Methods for treating myeloproliferative neoplasm-associated myelofibrosis and anemia
A myelofibrosis and tumor-related technology, which is applied in the field of treatment of myelofibrosis and anemia related to myeloproliferative tumors, can solve the problems of short duration of response medium, shortened splenectomy survival time, and aggravated anemia.
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[0193] Myeloproliferative neoplasms (MPN)-associated myelofibrosis (MF) is a clonal myeloid neoplasm characterized by myelofibrosis, defective bone marrow function, extramedullary hematopoiesis, propensity to blastocyst transition, and inflammation (Mesa RA et al. LeukRes. 2011;35(1):12-13). Anemia and red blood cell (RBC) transfusion dependence (TD) are independent poor prognosis and survival predictors in these patients (Passamonti F et al. Blood. 2010; 115(9):1703-1708; Elena C et al. Haematologica. 2011 ; 96(1):167-170).
[0194] Raspartercept is a recombinant fusion protein consisting of a modified type IIB activin receptor linked to the Fc domain of human immunoglobulin G1 (IgG1) ( figure 1 ) (Attie KM et al. Am J Hematol. 2014; 89(7):766-770; Suragani RN et al. Nat Med. 2014; 20(4):408-414). Raspartercept acts as an erythroid maturation agent by binding to specific transforming growth factor-beta (TGF-beta) superfamily ligands, such as gro...
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