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Radix ginseng and radix angelicae sinensis blood-nourishing tablet traditional Chinese medicine preparation and preparation and detection methods thereof

A technology for traditional Chinese medicine preparations and detection methods, which is applied in pharmaceutical formulations, drug combinations, blood diseases, etc., can solve problems such as high requirements for particle size and uniformity, increased production costs, and increased difficulty in granulation and tableting.

Active Publication Date: 2020-06-23
SHAANXI DONGKE PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The original process has the following problems: (1) Ginseng, Atractylodes macrocephala, and rhubarb are directly used as medicine after being crushed, which is not conducive to the absorption of active ingredients; (2) The granulation process has high requirements for particle size and uniformity, and the direct crushing of medicinal materials into medicine will easily cause uneven distribution Uniformity increases the difficulty of granulation and tableting; (3) cannot guarantee the full extraction of active ingredients, and the transfer rate is low, which is not conducive to the rational utilization of resources and increases production costs

Method used

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  • Radix ginseng and radix angelicae sinensis blood-nourishing tablet traditional Chinese medicine preparation and preparation and detection methods thereof
  • Radix ginseng and radix angelicae sinensis blood-nourishing tablet traditional Chinese medicine preparation and preparation and detection methods thereof
  • Radix ginseng and radix angelicae sinensis blood-nourishing tablet traditional Chinese medicine preparation and preparation and detection methods thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] 1. Preparation of extract A: Weigh 50g of ginseng, 200g of Astragalus membranaceus, and 50g of Ligustrum lucidum, respectively, and make 3 copies in parallel, and compile them into 1 to 3 experiment numbers, and extract 3 times with 80% ethanol under reflux, and the amount of alcohol added is the mass of medicinal materials respectively 8 times, 6 times, 4 times of that, every 2 hours, collect the extract, measure the amount of dry paste, ginsenoside Re, ginsenoside Rg1, and privetin component content, the experimental results are shown in Table 1. Combine the extracts, filter, recover ethanol under reduced pressure at -0.04Mpa and 70°C, and concentrate to an extract with a relative density of 1.10 to 1.15, which is the density at 60°C.

[0060] Table 1 Statistical table of the experimental results of extracting ginseng, astragalus, and privet lucidum

[0061]

[0062] 2. Preparation of extract B: Weigh 50g of medlar and 50g of oyster respectively, 3 parts each, and ...

Embodiment 2

[0073] 1. Preparation of extract A: feed intake according to 300 times of the prescription amount, reflux extraction with 80% ethanol for 3 times, the first addition of ethanol is 8 times the quality of the medicinal material, and extract for 2 hours; the second addition of ethanol is the medicinal material 6 times the mass, extract for 2 hours; the third addition of ethanol is 4 times the mass of medicinal materials, extract for 2 hours; combine the extracts, filter, and decompress the extracts at 70°C to a thick paste (111.8kg), relative density It is 1.10 to 1.15 (60°C).

[0074] 2. Preparation of extract B: Feed 300 times the amount of the prescription, extract twice by reflux of tap water, add 8 times the quality of the medicinal material for the first time, and extract for 2 hours; 6 times, extract for 2 hours; combine the extracts, filter, and concentrate under reduced pressure at 70°C to a thick paste (60.4kg), with a relative density of 1.10-1.15 (60°C).

[0075]3. P...

Embodiment 3

[0081] 1. The HPLC method determination of the privetin component

[0082] (1) Source and purity inspection of the reference substance: privetin reference substance (batch number: 111926-201404, for content determination, purchased from China National Institute for Food and Drug Control). The content determined by HPLC normalization method is 97.30%.

[0083] Selection of measurement wavelength: take the privetin reference substance solution, and use a UV-visible spectrophotometer to scan and measure from the wavelength range of 200 to 400nm. The scanning results showed that tervinetin had the maximum absorption at the wavelength of 224nm, therefore, it was determined that 224nm was the detection wavelength for detecting tervinetin.

[0084] Chromatographic conditions: chromatographic column: AgilentXDB-C18 column, 250×4.6mm, 5μm; mobile phase: methanol-0.8% phosphoric acid solution (35:65); detection wavelength is 224nm; column temperature: 30°C. Under these conditions, the...

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Abstract

The present invention discloses a radix ginseng and radix angelicae sinensis blood-nourishing tablet traditional Chinese medicine preparation and preparation and detection methods thereof. The preparation method comprises the following steps of (1) taking radix ginseng, radix astragali and fructus ligustri lucidi, and performing reflux extraction of 80% ethanol thrice to prepare extract A; (2) taking fructus lycii and concha ostreae, adding water and performing reflux extraction twice to prepare extract B; (3) taking rhizoma atractylodis macrocephalae, fructus schisandrae, radix angelicae sinensis, radix polygoni multiflori, rheum officinale and radix aucklandiae, performing reflux extraction of 75% ethanol thrice, adding water and collecting precipitates to prepare extract C; and (4) mixing the extracts, performing reduced pressure drying at 70 DEG C, crushing a mixture into fine powder, adding a proper amount of starch, performing granulating, performing drying at 60 DEG C, adding magnesium stearate, and performing uniform mixing, tabletting and sugar-coating or film-coating. The detection method comprises thin layer chromatography identification of the radix astragali, the radixangelicae sinensis, rhizoma ligustici chuanxiong, the rheum officinale, the radix polygoni multiflori, the fructus schisandrae, the fructus lycii and the fructus ligustri lucidi, and high performanceliquid chromatography of specnuezhenide and ginsenoside content. Group extraction is adopted, and effective ingredients can be enriched, thereby improving the curative effect of a product.

Description

technical field [0001] The invention belongs to the technical field of preparation of Chinese patent medicines, and in particular relates to a traditional Chinese medicine preparation of Shengui Yangxue Tablets, a preparation method and a detection method thereof. Background technique [0002] Shengui Yangxue Tablets are made from ginseng, astragalus, Atractylodes macrocephala, schisandra, angelica, Chuanxiong, Ligustrum lucidum, etc. It has the effects of nourishing qi and blood, strengthening the spleen and kidney, and is used for dizziness and palpitations caused by deficiency of both qi and blood. Insomnia, fatigue, shortness of breath, anorexia embolism. It has certain curative effect on leukopenia and anemia. The original technology of Shengui Yangxue Tablets is a preparation produced under the guidance of the theory of traditional Chinese medicine, using Chinese medicinal materials as raw materials, and in accordance with the prescribed prescription, production proce...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/815A61K9/20A61P1/08A61P7/06A61P9/06A61P25/20G01N30/02G01N30/90A61K35/618
CPCA61K36/258A61K36/481A61K36/284A61K36/79A61K36/57A61K36/232A61K36/236A61K36/638A61K35/618A61K36/815A61K36/704A61K36/708A61K36/285A61K9/2059A61P1/08A61P9/06A61P25/20A61P7/06G01N30/02G01N30/90A61K2236/333A61K2236/39A61K2236/331A61K2236/53A61K2236/51A61K2300/00
Inventor 王芳杜杉夏传涛刘桂端徐军
Owner SHAANXI DONGKE PHARMA
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