A kind of polypeptide and its application

A drug and pharmaceutical technology, applied in the field of peptides, can solve the problems of single pharmacological target, high toxicity of chemical drugs, low safety, etc., and achieve the effect of reducing expression content, improving lung tissue structure, and high safety.
CN110437311BActive Publication Date: 2022-05-20NANJING ANJI BIOLOGICAL TECH CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
NANJING ANJI BIOLOGICAL TECH CO LTD
Publication Date
2022-05-20

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Abstract

The invention discloses an application of a polypeptide and belongs to the field of biopharmaceuticals. 1. A polypeptide, characterized in that, the structural domain Pro-Arg-Cys-X-Y-Gly-Glu contained in the polypeptide, wherein X is Trp or Tyr; Y is Arg or Cys; and Arg-Gly-Ala- Asp-Arg-Ala; or the sequence after mutating any amino acid in the above domain; can treat various fibrotic diseases and conditions, including pulmonary fibrosis, liver fibrosis, bone marrow fibrosis, renal fibrosis and myocardial fibrosis , skin fibrosis and lung tissue lesions.
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Description

technical field

[0001] The invention belongs to the field of biopharmaceuticals, and more specifically relates to a polypeptide that can be used to prevent or treat various fibrotic diseases. And anti-myocardial fibrosis, anti-skin fibrosis. Background technique

[0002] Fibrosis is defined as the excessive deposition of extracellular matrix (ECM) components such as fibronectin (FN) and type I collagen (COLI) by organ fibroblasts. Organ fibrosis is the final common pathway of many diseases leading to end organ failure. Uncontrollable wound healing responses, including acute and chronic inflammation, angiogenesis, activation of fibroblasts, and remodeling of the extracellular matrix, are involved in the pathogenesis of fibrosis. At present, the pathogenesis, diagnosis methods and prevention and treatment measures of organ or tissue fibrosis have been extensively studied. In the existing technology, although considerable progress has been made in some aspects, there are stil...

Claims

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