Topical semisolid composition containing antimicrobial agent and pirfenidone for treatment of chronic skin damage

An antimicrobial agent, a technology for skin damage, applied in the field of treating the chronic skin damage, and preparing a local pharmaceutical composition in the form of a gel, which can solve the problems of low ability to induce resistance, limited therapeutic application, poor stability, etc.

Pending Publication Date: 2020-06-05
CELL THERAPY & TECH S A DE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0040] 3. Low ability to induce resistance
[0051] The activity of allicin was demonstrated in several studies published in reference journals; however, its poor stability has limited its possible therapeutic applications

Method used

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  • Topical semisolid composition containing antimicrobial agent and pirfenidone for treatment of chronic skin damage
  • Topical semisolid composition containing antimicrobial agent and pirfenidone for treatment of chronic skin damage
  • Topical semisolid composition containing antimicrobial agent and pirfenidone for treatment of chronic skin damage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0118] Example 1. Topical formulation of gel

[0119] Prepare a gel composition comprising:

[0120] Element g Pirfenidone 8 M-DDO 0.016 Carbomer 940 1 Propylene Glycol 40 Triethanolamine 1 Appropriate amount of purified water 100

Embodiment 2

[0122] A second composition is prepared comprising the following ingredients:

[0123]

Embodiment 3

[0125] A third composition was prepared comprising the following ingredients:

[0126] Element g Pirfenidone 8 M-DDO 0.016 Carbomer 940 1.00 Propylene Glycol 50 Triethanolamine 1.00 Appropriate amount of purified water 100 Macrogol Glyceryl-Hydroxystearate 40 13

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PUM

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Abstract

The invention provides a topical pharmaceutical gel composition. The topical medicinal gel composition is used for treating chronic skin injury, and is especially used for treating injuries caused byneurological ulcers. The present invention relates to the topical pharmaceutical gel composition for treating vascular ulcers, preferably diabetic feet, and for treating vascular ulcers, in which thecomposition comprises a combination of a modified diallyl disulfide oxide (M-DDO) (as preservative / antibiotic) and 5-methyl-1-phenyl-2 (1H)-pyridone. Furthermore, the present invention describes therapeutic methods, uses and / or uses for the preparation of medicaments for eliminating, reducing or preventing chronic skin lesions and lesions caused by neurological ulcers, in particular for the treatment of diabetic feet and for the treatment of vascular ulcers.

Description

technical field [0001] The present invention relates to a topical semisolid (water soluble) pharmaceutical composition in the form of a gel comprising a combination of 5-methyl-1-phenyl-2(1H)pyridone and an antimicrobial agent which is: Diallyl disulfide oxide (M-DDO), said composition is useful for the treatment of chronic skin lesions, especially skin ulcers or vascular ulcers which may be derived from diabetes. In addition, the present invention also relates to methods for treating said chronic skin lesions and methods for preparing topical pharmaceutical compositions in gel form. Background technique [0002] The word ulcer comes from the plural form of the Latin ulcer (ulcus, sore). It is defined as a continuous solution that loses material from any epithelial surface of the organism with little tendency for spontaneous healing. Definitions of more specific pathological processes are also accepted, such as loss of skin or mucous material, the result of a pathological ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K47/10
CPCA61K36/8962A61K9/0014A61K47/10A61K9/06A61K47/32A61P17/02A61K31/351A61K31/4418A61K45/06Y02A50/30A61K2300/00
Inventor J·A·R.马加纳卡斯特罗J·S·阿门达里兹博伦达
Owner CELL THERAPY & TECH S A DE
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