74 results about "Dyspepsias" patented technology

The invention relates to the field of medicine synthesis, and discloses a GLP-1 / GIP / GCG tri-agonist compound. The GLP-1 / GIP / GCG three-agonist compound is used for preparing a medicine composition for treating diseases, and the application of the medicine composition in preparing a medicine for treating at least one of the following diseases, namely, the GLP-1 / GIP / GCG three-agonist compound, and the GLP-1 / GIP / GCG three-agonist compound. The diseases include type II diabetes mellitus, impaired glucose tolerance, type I diabetes mellitus, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, stroke, inflammatory bowel syndrome and / or dyspepsia or gastric ulcer, hepatic fibrosis disease and pulmonary fibrosis disease.

The invention relates to the field of medicine synthesis, and discloses a GLP-1 / GIP / GCG tri-agonist compound. The GLP-1 / GIP / GCG three-agonist compound is used for preparing a medicine composition for treating diseases, and the application of the medicine composition in preparing a medicine for treating at least one of the following diseases, namely, the GLP-1 / GIP / GCG three-agonist compound, and the GLP-1 / GIP / GCG three-agonist compound. The diseases include type II diabetes mellitus, impaired glucose tolerance, type I diabetes mellitus, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, stroke, inflammatory bowel syndrome and / or dyspepsia or gastric ulcer, hepatic fibrosis disease and pulmonary fibrosis disease.

The invention relates to a traditional Chinese medicine composition for treating functional dyspepsia combined with anxiety and depression and a preparation method thereof. The traditional Chinese medicine composition is prepared from the following traditional Chinese medicine raw materials in parts by weight: 200-781 parts of rhizoma pinellinae praeparata, 50-365 parts of coptis chinensis, 100-521 parts of scutellaria baicalensis, 150-625 parts of rhizoma zingiberis, 50-313 parts of ginseng, 100-417 parts of liquorice, 150-625 parts of Chinese dates and 150-521 parts of immature bitter orange. The traditional Chinese medicine composition has a good effect of treating functional dyspepsia combined with anxiety and depression, and the preparation method of the traditional Chinese medicine composition is simple and suitable for large-scale production and popularization.

The invention relates to the technical field of medicines, and discloses an application of a traditional Chinese medicine composition in a humanized flora transplantation model.The application comprises the following steps that an experimental body is pretreated through sterile feeding or broad-spectrum antibiotics, then coprophilous fungus suspension of a functional dyspepsia patient is transplanted, and the humanized flora transplantation model is constructed; acquiring physiological data of the humanized flora transplantation model, and performing intervention on the traditional Chinese medicine composition after the humanized flora transplantation model is completed; acquiring physiological data of the traditional Chinese medicine composition intervened humanized flora transplantation model, and analyzing an evaluation result of the traditional Chinese medicine composition intervened humanized flora transplantation model by combining the evaluation parameters of the humanized flora transplantation model. The bottleneck that the traditional animal model is greatly different from the human microflora and the curative effect and the mechanism are difficult to transform is overcome, so that the research result is closer to the clinical practice, and the molecular mechanism of the traditional Chinese medicine composition is reliably revealed.

The invention discloses a multi-layer multi-release metagen composition and application thereof in quickly promoting defecation, lubricating intestinal tracts, relieving intestinal problems such as flatulence, stomachache, diarrhea, constipation, irritable bowel syndrome and inflammatory bowel disease, maintaining intestinal flora balance, repairing intestinal tracts, repairing intestinal mucosa health, relieving dyspepsia and improving gastrointestinal functions.

The invention belongs to the field of biological pharmacy, and particularly relates to a phenolic acid composition and application thereof in promoting digestion. According to the invention, monophenolic acid for improving dyspepsia is found through a single-component phenolic acid experiment, and then a phenolic acid compound with a synergistic effect is searched in a compounding manner, so that unexpectedly, the combination of two phenolic acids with the best digestion promoting effect cannot realize the effect optimization; on the contrary, syringic acid with the worst digestion promoting effect is compounded with other phenolic acids, so that the synergistic digestion promoting effect is achieved, the effect of a positive medicine can be achieved, and a potential optional medicine is provided for improving dyspepsia.

