Preparation method of nanocapsules carrying fat-soluble active substances

An active, fat-soluble technology, used in organic active ingredients, preparations for skin care, medical preparations with non-active ingredients, etc., can solve the problems of affecting the use effect, unstable nanocapsule ions, etc. Beneficial for transdermal absorption and good occlusive effect
CN111110587APending Publication Date: 2020-05-08JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2020-05-08

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Abstract

The invention discloses a preparation method of nanocapsules carrying fat-soluble active substances. The nanocapsules comprise liquid lipids, solid lipids, fat-soluble active substances, phospholipids, nonionic emulsifiers, polyols and water. In percentage by weight, the nanocapsules comprise 0.1-20% of liquid lipids, 0-20% of solid lipids, 0.1-15% of fat-soluble active substances, 0.1-10% of phospholipids, 0.1-5% of nonionic emulsifiers, 40-90% of polyols and the balance of water. The nanocapsules are made by dispersing the raw materials at high pressure and conducting homogenization. The solid lipids in the nanocapsules have high crystallinity, and a dense film can be formed on the skin surface, so that the nanocapsules have better closing effect, reduce the evaporation of moisture on the skin surface, improve hydration level of the skin surface, and loosen a stratum corneum structure, thereby facilitating transdermal absorption of the active substances.
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Description

technical field

[0001] The invention belongs to the technical field of micro-nano carriers, and in particular relates to a preparation method of nanocapsules carrying fat-soluble active substances. Background technique

[0002] Micro-nano carrier technology is a technology to protect and deliver active ingredients with low solubility, poor stability, and low availability. Using materials with good biocompatibility to prepare micro-nano carriers, embedding active substances in the interior of micro-nano carriers or adsorbing them on the surface through adsorption, dissolution, etc., is an effective technology for protecting and transporting active ingredients . Compared with chemical modification technology, micro-nano carrier technology basically does not affect the functional properties of active ingredients, and the operation method is relatively simple.

[0003] Commonly used micro-nano carriers mainly include nanoemulsions, nanostructured lipid carriers, lipid nanocaps...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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