Pharmaceutical composition containing extract of leaves of v accinium bracteatum thunb. for prevention or treatment of stress disease and depression
A technology for stress diseases and leaves of fenugreek, which is applied in the field of pharmaceutical compositions for preventing or treating stress diseases and depression containing the extract of fenugreek leaves, and can solve the problems of nutritional value or physiological activity. Insufficient relevant information and other problems, to achieve the effect of outstanding antidepressant effect, lower manufacturing cost, and high antidepressant effect
Pending Publication Date: 2020-05-05
JEONNAM BIOIND FOUND
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Problems solved by technology
In particular, with active research on health foods containing nutrients required by the human body or natural functional substances that are particularly helpful for disease prevention and recovery, investigations into the black rice tree or its functions are being carried out, but so far , information on nutritional value or physiologically active functions is still insufficient
Method used
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[0028] 1. Preparation of hot water extract from leaves
[0029] 8 L of distilled water was added to 400 g of black rice leaves, and the temperature was raised from 100° C. using a reflux extractor, followed by heating and extraction for 3 hours. The obtained extract was filtered under reduced pressure and concentrated under reduced pressure to obtain 31.52 g of a concentrate.
[0030] 2. Preparation of 80% methanol extract from the leaves of Wufan tree
[0031] 20 L of 80% methanol was added to 20 g of black rice leaves, and the temperature was raised from 100° C. using a reflux extractor, followed by heating and extraction for 3 hours. The obtained extract was filtered under reduced pressure and concentrated under reduced pressure to obtain 6.99 g of a concentrate.
[0032] 3. Experimental animals and feeding
[0033] 6-week-old male ICR mice were purchased from SAMTACO (Korea) as experimental animals for measuring the antidepressant effect of the leaf extract of A. It wa...
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The present invention provides a pharmaceutical composition for prevention or treatment of a stress disease and depression, the pharmaceutical composition being safely usable without toxicity and sideeffects by using an extract of leaves of Vaccinium bracteatum Thunb, which is natural resource of Korea, so that the reduction of manufacturing and production costs and the import substitution and export effects can be expected through the replacement of a raw material for preparation with a plant inhabiting in nature.
Description
technical field [0001] The present invention relates to a pharmaceutical composition for preventing or treating stress disease and depression comprising an extract of leaves of Vaccinium bracteatum Thunb. The leaf extract is a pharmaceutical composition for preventing or treating stress diseases and depression, which is non-toxic, has no side effects and can be used safely. Background technique [0002] The uneasiness and dangerous emotions that people feel when they are in a psychologically or physically unbearable situation are called stress. As a stress response, psychological reactions such as anxiety, depression, and anxiety, or physical reactions such as loss of appetite appear. [0003] Depression is a disease in which low will and depression are the main symptoms, causing various cognitive, mental and physical symptoms and leading to a decline in daily functioning. Depressive disorder is a serious illness that causes changes in feelings, thoughts, physical condition...
Claims
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IPC IPC(8): A61K36/45A61K9/20A61K9/48A61K9/16A61K9/08
CPCA61K9/20A61K36/45A61P25/24A61P25/22A61K31/343A61K9/0019A61K47/26A61K9/16A61K9/08A61K9/48
Inventor 崔徹雄吴乧理金瑜真崔银珍李铉美裴董赫吴教女郑明我洪榰埃金光洙姜厚远金栽龙潘相吾朴成伦成乐宣
Owner JEONNAM BIOIND FOUND