivative described in the application is used for preparing a pharmaceutical composition for treating diseases, the use of the pharmaceutical composition in the preparation of a medicine for treating at least one of the following diseases, the diseases include type II diabetes, impaired glucose tolerance, type I diabetes, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, stroke, inflammatory bowel syndrome and / or indigestion or gastric ulcer, liver fibrosis disease and pulmonary fibrosis disease.

A digestion-aiding olive fruit solid beverage belongs to the field of olive fruit beverages, and comprises 70-80 parts of olive fruit instant powder, 3-5 parts of probiotic powder, 6-8 parts of composite small molecule peptide powder, 0.3-0.5 part of a sour agent, and 0.2-0.3 part of a sweetening agent. The instant olive fruit powder is rich in polyphenols, vitamins and minerals, and is beneficial to promoting gastrointestinal motility and enhancing the digestive function; according to the probiotic powder disclosed by the invention, lactobacillus acidophilus powder, lactobacillus casei powder and lactobacillus plantarum powder are selected to be compounded for use, and the three components have a synergistic effect, so that gastrointestinal functions can be effectively regulated, digestion is promoted, and gastrointestinal health is promoted; through the synergistic effect of various substances, the traditional Chinese medicine composition can effectively regulate gastrointestinal functions, promote digestion, promote gastrointestinal health and avoid dyspepsia; the health-care tea adopts natural plant extracts, does not contain chemical additives, is high in safety, and is suitable for long-term drinking to prevent and improve gastrointestinal problems such as dyspepsia.

The present application belongs to the technical field of medicine, and especially relates to a kind of appetizing and digesting tablets. The problem caused by dyspepsia is solved to solve dyspepsia. The technical scheme is as follows: the main use is to relieve dyspepsia.

The application discloses a kind of FD auxiliary evaluation information processing methods based on gastrointestinal electrical signal, it is related to medical auxiliary diagnosis technical field, it is applied to the functional dyspepsia auxiliary diagnosis scene of obese crowd, including obtaining the individualized medical record data of target object, the individualized medical record data includes at least two in body shape parameter, weight loss surgery history and metabolic drug history;Three evaluation paths of parallel operation are constructed.The present application solves the core technical problems of EGG signal systematic distortion and main frequency detection distortion caused by abdominal fat layer of obese crowd, breaks through the long-term technical prejudice of existing EGG diagnostic equipment to exclude obese patients, realizes reliable auxiliary evaluation information under the condition that patients cannot maintain standard signal quality, eliminates the systematic misjudgment of fat layer to EGG diagnosis, so that the signal entering subsequent analysis link can truly reflect the gastric electrical physiological state of target object.