The invention belongs to the technical field of traditional Chinese medicine preparations, and provides a traditional Chinese medicine granule composition based on rhizoma polygonati and a preparation method and application thereof. A three-layer intelligent response structure design is adopted, a 80-300 nm rhizoma polygonati nano core is prepared through an anti-solvent precipitation technology, a calcium alginate gel buffer layer containing probiotic nutritional factors is constructed through an ionic crosslinking technology, a pH response shell layer is prepared through a fluidized bed coating technology, and the release rate lt in gastric juice is achieved; the cumulative release rate gt in intestinal juice is 10%; according to the invention, the rhizoma polygonati polysaccharide and probiotic nutritional factors are added into the preparation, the precise intestinal targeted release performance is 80%, the drug loading capacity is 15-35%, the coating efficiency is 85-95%, and the technical problems that a traditional rhizoma polygonati preparation is poor in stability, effective components are damaged by gastric acid, and the bioavailability is low are solved; the traditional Chinese medicine composition can be used for treating diseases such as weakness of the spleen and the stomach, functional dyspepsia and dysbacteriosis of intestinal flora, and has wide application value.

This invention relates to a traditional Chinese medicine preparation for treating functional dyspepsia and its preparation method. The traditional Chinese medicine preparation is made from the following raw materials in parts by weight: Pinellia ternata 200-781 parts, Coptis chinensis 50-365 parts, Scutellaria baicalensis 100-521 parts, Zingiber officinale 150-625 parts, Panax ginseng 50-313 parts, Glycyrrhiza uralensis 100-417 parts, Ziziphus jujuba 150-625 parts, and Citrus aurantium 150-521 parts. The traditional Chinese medicine preparation of this invention has a good therapeutic effect on functional dyspepsia, and the preparation method of this traditional Chinese medicine preparation is simple and suitable for large-scale production and promotion.

The present invention relates to the field of pharmaceutical synthesis. A GLP-1 / Gcg dual-agonist compound is disclosed. The GLP-1 / Gcg dual-agonist compound is used for preparing a pharmaceutical composition for treating disease. Use of the pharmaceutical composition in the preparation of a drug for treating at least one of the following diseases: type-II diabetes, impaired glucose tolerance, type-I diabetes, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive disorders, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, strokes, inflammatory bowel syndrome and / or dyspepsia or gastric ulcers, hepatic fibrosis disease, and pulmonary fibrosis disease.

The invention provides a traditional Chinese medicine composition formula for improving intestinal flora and application thereof, and relates to the technical field of traditional Chinese medicine, and the traditional Chinese medicine composition formula is prepared from the following raw materials: bighead atractylodes rhizome, poria cocos, pericarpium citri reticulatae, fructus amomi, fried malt, fried rice sprout, lotus seed, gordon euryale seed, dandelion, agastache rugosus, eupatorium, fried white hyacinth bean, medicated leaven, semen raphani and astragalus membranaceus. According to the invention, the number of beneficial bacteria in intestinal tracts can be increased, multi-target regulation of intestinal flora can be carried out, growth of harmful bacteria can be inhibited, diversity of intestinal flora can be improved, structural balance of flora can be recovered, the effect is comprehensive, and the effect is remarkable; the used raw materials are all medicinal and edible or common traditional Chinese medicines, are high in safety and have no obvious toxic or side effects; the traditional Chinese medicine composition is suitable for different types of intestinal flora disorder patients, and especially has a good treatment effect on functional dyspepsia, inflammatory diseases, irritable bowel syndrome and other diseases.

The application provides a pharmaceutical composition for functional dyspepsia and a preparation method and application thereof, and belongs to the technical field of medicines, and the pharmaceutical composition comprises the following components: Aucklandia, Atractylodes, Mentha, Agastache, Citrus aurantium, Uncaria, Tribulus terrestris, Guangdong Shenqu, Chrysanthemum, Poria cocos, Radix Trichosanthis, Coix seed, Magnolol, Imperatorin, Isoimperatorin, Oxypeucedanin, Ferulic acid, Vanillic acid, p-Coumaric acid and Puerarin. The pharmaceutical composition comprises traditional Chinese medicine components and compounds, the components interact with each other, the effect of the pharmaceutical composition on improving functional dyspepsia can be improved, and meanwhile, the pharmaceutical composition has excellent stability.

