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Biomarker for monitoring and therapeutic effect evaluation of head and neck cancer

A technology for efficacy evaluation and head and neck cancer, applied in the direction of microbial measurement/testing, biochemical equipment and methods, etc., can solve the problems of disfigurement or disability, poor diagnosis awareness of patients, and no significant improvement in the 5-year survival rate of head and neck cancer patients. Achieve accurate judgment and high specificity

Pending Publication Date: 2020-05-19
THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, due to the poor diagnostic awareness of patients and the common symptoms of distant metastasis or recurrence in patients, the clinical early diagnosis and comprehensive treatment of head and neck squamous cell carcinoma are still greatly limited, and the average survival period of head and neck squamous cell carcinoma patients is only 5 years.
[0003] After decades of development, surgery, radiotherapy and chemotherapy have not significantly improved the 5-year survival rate of head and neck cancer patients, and due to the special anatomical site, the resection range of head and neck cancer surgical treatment is severely limited, and the quality of life of patients generally declines after treatment , often disfiguring or disabling

Method used

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  • Biomarker for monitoring and therapeutic effect evaluation of head and neck cancer
  • Biomarker for monitoring and therapeutic effect evaluation of head and neck cancer
  • Biomarker for monitoring and therapeutic effect evaluation of head and neck cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] The application of m5C regulatory genes in the preparation of reagents or kits for the diagnosis, monitoring, efficacy evaluation, or metastasis and recurrence monitoring of head and neck cancer; the changes of m5C regulatory genes are significantly associated with the changes of HRAS and RAC1; the m5C regulatory genes tend to be high in high TNMStage cases Express.

[0088] m5C-regulated genes include:

[0089] Writers, methylases, RNA methylation modification process, currently known components are NSUN1, NSUN2, NSUN3, NSUN4, NSUN5, NSUN6, NSUN7, DNMT1, DNMT2, DNMT3A and DNMT3B;

[0090] Erasers, demethylases, have TET2;

[0091] Readers, m5C binding protein, recognize and bind to the m5C site on mRNA, there is ALYREF.

[0092] Among the m5C-regulated genes, the expression of Eraser and Reader genes were significantly correlated with CNV.

Embodiment 2

[0094] The application of the DNMT1 gene in the preparation of reagents or kits for the diagnosis, monitoring, curative effect evaluation or monitoring of metastasis and recurrence of head and neck cancer; the high expression of the ALYREF gene are all related to the poor prognosis of HNSCC patients.

[0095] The reagent or kit includes primers specifically recognizing DNMT1 gene or primers or probes specifically recognizing DNMT1 protein nucleic acid.

[0096] Preferably, low expression of DNMT1 gene is associated with poor prognosis of HNSCC patients, and high expression of DNMT1 gene is associated with peptide cross-linking and humoral immunity.

Embodiment 3

[0098] The application of the ALYREF gene in the preparation of reagents or kits for the diagnosis, monitoring, curative effect evaluation, or metastasis and recurrence monitoring of head and neck cancer; the high expression of the ALYREF gene is related to the poor prognosis of HNSCC patients; the high expression of the ALYREF gene is related to the mitochondrial physiological function.

[0099] The reagent or kit includes primers specifically recognizing ALYREF gene or primers or probes specifically recognizing ALYREF protein nucleic acid.

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Abstract

The invention relates to the field of clinical diagnosis of head and neck cancer, in particular to a biomarker for monitoring and therapeutic effect evaluation of the head and neck cancer. The invention discloses application of an m5C regulatory gene in preparation of a monitoring reagent or kit for diagnosis, monitoring, therapeutic effect evaluation or metastasis and recurrence. The biomarker has high specificity in monitoring and therapeutic effect evaluation of the head and neck cancer, and can be used for dynamic monitoring of recurrence and metastasis. The gene marker can be combined with other clinical indicators, and provide more accurate judgments for screening, diagnosis, therapy and prognosis of the head and neck cancer.

Description

technical field [0001] The invention relates to the field of clinical diagnosis of head and neck cancer, in particular to a biomarker used for monitoring and evaluating the curative effect of head and neck cancer. Background technique [0002] Head and neck cancer is the seventh malignant tumor type in tumor diseases, accounting for about 7% of human body malignant tumor diseases, and more than 90% of head and neck cancers belong to head and neck squamous cell carcinoma (HNSCC). More than 500,000 patients are diagnosed with head and neck squamous cell carcinoma every year, and the number of new cases in China accounts for about 1 / 5 of them, and the number of deaths is about 56,000 each year. Head and neck squamous cell carcinoma is generally divided into oral cancer, nasopharyngeal cancer, oropharyngeal cancer and laryngeal cancer. At the same time, since about a quarter of head and neck squamous cell carcinoma patients are associated with human papillomavirus infection (es...

Claims

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Application Information

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IPC IPC(8): C12Q1/6886
CPCC12Q1/6886C12Q2600/158
Inventor 薛苗苗郑廉李庆宾张媛媛
Owner THE FIRST AFFILIATED HOSPITAL OF ZHENGZHOU UNIV
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