Skin-whitening facial cleanser and preparation method thereof

A facial cleanser and whitening technology, which is applied in the field of whitening facial cleanser and its preparation, can solve the problems of poor water solubility, large gravitational force, affecting bioavailability and application, etc., and achieve the effect of improving skin tone, regulating water-oil balance, and removing skin stains

Inactive Publication Date: 2020-05-05
广州古泉生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Unfortunately, although phloretin has strong physiological activity, it is a planar molecule, the molecular packing is relatively tight, and the intermolecular attraction due to the hydrogen bond is relatively large, so the water solubility is poor (the solubility of phloretin in water is only 21.34 μg / mL), thus greatly affecting its bioavailability and application

Method used

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  • Skin-whitening facial cleanser and preparation method thereof
  • Skin-whitening facial cleanser and preparation method thereof
  • Skin-whitening facial cleanser and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0033] The preparation of embodiment 1~6 long-acting whitening facial cleanser, each component is mass fraction

[0034]

[0035]

[0036] The preparation method of the above-mentioned long-acting whitening milk comprises: 1) Weighing each raw material of formula components, phloretin, glycosylated phloretin, ursolic acid, hexapeptide-10, carnosine, D-panthenol, vitamin C and vitamin E are individually wrapped with hyaluronic acid-g-polyε-caprolactone derivative carrier nanomicelles, and then placed in a water bath at 55-65°C for 20-30 minutes at a constant temperature. After the water bath is over, the components are mixed ; 2) After mixing the rest of the components, mix them evenly with the mixture in step 1), stir slowly and cool down to room temperature naturally to obtain a composition for moisturizing the face.

Embodiment 7

[0038] Product safety performance evaluation test of the present invention is as follows: (human body skin patch test)

[0039] 1. Test product: the whitening facial cleanser prepared in Examples 1-6. Number of subjects: 60, female; age: between 20 and 30 years old; health status: subjects have healthy skin, no history of skin allergies, and meet the voluntary selection criteria for subjects. Grouping: 6 groups, 10 people in each group, with an average age of 25±2 years old.

[0040] 2. Patch method: Select a qualified patch tester, drop about 0.02g to 0.05g of the test substance into the patch tester in a closed patch test method, and stick the special tape for external use on the back of the subject, 24 After 1 hour, the test substance was removed, and the skin reaction was observed at 0.5, 6, 12, 24, and 48 hours after removal, and the results were recorded according to the skin reaction grading standard in the "Hygienic Standards for Cosmetics".

[0041] 3. Experimental ...

Embodiment 8

[0042] Example 8 Clinically evaluates the whitening and lightening effects of Examples 1-6

[0043]In this experiment, the whitening facial cleanser provided in Examples 1-6 was selected for the experiment.

[0044] Select 60 healthy women aged 23 to 50, measure the pigment content of their cheeks and skin color, and then distribute the test cosmetics. The test subjects used the whitening cleanser samples continuously. The tester used the left and right cheeks as a control experiment, and used it once a day in the morning and evening, and applied it after cleansing. Other whitening cosmetics were discontinued during the experiment. After continuous use for 7d, 14d, 21d, and 30d, measure each efficacy index. At the same time, ask the volunteers how they feel after using the test samples and whether they have allergies, etc., and record their own comparisons before and after. 1d before using the cosmetics and 7d, 14d, 21d, and 30d after using the cosmetics, the changes in sk...

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Abstract

The invention discloses a skin-whitening facial cleanser and a preparation method thereof. The skin-whitening facial cleanser contains components such as phloretin, glycosylated phloretin, hexapeptide-10, carnosine, laureth-23, allantoin, vitamin C and a hyaluronic acid-g-poly epsilon-caprolactone derivative carrier nano-micelle. The skin-whitening components phloretin and glycosylated phloretin are added and matched with base raw materials to prepare the skin-whitening facial cleanser, and the skin-whitening facial cleanser can go deep into skin bottom to remove melanin and free radicals andrecover the skin to the natural white state. The hyaluronic acid-g-poly epsilon-caprolactone derivative carrier nano-micelle is used as a phloretin carrier, has the capacity of rapidly being absorbedby the skin and penetrating through cell membranes, goes deep into the skin bottom to remove melanin and free radicals and recover the skin to the natural white state.

Description

technical field [0001] The invention belongs to the technical field of cosmetics, and in particular relates to a whitening facial cleanser and a preparation method thereof. Background technique [0002] The basal layer cells of the human epidermis contain 4% to 5% of pigment cells; the color of human skin does not depend on the number of melanocytes, but on the number, size, distribution and degree of melanization of melanosomes. Therefore, some whitening ingredients achieve the whitening effect by affecting the formation, maturation and transfer of melanosomes. [0003] The scientific name of Phloretin is 2,4,6-trihydroxy-3-(4-hydroxyphenyl)propiophenone, which is a flavonoid compound with a dihydrochalcone structure. Phloretin is mainly distributed in plant species such as apples and pears in the form of its glycoside (phloridin), and its content is relatively high in the roots and trunk epidermis of fruit trees such as apples and pears, and is a characteristic phenolic s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/35A61K8/73A61K8/85A61K8/02A61K8/63A61K8/64A61K8/67A61K8/42A61K8/86A61Q19/02A61Q19/10
CPCA61K8/0291A61K8/35A61K8/42A61K8/63A61K8/64A61K8/676A61K8/678A61K8/735A61K8/85A61K8/86A61K2800/56A61K2800/592A61K2800/5922A61K2800/782A61Q19/02A61Q19/10
Inventor 范泽浩貌惠玲
Owner 广州古泉生物科技有限公司
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