Bacterial cellulose composite membrane for medical dressings and preparation method thereof

A technology of bacterial cellulose and composite membrane, applied in the fields of medical science, bandages, absorbent pads, etc., can solve the problems of poor antibacterial performance, single structure, poor functionality, etc., and achieve improved antibacterial properties, many reaction sites, and excellent mechanical properties. Effect

Pending Publication Date: 2020-05-19
黄旭萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

This patented technology describes an improved type of chemical called bacteria cellulosic (BCC) that uses specialized molecules made from chitins or sugars attached together like sugar rings. These modifications make BCC more effective at capturing metal ion(Ag+) than traditional methods such as precipitation techniques. By adding these modifying agents during manufacture, this new compound becomes better able to bind metals onto its surfaces when exposed to certain conditions. Additionally, there're several ways how this modification works, making them useful in various industries including medicine, food processing, electronics, etc., providing technical benefits over existing materials.

Problems solved by technology

This patented technology describes how bacterium cells called Bacillus spores can produce different types of small molecules like enzyme or protein inside them when exposed to specific conditions. These tiny particles are made up from these special chemical structures - they hold large amounts of liquid even without any other substances added – making their way through blood vessels on Earth more difficult compared to traditional methods involving synthetic polymers.

Method used

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  • Bacterial cellulose composite membrane for medical dressings and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] S1: Prepare materials:

[0047] Weigh bacterial cellulose, sodium periodate, chitosan, polyvinyl alcohol, silver nitrate solution, graphene oxide solution, crosslinking agent, sodium thiosulfate, isopropanol, sodium hydroxide and chloroacetic acid in proportion, spare;

[0048] Weigh acrylamide, N,N-methylenebisacrylamide, ammonium persulfate, sodium alginate, calcium chloride and collagen in proportion, and set aside;

[0049] S2: Preparation of modified bacterial cellulose:

[0050] Take bacterial cellulose, dissolve it in deionized water, stir for 10 minutes, then add sodium periodate, oxidize at 50°C for 6 hours, filter with suction, wash and dry to obtain modified bacterial cellulose.

[0051] : Preparation of chitosan microspheres:

[0052] Take chitosan, dissolve chitosan in acetic acid to obtain chitosan acetic acid solution; dissolve polyvinyl alcohol in deionized water to obtain polyvinyl alcohol aqueous solution; take chitosan acetic acid solution and poly...

Embodiment 2

[0061] S1: Prepare materials:

[0062] Weigh bacterial cellulose, sodium periodate, chitosan, polyvinyl alcohol, silver nitrate solution, graphene oxide solution, crosslinking agent, sodium thiosulfate, isopropanol, sodium hydroxide and chloroacetic acid in proportion, spare;

[0063] Weigh acrylamide, N,N-methylenebisacrylamide, ammonium persulfate, sodium alginate, calcium chloride and collagen in proportion, and set aside;

[0064] S2: Preparation of modified bacterial cellulose:

[0065] Take bacterial cellulose, dissolve it in deionized water, stir for 15 minutes, then add sodium periodate, oxidize at 55°C for 6.5 hours, filter with suction, wash and dry to obtain modified bacterial cellulose.

[0066] : Preparation of chitosan microspheres:

[0067] Take chitosan, dissolve chitosan in acetic acid to obtain chitosan acetic acid solution; dissolve polyvinyl alcohol in deionized water to obtain polyvinyl alcohol aqueous solution; take chitosan acetic acid solution and po...

Embodiment 3

[0076] S1: Prepare materials:

[0077] Weigh bacterial cellulose, sodium periodate, chitosan, polyvinyl alcohol, silver nitrate solution, graphene oxide solution, crosslinking agent, sodium thiosulfate, isopropanol, sodium hydroxide and chloroacetic acid in proportion, spare;

[0078] Weigh acrylamide, N,N-methylenebisacrylamide, ammonium persulfate, sodium alginate, calcium chloride and collagen in proportion, and set aside;

[0079] S2: Preparation of modified bacterial cellulose:

[0080] Take bacterial cellulose, dissolve it in deionized water, stir for 20 minutes, then add sodium periodate, oxidize at 60°C for 7 hours, filter with suction, wash and dry to obtain modified bacterial cellulose.

[0081] : Preparation of chitosan microspheres:

[0082] Take chitosan, dissolve chitosan in acetic acid to obtain chitosan acetic acid solution; dissolve polyvinyl alcohol in deionized water to obtain polyvinyl alcohol aqueous solution; take chitosan acetic acid solution and poly...

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Abstract

The invention discloses a bacterial cellulose composite membrane for medical dressings and a preparation method thereof. The composite membrane is prepared from a pretreated membrane and a silver nitrate solution, the prepared composite membrane is soaked in the silver nitrate solution, ultraviolet reduction is conducted through irradiation of an ultraviolet lamp, nano-silver particles are generated, and the antibacterial performance of the composite membrane is further improved. The pretreated membrane is prepared from the following raw materials in parts by weight: 10 to 15 parts of modifiedchitosan microspheres, 15 to 28 parts of modified bacterial cellulose, 10 to 12 parts of acrylamide, 6 to 12 parts of N, N-methylene bisacrylamide, 2 to 5 parts of ammonium persulfate, 7 to 10 partsof sodium alginate, 4 to 6 parts of calcium chloride and 6 to 9 parts of collagen. The bacterial cellulose membrane is reasonable in component design and simple in technological operation, preparationof the bacterial cellulose membrane is effectively achieved, the bacterial cellulose membrane has excellent antibacterial performance and excellent mechanical performance, and the bacterial cellulosemembrane can be applied to the fields of medical treatment, biology and the like and is wide in application prospect.

Description

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Claims

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Application Information

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Owner 黄旭萍
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