Preparation method, product and application of bio-electronic hydrogel

An electronic water and biological technology, applied in the direction of electromagnetic measuring device, electric/magnetic solid deformation measurement, using stable tension/pressure test material strength, etc., can solve the problems of poor biocompatibility and achieve excellent tensile strength , good electrical conductivity, and excellent self-healing properties

Active Publication Date: 2020-07-03
WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, as an implantable device or electronic skin, hydrogel often has some side effects due to poor biocompatibility, such as the performance of bacterial biofilm caused by immune inflammation, which are the needs of hydrogel for biological tissue materials. Solved technical problems

Method used

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  • Preparation method, product and application of bio-electronic hydrogel
  • Preparation method, product and application of bio-electronic hydrogel
  • Preparation method, product and application of bio-electronic hydrogel

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] 1) Preparation and characterization of gold nanorods

[0037] Step 1. Preparation of seed solution: mix 10mM chloroauric acid solution and 100mM dodecyltrimethylammonium bromide solution, add an equal volume of 10mM sodium borohydride, stir for 2 minutes, the solution becomes light brown Yellow, to obtain a seed solution;

[0038] Step 2. Growth process: Mix 10mM chloroauric acid solution, 100mM dodecyltrimethylammonium bromide solution and 100mM silver nitrate solution, add hydroquinone to it, and gently stir until the solution becomes Colorless, the seed solution obtained in step 1 was added, reacted for 6 hours, centrifuged, washed and concentrated to obtain a gold nanorod solution.

[0039] SEM detection of the prepared gold nanorods:

[0040] SEM images of gold nanorodsfigure 1 As shown in a), it can be seen from the figure that the gold nanorods are uniform in shape and short rod-shaped, the long axis size of the gold nanorods is 80±9.5nm, and the aspect ratio i...

Embodiment 2

[0049] The difference between this example and Example 1 is that in the preparation process of the bioelectronic hydrogel, the molar ratio of the carboxylic acid monomer and the calcium ions contained in the calcium nitrate solution in step 2 is 100:5, and gold nanometers are not added. Great. The hydrogel prepared in this example is designated as PC-5.

Embodiment 3

[0051] The difference between this example and Example 1 is that no gold nanorods are added during the preparation of the bioelectronic hydrogel. The hydrogel prepared in this example is designated as PC-10.

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Abstract

The invention discloses a preparation method, a product and application of biological electronic hydrogel. The preparation method comprises the following steps: mixing a carboxylic acid monomer, a calcium ion solution, polyvinyl alcohol, gold nano rods, distilled water and a photo initiator according to a certain ratio; and under the irradiation of ultraviolet rays, carrying out polymerization toobtain hydrogel. Ions are chelated with ions in macromolecules to construct a first crosslinking site; the gold nano rods and the polyvinyl alcohol crystalline phase construct a second crosslinking site, the mechanical property, the self-repairing property and the conductivity of the hydrogel are effectively improved, and meanwhile, a bacterial biofilm can be efficiently destroyed, so that the hydrogel can be used as an excellent mechanical soft material, a self-repairing ionic electronic skin and a biological multifunctional sensing body.

Description

technical field [0001] The invention belongs to the technical field of synthetic hydrogel, and in particular relates to a preparation method, product and application of bioelectronic hydrogel. Background technique [0002] In nature, biological tissues and organs have many amazing abilities, such as sensing environmental changes by transmitting signals through ion channels, self-cell division and differentiation to repair damaged components, and autoimmunity to clear foreign bacteria. Natural organic organs are usually soft, water-rich bodies with many functional units to maintain body movement. Biologically, they have many normal behavioral abilities, such as finger joints can bend flexibly, and the finger skin will naturally repair after being scratched. However, the traditional bionic design of these materials with similar functions has great challenges in the laboratory. [0003] Hydrogel is a type of material that exhibits functional properties similar to biological t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F261/04C08F220/06C08F2/44C08F2/48C08K7/00C08K3/08C08K3/28C08K3/16C08J3/075C08J3/28C08J3/24G01B7/16G01N3/08G01N17/00
CPCC08F261/04C08F2/44C08F2/48C08K7/00C08K3/08C08K3/28C08K3/16C08J3/075C08J3/28C08J3/24G01N3/08G01N17/004G01B7/16C08J2351/00C08K2003/0831C08K2003/287C08K2003/162C08F220/06
Inventor 钱秋萍周云龙孙雪丽袁林林
Owner WENZHOU INST UNIV OF CHINESE ACAD OF SCI
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