The application provides application of a Baoji oral liquid composition in preparation of a functional dyspepsia medicine, and relates to the technical field of medicines. The application is based on the Baoji oral liquid, and it is found that the Baoji oral liquid has a remarkable effect on treating functional dyspepsia, especially cisplatin-induced functional dyspepsia. Specifically, the Baoji oral liquid can rapidly restore body weight, significantly improve body weight gain, steadily promote food intake, significantly improve gastric emptying rate and intestinal propulsion rate, protect the gastric mucosa layer, reduce inflammatory cell infiltration, repair the mucosa layer and muscle layer, improve the expression of serum gastrin and motilin, and improve the expression level of IL-4 in the gastric tissue and reduce the expression level of IL-1beta. The Baoji oral liquid has remarkable efficacy when applied in preparation of a functional dyspepsia medicine.

The present application belongs to the field of biopharmacy, and particularly relates to a phenolic acid composition and application thereof in promoting digestion. The present application firstly finds a single phenolic acid for improving dyspepsia through single-component phenolic acid experiments, then attempts to find a phenolic acid compound with a synergistic effect through compounding, and surprisingly, the combination of two phenolic acids with the best effect on promoting digestion cannot achieve the best effect optimization, but eugenol with the worst effect on promoting digestion achieves a synergistic effect on promoting digestion through compounding with other phenolic acids, and can achieve the effect of a positive drug, which provides a potential alternative drug for improving dyspepsia.

The invention relates to the technical field of medicines, and discloses an application of a traditional Chinese medicine composition in serum neurotransmitter, which comprises the following steps: selecting 6-8 weeks old mice to establish a normal model, a chronic fatigue syndrome model and a functional dyspepsia model; the method comprises the following steps: sampling blood from mice of a normal model, a chronic fatigue syndrome model and a functional dyspepsia model to respectively obtain a normal blood sample, a CFS blood sample and an FD blood sample, and performing protein precipitation operation to obtain normal deproteinized supernatant, CFS deproteinized supernatant and FD deproteinized supernatant; separating by using a reversed-phase chromatographic column, and then carrying out mass spectrometric detection to respectively obtain a normal serum neurotransmitter mass spectrogram, a CFS serum neurotransmitter mass spectrogram and an FD serum neurotransmitter mass spectrogram; and carrying out concentration value calculation and rhythm fluctuation analysis to respectively obtain a neurotransmitter function index and a rhythm stability quantitative score. Therefore, the action mechanism of the serum neurotransmitter of the traditional Chinese medicine composition can be clearly and quantitatively represented.

Provided herein is a bulk composition comprising the trihydrate form of (3S, 4R, 3′R)-6-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-azabicyclo[2.2.2]oct-3′-yl ester di-hydrochloride salt. Provided are also pharmaceutical compositions and dosage forms comprising the trihydrate form, and methods and uses for treating a gastrointestinal disorder in a subject with the trihydrate form. In some embodiments, the gastrointestinal disorder is gastroesophageal reflux disease (GERD), dyspepsia (such as functional dyspepsia or functional motility disorder), gastroparesis, paralytic ileus, post-operative ileus, emesis, nausea, heartburn, intestinal pseudo-obstruction, irritable bowel syndrome (IBS), constipation, enteral feeding intolerance (EFI), or esophagitis. In some embodiments, the gastrointestinal disorder is post-operative ileus, chronic grass sickness, constipation, megacolon, gastritis, gastrointestinal stasis, or abomasal emptying defect.

The present application belongs to the technical field of traditional Chinese medicine, and specifically discloses a traditional Chinese medicine composition for treating children's functional dyspepsia, a preparation method and application thereof. The traditional Chinese medicine composition is prepared from the following raw medicinal materials by weight: Fructus Aurantii Immaturus 5-20 parts, Magnolia officinalis 5-20 parts, Forsythia suspensa 5-30 parts, Dendrobium 5-30 parts, Atractylodes macrocephala 5-20 parts, and Glycyrrhiza 5-30 parts. The pharmacological experiment results show that the traditional Chinese medicine composition has the effects of improving gastrointestinal motility and regulating gastrointestinal hormone secretion, has a significant therapeutic effect on children's functional dyspepsia, has stable curative effect, and has a small dosage. Meanwhile, the present application has the advantages of simple process operation, low cost, good controllability and stability, and is suitable for industrialized mass production.

