A kind of daptomycin freeze-dried powder for injection and its production process
A technology of daptomycin and freeze-dried powder injection, which is applied in the field of medicine, can solve the problems of not inspecting the quality attributes of injection products, and not solving the problem of layering of liquid medicine, so as to speed up the dissolution time, prevent layering, and redissolve time short effect
Active Publication Date: 2021-04-27
KINDOS PHARM CO LTD +1
View PDF2 Cites 0 Cited by
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
This patent increases the stability of product content by adding buffer salts and stabilizers, and does not examine other key quality attributes of injection products, nor does it solve the problem of stratification of liquid medicine during the freeze-drying process
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View moreImage
Smart Image Click on the blue labels to locate them in the text.
Smart ImageViewing Examples
Examples
Experimental program
Comparison scheme
Effect test
Embodiment 1
[0027] A daptomycin freeze-dried powder for injection comprises, by mass, 70 parts of daptomycin, 5 parts of isopropanol and dilute to 1000 parts of water for injection.
Embodiment 2
[0029] A daptomycin freeze-dried powder for injection comprises, by mass, 100 parts of daptomycin, 15 parts of methanol and dilute water for injection to 1000 parts.
Embodiment 3
[0031] A daptomycin freeze-dried powder for injection comprises, by mass, 90 parts of daptomycin, 11 parts of tert-butanol and dilute water to 1000 parts.
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More PUM
Login to View More Abstract
The invention discloses a daptomycin freeze-dried powder for injection, which comprises 70-100 parts of daptomycin, 5-15 parts of an organic solvent and 1000 parts of water for injection in terms of mass. By adding a small amount of organic solvent, the product has high stability, uniform appearance and short reconstitution time.
Description
technical field [0001] The invention relates to the technical field of medicine, in particular to a daptomycin freeze-dried powder for injection. Background technique [0002] Daptomycin is a ring lipopeptide antibiotic with a new structure extracted from the fermentation broth of Streptomyces (S. Not only does it have a novel chemical structure, but its mode of action is also different from any approved antibiotic: it disrupts the transport of amino acids by the cell membrane, thereby hindering the biosynthesis of peptidoglycan in the bacterial cell wall, changing the properties of the plasma membrane, It can destroy the function of bacterial cell membrane in many ways, and quickly kill Gram-positive bacteria. In addition to its ability to act on most clinically relevant Gram-positive bacteria, daptomycin is more important for isolates that have shown resistance to methicillin, vancomycin, and linezolid in vitro. Potent activity, this property has very important clinical ...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More Application Information
Patent Timeline
Login to View More Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K38/12A61K47/10A61P31/04
CPCA61K9/0019A61K9/19A61K38/12A61K47/10A61P31/04
Inventor 屈倩倩史宣宇田欣欣
Owner KINDOS PHARM CO LTD