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Augmenting heart function after cardiac injury with exosomes derived from cortical bone stem cells

A technology of exosomes and sources, applied in the direction of artificial cell constructs, bone/connective tissue cells, animal cells, etc., can solve the problems of weakened survival and differentiation ability, weakened ability of cell integration, etc.

Pending Publication Date: 2020-05-01
TEMPLE UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, major limitations of this approach are the reduced ability of the donated stem cell population to proliferate, survive, and differentiate and the ability of the cells to integrate in the host environment

Method used

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  • Augmenting heart function after cardiac injury with exosomes derived from cortical bone stem cells
  • Augmenting heart function after cardiac injury with exosomes derived from cortical bone stem cells
  • Augmenting heart function after cardiac injury with exosomes derived from cortical bone stem cells

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experiment example

[0150] The present invention will be described in further detail with reference to the following Experimental Examples. These examples are provided for illustrative purposes only, and they are not intended to be limiting unless otherwise indicated. Accordingly, the invention should in no way be construed as limited to the following examples, but rather should be construed to cover any and all modifications which become apparent as a result of the teachings provided herein.

[0151] It is believed that one of ordinary skill in the art, using the foregoing description and the following exemplary embodiments, can make and use the invention and practice the claimed methods without further description. Accordingly, the following working examples should not be construed as limiting the remainder of this disclosure in any way.

Embodiment 1

[0152] Example 1: Isolation and Characterization of CBSC Exosomes

[0153] Secretion of paracrine factors that enhance cardioprotection of endogenous myocardium, neovascularization, and recruitment of endogenous stem cells that promote repair is a possible mechanism of stem cell-mediated cardiac repair (Tang et al., 2010, Circulation 121:293-305; Rota et al., 2008, Circ Res 103: 107-116; Zeng et al., 2007, Circulation 115: 1866-1875; Li et al., 2012, J Am Coll Cardiol 59: 942-953 ). Thus, exosomes, which appear to be a major part of paracrine effects, may offer an alternative to the use of cells as therapeutic agents.

[0154] Exosomes are outer membrane vesicles as small as 30-100 nm that have attracted much attention due to their ability to modulate molecular processes in target cells (De Jong et al., 2014, Frontiers in Immunology, 5:608). Exosomes may be enriched in various miRs, other non-coding RNAs and proteins that appear to be specific to the parental cell and its ...

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Abstract

The present invention provides an isolated population of cortical bone stem cell (CBSC)-derived exosomes, and compositions comprising the exosomes and / or RNA thereof which are used for promoting cardiac repair when being delivered to a diseased heart.

Description

[0001] References to related applications [0002] This application claims priority to U.S. Provisional Application No. 62 / 539,612, filed August 1, 2017, which is hereby incorporated by reference in its entirety. Background technique [0003] Ischemic injury of the heart, including myocardial infarction (MI), is a major health problem leading to structural and functional remodeling (Pfeffer et al., 1990, Circulation 81:1161-1172), and often ends in heart failure (Gomeze et al. ., 2001, Circulation 104:688-693). New therapies are needed to repair or replace damaged myocardial tissue to improve outcomes for MI patients. Stem cell therapy has the potential to repair the heart after ischemic injury. [0004] The mechanism of stem cell-mediated cardiac repair is still unclear. Numerous preclinical studies in animal models suggest that differentiation of injected cells into new cardiomyocytes is a potential mechanism of this repair (Smith et al., 2007, Circulation 115:896-908; Or...

Claims

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Application Information

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IPC IPC(8): A61P1/04A61P3/00C12N5/071C12N5/0775C12N5/0797C12N15/09
CPCC12N15/09C12N15/113C12N2310/141C12N2320/32A61P9/10A61K35/32C12N5/0662A61K9/127A61K31/7105C12N5/0668
Inventor 史蒂文·R·豪泽哈吉莫·科博萨迪亚·穆赫辛
Owner TEMPLE UNIVERSITY
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