Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

A kind of celery seed oil solid dispersion and preparation method thereof

A technology of solid dispersion and celery seed oil is applied in the directions of medical preparations without active ingredients, medical preparations containing active ingredients, pharmaceutical formulas, etc., and can solve the problems of poor water solubility and volatile nature of celery seed oil, To achieve the effect of increasing the effective dose of essential oils, inhibiting volatilization, and shortening the preparation time

Active Publication Date: 2022-02-11
ZHEJIANG UNIV OF TECH
View PDF3 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Aiming at problems such as poor water solubility and volatility of celery seed oil existing in the prior art, the object of the present invention is to provide a kind of celery seed oil solid dispersion and preparation method thereof, which can improve the dissolution rate of celery seed oil aqueous solution, And reduce its volatility, avoid the use of organic solvents in its preparation, meet the requirements of green environmental protection

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of celery seed oil solid dispersion and preparation method thereof
  • A kind of celery seed oil solid dispersion and preparation method thereof
  • A kind of celery seed oil solid dispersion and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Example 1: Preparation of solid dispersion with hydroxypropyl-β-cyclodextrin as carrier (1:10)

[0033] Add hydroxypropyl-β-cyclodextrin (6.0g) into a beaker, add distilled water to saturation, slowly add celery seed oil (0.6g), stir continuously for 30min, and then filter. The filtrate was spray-dried, the air inlet temperature was 140°C, the injection volume was 1000ml / h, the atomization pressure was 2.5BAR, the air outlet temperature was 85°C, and the fan power was 1.0KW. A solid dispersion of celery seed oil was obtained. Take an appropriate amount of the powder and place it in an Erlenmeyer flask, add 10 mL of distilled water, and shake for 24 hours on a shaker at 37°C and 150 rpm. After taking the supernatant and passing through a 0.45 μm membrane, use high performance liquid chromatography to detect the concentration of the main antibacterial components apigenin and limonene, as the solubility of apigenin and limonene. The test results show that the prepared cel...

Embodiment 2

[0034] Example 2: Preparation of solid dispersion with α-cyclodextrin as carrier (1:10)

[0035] Add α-cyclodextrin (6.0 g) into the beaker, add distilled water to saturation, slowly add celery seed oil (0.6 g), keep stirring for 30 min and then filter. The filtrate was spray-dried, the air inlet temperature was 140°C, the injection volume was 1000ml / h, the atomization pressure was 2.5BAR, the air outlet temperature was 85°C, and the fan power was 1.0KW. A solid dispersion of celery seed oil was obtained. The steps of solubility measurement are the same as in Example 1, and the test results show that the solubility of apigenin A in the prepared celery seed oil solid dispersion is 5.10g / L, and the solubility of limonene is 6.78g / L.

Embodiment 3

[0036] Example 3: Preparation of solid dispersion with β-cyclodextrin as carrier (1:10)

[0037] Add β-cyclodextrin (6.0g) into the beaker, add distilled water to saturation, slowly add celery seed oil (0.6g), keep stirring for 30min and then filter. The filtrate was spray-dried, the air inlet temperature was 140°C, the injection volume was 1000ml / h, the atomization pressure was 2.5BAR, the air outlet temperature was 85°C, and the fan power was 1.0KW. A solid dispersion of celery seed oil was obtained. The solubility detection step is the same as in Example 1. The test results show that the solubility of apigenin A in the prepared celery seed oil solid dispersion is 2.82g / L, and the solubility of limonene is 3.34g / L.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a celery seed oil solid dispersion and a preparation method thereof. The powdery solid obtained after spray-drying by the saturated aqueous solution of celery seed oil and macromolecular carrier material is mixed homogeneously; The mass ratio of celery seed oil and macromolecular carrier material in the described solid dispersion is 1:1- 100; the polymer carrier material is selected from arabinogalactan, hydroxyethyl starch, polyvinylpyrrolidone K30, hyaluronic acid, α-cyclodextrin, β-cyclodextrin, hydroxypropyl-β-cyclodextrin One of the alcohols or methyl-β-cyclodextrin. The invention obtains dry fine powder particles through spray drying, forms complexes through the inclusion action of carriers, and suppresses volatilization of celery seed oil. It has a significant effect on lowering uric acid and blood pressure. It can increase the effective dose of essential oils and cover up its irritating smell, reducing the irritation to human mucous membranes. The market prospect is broad.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a solid dispersion of celery seed oil capable of increasing the dissolution rate of an aqueous solution of celery seed oil and reducing its volatility and a preparation method thereof. Background technique [0002] With the improvement of people's living standards, the pressure of life increases, and people do not pay attention to lifestyle and eating habits, so that the number of people with hyperuricemia and the three highs continues to increase, but the existing chemical drugs are still unable to treat them well , long-term medication is required, and the side effects are relatively large. Therefore be badly in need of a kind of safe and effective medicine health care product and it is prevented and treated. [0003] Celery seed oil is a brown-green oily liquid distilled and extracted from the seeds of the umbelliferous plant celery (Apium grav...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/14A61K36/23A61K47/40A61K47/36A61K47/32A61K47/69A61P3/06A61P9/12A61K131/00
CPCA61K36/23A61K47/40A61K47/36A61K47/32A61K47/6951A61K47/6949A61P3/06A61P9/12A61K2236/35A61K2236/39
Inventor 许文灏梁明利苏为科
Owner ZHEJIANG UNIV OF TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com