The invention relates to oral probiotic hydrogel as well as a preparation method and application thereof. The preparation method comprises the following steps: mixing inulin-modified thiolated polysaccharide with a probiotic liquid, and quickly crosslinking to form probiotic hydrogel, so as to construct a colon-targeted probiotic delivery system; the system can effectively protect the probiotics from passing through the upper digestive tract, and realizes targeted release of the probiotics at the colon part by using a dual mechanism that the inulin is specifically ingested by the probiotics in the colon and the disulfide bond is easily reduced and disassembled by reduced glutathione (GSH) in the colon. The oral probiotic hydrogel disclosed by the invention is applied to preparation of medicines for preventing and treating irritable bowel syndrome, diarrhea, constipation, dyspepsia, inflammatory bowel disease, colon cancer, diabetes mellitus, obesity and hypercholesteremia.

The invention provides a medicine composition for invigorating stomach and dispelling cold as well as a preparation and application thereof, and the medicine composition is prepared from the following raw materials in parts by weight: 20-30 parts of gypsum rubrum, 10-15 parts of fructus amomi rotundus, 10-15 parts of fructus piperis longi powder, 10-15 parts of pomegranate seeds, 10-15 parts of flos carthami, 10-15 parts of radix aucklandiae, 10-15 parts of coriander, 10-15 parts of radix inulae inula and 10-15 parts of pawpaw, the preparation method of the fructus piperis longi powder comprises the following steps: crushing fructus piperis longi, pre-soaking, adding mesoporous silica nanoparticles, adding an ethanol aqueous solution, adjusting the pH value, performing ultrasonic-assisted extraction, filtering, purifying, concentrating and drying to obtain the fructus piperis longi powder; amomum kravanh powder is extracted with the assistance of a deep eutectic solvent, and the content of effective components of the medicine is increased through the preparation method. The pharmaceutical composition disclosed by the invention is scientific in formula and capable of effectively treating sour regurgitation of stomach, gastric ulcer, dyspepsia and inappetence due to the synergistic effect of all the components, and has clinical medication value.

The application relates to the technical field of medicines, and discloses application of a traditional Chinese medicine composition in serum neurotransmitters, which comprises the following steps: selecting 6-8-week-old mice to establish normal models, chronic fatigue syndrome models and functional dyspepsia models; blood sampling is conducted on the mice of the normal models, the chronic fatigue syndrome models and the functional dyspepsia models to obtain normal blood samples, CFS blood samples and FD blood samples respectively; protein precipitation operation is conducted to obtain normal deproteinized supernatants, CFS deproteinized supernatants and FD deproteinized supernatants; separation is conducted by using a reversed-phase chromatographic column, and then mass spectrometry is conducted to obtain normal serum neurotransmitter mass spectra, CFS serum neurotransmitter mass spectra and FD serum neurotransmitter mass spectra respectively; concentration value calculation and rhythm fluctuation analysis are conducted to obtain a neurotransmitter function index and rhythm stability quantitative score respectively. Therefore, the mechanism of the traditional Chinese medicine composition in serum neurotransmitters is clearly quantitatively characterized.

The present invention relates to the field of pharmaceutical combination components and discloses a GLP-1 / Gcg dual agonist compound. The GLP-1 / Gcg dual agonist compound described above is used for manufacturing a pharmaceutical composition for treating diseases. The pharmaceutical composition is used for manufacturing a medicament for treating at least one of diseases including type 2 diabetes, impaired glucose tolerance, type 1 diabetes, obesity, hypertension, metabolic syndrome, dyslipidemia, cognitive impairment, atherosclerosis, myocardial infarction, coronary heart disease, cardiovascular disease, stroke, inflammatory bowel syndrome and / or indigestion or gastric ulcer, liver fibrosis and pulmonary fibrosis.

Contemplated test kits and methods for food sensitivity are based on rational-based selection of food preparations with established discriminatory p-value. Particularly preferred kits include those with a minimum number of food preparations that have an average discriminatory p-value of ≤0.07 as determined by their raw p-value or an average discriminatory p-value of ≤0.10 as determined by FDR multiplicity adjusted p-value. In further contemplated aspects, compositions and methods for food sensitivity are also stratified by gender to further enhance predictive value.

