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Subject-specific tumor inhibiting cells and the use thereof

A subject and cell technology, applied in the direction of antineoplastic drugs, animal cells, vertebrate cells, etc., can solve problems such as transient effects and interference with immune tolerance

Pending Publication Date: 2020-06-26
EZY BIOTECH LLC +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0010] Each of the above approaches has its limitations: some are only effective in certain patients and only in limited types of cancer; some have short-lived effects; some treat DNA or RNA from bacteria, viruses, or retroviruses Introduce host immune cells, and some methods may indiscriminately interfere with normal immune tolerance

Method used

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  • Subject-specific tumor inhibiting cells and the use thereof
  • Subject-specific tumor inhibiting cells and the use thereof
  • Subject-specific tumor inhibiting cells and the use thereof

Examples

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Embodiment

[0205] The invention is further defined in the following examples. It should be understood, that these Examples, while indicating preferred embodiments of the invention, are given by way of illustration only. From the above discussion and these Examples, one skilled in the art can ascertain the essential characteristics of this invention, and without departing from the spirit and scope of the invention, can make various changes and modifications of the invention to adapt it to various usages and conditions.

[0206] Materials and methods

[0207] Source of T cells:

[0208] Human primary T cells were purified from the peripheral blood of healthy donors. Human TILs were isolated from fresh breast tumor samples according to approved procedures and protocols.

[0209] Isolation of T cells from blood:

[0210] From each healthy donor recruited at the clinical facility of the Institut de Recherche Clinique de Montreal (IRCM), approximately 40 mL of venous blood was collected...

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Abstract

This disclosure is directed to a pharmaceutical composition comprises tumor inhibiting cells (TICs) and a method for producing the TICs. The tumor inhibiting cells can be derived from immune cells including T cells, NK cells, or a combination thereof, modified to have inactivated Cbl-b gene alleles and free from Cbl-b bio-function (Cbl-bv- / - TICs). The Cbl-b- / - TICs are free from deoxyribonucleicacids exogenous to the immune cells. The immune cells can be isolated using a portable cell isolation and modification device. This disclosure is further directed to a method for treating tumorous conditions in subjects. The pharmaceutical composition can provide a subject-specific tumor treatment.

Description

technical field [0001] The present disclosure relates to a pharmaceutical composition comprising subject-specific tumor suppressor cells (TICs), and use thereof for treating one or more tumors in a subject. The present disclosure also relates to a method of generating subject-specific tumor suppressor cells (TICs) by modifying one or more genes of immune cells. Background technique [0002] Immunotherapy is a treatment for tumors that harnesses the natural ability of the host's immune system to specifically target and destroy tumor cells. However, tumor cells can sometimes escape detection and destruction by the host's immune system. Tumor cells can have a variety of mechanisms to evade the host immune system, such as expressing inhibitory molecules on the surface of tumor cells that can inactivate host immune cells or make tumor cells more difficult for the host immune system to detect. Tumor cells can also produce factors or induce surrounding cells to release substances...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12N9/22C12N5/0783C12N15/113C12N15/12G01N33/48
CPCA61P35/00C12N5/0636C12N2510/00A61K39/4644A61K2239/31A61K39/4611A61K2239/38C12N2310/20A61K45/06C12N9/22C12N15/11
Inventor 顾华岗·G·徐A·加津斯基童海骏
Owner EZY BIOTECH LLC
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