Unlock instant, AI-driven research and patent intelligence for your innovation.

Preparation method and novel medical application of myricetin derivatives

A technology of derivatives and drugs, applied in the field of medicine, can solve the problems of undiscovered reports on the application of myricetin derivatives

Pending Publication Date: 2020-06-16
CHANGCHUN UNIV OF CHINESE MEDICINE
View PDF2 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Before the completion of the present invention, there was no literature report that the derivatives of cyclomyricetin have anti-Alzheimer's disease effects, and no reports on the application of myricetin derivatives in the preparation of anti-Alzheimer's disease drugs have been found.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Preparation method and novel medical application of myricetin derivatives
  • Preparation method and novel medical application of myricetin derivatives
  • Preparation method and novel medical application of myricetin derivatives

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 2

[0041] Embodiment 2 compound 1-16 preparation method

[0042] Dissolve 1mmol myricetin and 1.2mmol amino-containing compound in 20mL of absolute ethanol, add a small amount of glacial acetic acid dropwise, stir and reflux the mixture for 36-48h, check the reaction progress by thin-layer chromatography, and obtain a brown-yellow solution, remove part of it under reduced pressure Ethanol, a yellow solid precipitated, suction filtered, washed the solid with distilled water, and then washed with a small amount of ethanol, dried at room temperature, and recrystallized from absolute ethanol to obtain the corresponding myricetin derivative 1-16. The yields were all greater than 85%.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

Myricetin which is obtained by extraction, separation and purification from Ampelopsis grossedentata (Hand.-Mazz.) W.T. Wang is adopted as a lead compound, and is subjected to a condensation reactionwith amino-containing compounds such as phenylhydrazine, benzoyl hydrazine, phenylaminourea, phenylthiosemicarbazide, phenylacetylhydrazine, phenoxyacethydrazide and phenylaminoacethydrazide to obtainmyricetin derivatives. Enzymology and cell tests prove that the myricetin derivatives have a relatively strong effect of inhibiting acetylcholin esterase, so that the effect of preventing and treating Alzheimer's disease is achieved. Further research shows that the activity of most myricetin derivatives is higher than that of the lead compound.

Description

technical field [0001] The invention relates to a series of derivatives of myricetin obtained from natural Chinese medicine as a lead compound through a synthesis reaction, to be exact, a series of derivatives prepared by taking chemical components extracted from traditional Chinese medicine as lead compounds The invention relates to structural modification for the purpose of anti-Alzheimer's disease activity, and belongs to the field of medicine. Background technique [0002] Alzheimer's disease (AD) is a common degenerative disease of the central nervous system characterized by progressive memory loss, cognitive dysfunction, and personality changes in middle-aged and elderly people. Intensified, the global number of Alzheimer's patients has exceeded 35 million, which will bring many social and economic problems. Therefore, the prevention and treatment of AD has become a very urgent social and medical problem. At present, there are many kinds of drugs for the treatment of...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C07D311/68A61P25/28
CPCC07D311/68A61P25/28
Inventor 赫玉芳段明华李海燕于露宁春雪姚佩欣南敏伦
Owner CHANGCHUN UNIV OF CHINESE MEDICINE
PatSnap Eureka logo

PatSnap Eureka turns technology decisions into work you can execute. Powered by our Innovation Knowledge Graph, it runs expert workflows across engineering, life sciences, materials and intellectual property. Get your review-ready output in minutes.

X (Twitter)LinkedInYouTubeSubstack

© 2026 PatSnap. All rights reserved. 

Terms of Service

 | 

Privacy policy

 | 

Modern Slavery Act Transparency Statement