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Application of compound cortex phellodendri liquid liniment in preparation of medicine for treating myeloproliferative tumors

A technology of compound Phellodendron amurense and bone marrow hyperplasia, applied in antitumor drugs, drug delivery, drug combination and other directions, can solve the problems of unreported application of compound Phellodendron liquid paint, achieve no toxic and side effects, reduce abnormal hyperplasia, and relieve splenomegaly big effect

Inactive Publication Date: 2022-01-28
SHANDONG HANFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Although the compound Phellodendron phellodendron liquid varnish has been widely used clinically, the application of compound Phellodendron phellodendron liquid varnish in myeloproliferative neoplasm-related diseases has never been reported in the existing applications

Method used

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  • Application of compound cortex phellodendri liquid liniment in preparation of medicine for treating myeloproliferative tumors
  • Application of compound cortex phellodendri liquid liniment in preparation of medicine for treating myeloproliferative tumors
  • Application of compound cortex phellodendri liquid liniment in preparation of medicine for treating myeloproliferative tumors

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0067] The preparation method includes the following steps:

[0068] (1) weight ratio weighed cork, forsythia, honeysuckle, dandelion and centipedes, extracted three times with boiling water; the first one hour, the second 45 minutes, the third 30 minutes;

[0069] (2) decoctions were combined, filtered and the filtrate concentrated to a clear paste relative density of 1.10;

[0070] (3) Ethanol was added, and the ethanol content was 70%, allowed to stand for 24 hours, filtered, the filtrate was concentrated to a mixed alcohol, and the liquid is obtained;

[0071] (4) Add the liquid obtained from step (3) to 1000 parts by weight, stir well, stand, refrigerated for 24 hours, filtered, filling, sterilizing,

Embodiment 1

[0072] Fang Huangbo liquid varnish complex toxicity to normal mice: Example 1

[0073] 1. Experimental animals:

[0074] Clean grade 8-week-old adult female C57 / BL6 mice, weighing 19-21 grams, Jinan Peng Yue provided by a laboratory animal breeding Co., animal certificate number: SYXK (Lu) 20200022.

[0075] 2, experimental groups:

[0076] After the animals adapt to the environment for one week, they were randomly divided into two groups weighed, i.e., control group and the administered group, n = 8.

[0077] 3, the method of administration:

[0078] PM administered mice and the control group mice were administered daily intraperitoneal injections administered group was 3-fold concentrated solution primer complex Fang Huangbo administration ratio 0.3mL / 20g body weight by continuous administration of 21 days, the control group with the administration time and route of administration group consistent with PBS buffer instead of the drug.

[0079] 4. OUTCOME MEASURES:

[0080] 4....

Embodiment 2

[0092] Example 2: EPO complex Fang Huangbo liquid varnish on myeloproliferative tumors high Induced polycythemia vera treatment of experimental disease

[0093] 1. Experimental animals:

[0094] Clean grade 8-week-old adult female C57 / BL6 mice, weighing 19-21 grams, is provided by Jinan Peng Yue experimental animal breeding Co., animal certificate number: SYXK (Lu) 20200022.

[0095] 2, experimental groups:

[0096] After the animals adapt to the environment for one week, weighed and then randomized into three groups, normal control group, model group and the administration model group, n = 8.

[0097] 3, polycythemia vera model method:

[0098] Using EPO high The mouse model of polycythemia vera.

[0099] EPO high Model as follows: mice were injected intraperitoneal injection of recombinant human erythropoietin, 5000UI / kg, injected once every two days for 21 days, the establishment of mouse erythrocytes increased mainly polycythemia vera, continuing every two days after injec...

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Abstract

The invention relates to application of a compound cortex phellodendri liquid liniment in preparation of a medicine for treating myeloproliferative tumors. The compound cortex phellodendri liquid liniment is found to have a good curative effect on myeloproliferative tumors for the first time, experimental verification is carried out on the myeloproliferative tumors, and animal experimental results show that application of the recurrent cortex phellodendri liquid liniment has a remarkable treatment effect on abnormal increase of various lines of cells of myeloproliferative model mice, so the liniment can be used for remarkably reducing abnormal cell rise caused by myeloproliferative tumors, relieving splenomegaly, regulating the hematopoietic function of a blood system and inhibiting the progress of primary thrombocythemia to myelofibrosis.

Description

Technical field [0001] The present invention relates to the application of compound cork coatings in the preparation of the treatment of bone marrow proliferative tumor drugs, belonging to the technical field of traditional Chinese medicine applications. Background technique [0002] Myelomensitic tumor (MPN) is a group of blood diseases that cause blood cell excessive proliferation in a group of blood cells. Bone marrow proliferative tumors are divided into two categories: the first category is the positive bone marrow proliferative tumors of Philadelphia, that is, chronic myeloid leukemia; another is classic Philadelphia chromosome neutral bone marrow proliferative tumor, including true red blood cells, Primary platelet increases and primary bone marrow fibrosis. Among them, it is also converted to bone marrow fibrosis in the later stage of the highlightean. Pathological symptoms such as myeloid hematopoietic, spleen swelling, thrombosis, bone marrow fiber variability due to ab...

Claims

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Application Information

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IPC IPC(8): A61K36/756A61K9/00A61P35/00A61K35/648
CPCA61K36/756A61K36/634A61K36/355A61K36/288A61K35/648A61K9/0019A61P35/00A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2300/00
Inventor 赵保兵刘明杰沈月毛鲁春华仕治达
Owner SHANDONG HANFANG PHARMA
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