The invention relates to the technical field of traditional Chinese medicine, in particular to Jianqu and a processing method thereof, and the Jianqu comprises the following raw materials and auxiliary materials: polygonum hydropiper, eupatorium, artemisia apiacea, semen armeniacae amarae, phaseolus calcaratus, fructus aurantii (stir-fried with bran), betel nut powder, rhizoma cyperi powder, magnolia officinalis powder, mint powder, rice sprout powder, malt powder, cinnamon powder, perilla powder, hawthorn (stir-fried), rhizoma atractylodis, radix angelicae, pericarpium citri reticulatae, pogostemon cablin, liquorice, common vladimiria root, wheat bran and flour. According to the Jianqu disclosed by the invention, the herba eupatorii which also has the functions of relieving exterior syndrome and resolving dampness, can promote digestive juice secretion and does not contain toxicity is used for replacing xanthium sibiricum, and the formula does not contain the xanthium sibiricum with toxicity, so that the original effects of improving dyspepsia and relieving gastrointestinal discomfort can be well maintained and even improved; moreover, the injury to the liver can be well avoided, and the safety is better.

The invention discloses a medicinal moxa composition for preventing and treating migraine and dyspepsia stomachache. The medicinal moxa composition comprises gypsum, ginseng, radix angelicae and moxa. Based on the theory that the stomach is mainly accepted and the spleen is mainly transported and transformed, the medicinal moxa composition disclosed by the invention starts from the stomach channel of foot yangming, has the effects of clearing heat, nourishing yin, invigorating the spleen, replenishing qi, regulating qi, relieving pain and the like, and can be used for improving the symptoms of migraine and dyspepsia abdominal pain at the same time. Gypsum has the effects of clearing heat and purging fire, ginseng has the effects of tonifying qi and spleen, radix angelicae has the effects of dispelling wind and relieving pain, moxa has the effects of warming channels and expelling cold and promoting blood circulation to remove meridian obstruction, and the four medicines are compatible to form a balanced system for clearing heat and nourishing yin, invigorating spleen and replenishing qi and regulating qi to relieve pain. The medicinal folium artemisiae argyi composition disclosed by the invention can be used for remarkably reducing the vasospasm degree of a migraine patient and improving the gastrointestinal motility function of a patient suffering from dyspepsia abdominal pain at the same time.

The present invention relates to Lacticaseibacillus paracasei HP7 with preventive or alleviative efficacy for functional dyspepsia and uses thereof. The composition comprising the Lacticaseibacillus paracasei HP7 strain (accession number: KCTC 13143 BP) of the present invention as an active ingredient was confirmed to increase expression of intestinal tight junction genes, improve gastrointestinal peristalsis and gastric emptying effects, enhances gastric weight and gastric emptying levels associated with gastric emptying, and significantly increase blood hormone levels related to digestive activity, thereby improving dyspepsia.

The invention belongs to the technical field of traditional Chinese medicine, and relates to application of Wanshi insecticidal and food retention-removing pills in medicine preparation. The change of a model mouse before and after administration is researched to prove that the Wanshi insecticidal and food retention removing pill can remarkably improve functional dyspepsia, reduce triglyceride and low-density lipoprotein in a body and reduce the level of proinflammatory factors in the body; the safety evaluation of repeated administration proves that no obvious toxic reaction occurs after long-term use of the Wanshi insecticidal and food retention-removing pill. The invention provides a new application of the Wanshi insecticidal and food retention removing pill, is applied to preparation of medicines for treating functional dyspepsia, reducing triglyceride and low-density lipoprotein and / or resisting inflammation, and has important clinical value.

The invention belongs to the technical field of special diet food, and discloses muscle-building and qi-tonifying protein powder and a preparation method thereof, the muscle-building and qi-tonifying protein powder comprises the following components by weight: 75%-80% of a compound protein matrix, 10%-12% of a slow-release carbon-water system, 8%-10% of a medicinal and edible spleen-tonifying composition and 0.5%-2% of a function enhancer; wherein the slow-release carbon water system is composed of low-GI maltodextrin and oat powder, the medicinal and edible spleen-tonifying formula is composed of an astragalus extract, a Chinese yam extract and a white hyacinth bean extract, the compound protein matrix is composed of whey protein, casein and soybean protein isolate, and the function enhancer is composed of BCAA peptide and glutamine. According to the protein powder disclosed by the invention, through a'protein-carbohydrate-spleen-tonifying extract 'ternary synergistic mechanism, while the muscle protein synthesis rate is increased, the incidence rate of spleen deficiency type dyspepsia is remarkably reduced, and the incidence rate of upper respiratory tract infection is reduced.

Provided herein is a bulk composition comprising the trihydrate form of (3S, 4R, 3′R)-6-[4-(4-amino-5-chloro-2-methoxy-benzoylamino)-3-methoxy-piperidin-1-yl]-hexanoic acid 1-azabicyclo[2.2.2]oct-3′-yl ester di-hydrochloride salt. Provided are also pharmaceutical compositions and dosage forms comprising the trihydrate form, and methods and uses for treating a gastrointestinal disorder in a subject with the trihydrate form. In some embodiments, the gastrointestinal disorder is gastroesophageal reflux disease (GERD), dyspepsia (such as functional dyspepsia or functional motility disorder), gastroparesis, paralytic ileus, post-operative ileus, emesis, nausea, heartburn, intestinal pseudo-obstruction, irritable bowel syndrome (IBS), constipation, enteral feeding intolerance (EFI), or esophagitis. In some embodiments, the gastrointestinal disorder is post-operative ileus, chronic grass sickness, constipation, megacolon, gastritis, gastrointestinal stasis, or abomasal emptying defect.

The present application belongs to the technical field of traditional Chinese medicine preparation, and particularly relates to a traditional Chinese medicine composition for treating fullness and application thereof. The traditional Chinese medicine composition comprises Chaihu, Baishao, Xinyinhua, Yujin, Taizishen, Wuzhimaotao, Fushen, Hehuanpi, Huazao, Jiguangxiang, Tanshang, Bamiaozha, Sharen, Baodoukou, Zixugeng, Lugen, Zhuzu, Dujiaojin, Chao'anyu, Busheye and Danshen. The traditional Chinese medicine composition has the effects of relieving depression and soothing the nerves, invigorating the spleen and tonifying qi, eliminating fullness and relieving distension, and follows the principles of 'treating the same disease with the same method' and 'treating the disease from the root'. The traditional Chinese medicine composition is in accordance with the principle of combination of monarch, minister, assistant and guide, has unique effects on chronic gastritis, functional dyspepsia and gastrointestinal neurosis of the type of liver depression and spleen deficiency, has no adverse reactions, is safe and effective, and is suitable for popularization and application.

The invention discloses application of compound radix astragali spleen-tonifying oral liquid to improvement of functional dyspepsia of young rats, and belongs to the technical field of medicines. Comprising the following steps: model construction and grouping: establishing a young rat functional dyspepsia model, randomly dividing successfully molded animals into a model control group, a positive drug control group and at least one compound radix astragali spleen-tonifying oral liquid administration group, and setting a blank control group; dosing in groups; performing pharmacodynamic evaluation; and analyzing data. The invention systematically discloses a multi-target action mechanism of the compound radix astragali spleen-tonifying oral liquid for treating functional dyspepsia for the first time, and provides an experimental basis for clinical popularization and application of the compound radix astragali spleen-tonifying oral liquid. The compound radix astragali spleen-tonifying oral liquid has the advantages of definite curative effect, comprehensive action mechanism, small adverse reaction and the like, and is particularly suitable for treating young functional dyspepsia patients.

The invention discloses a preparation method and application of a traditional Chinese medicine composition for improving diarrhea, relates to the technical field of traditional Chinese medicine compositions, and solves the problem of poor clinical improvement effect of existing compatibility. The preparation method comprises the following steps: processing rhizoma zingiberis, rhizoma atractylodis macrocephalae, radix glycyrrhizae and fructus gardeniae, adding ginseng, weighing the processed rhizoma zingiberis, rhizoma atractylodis macrocephalae, radix glycyrrhizae and fructus gardeniae, uniformly mixing, crushing, decocting with water for multiple times, filtering with gauze, and merging filtrates to obtain the traditional Chinese medicine composition. The invention can be used for preparing the traditional Chinese medicine preparation for improving diarrhea. The dosage forms of the traditional Chinese medicine preparation comprise granules, oral thick paste, oral liquid, powder, pills, tablets and capsules. The traditional Chinese medicine composition can be applied to prevention and health care of acute and chronic diarrhea and functional dyspepsia, can be intermittently taken by people with long-term spleen deficiency and easy diarrhea at low dosage, and can also be used for combined medication. On the premise of maintaining cell safety, side effects of traditional hormone therapy are avoided through component synergy, and a new direction is provided for developing a novel anti-diarrhea preparation with both safety and high efficiency.