Identification method and device for miRNA causal regulation and control network, electronic equipment and storage medium

Abstract

The invention provides an identification method and device for a miRNA causal regulation and control network, belonging to the technical field of gene identification. The identification method for themiRNA causal regulation and control network comprises the following steps: acquiring a miRNA single-cell transcriptome matrix and a target gene single-cell transcriptome matrix of a given matching sample; acquiring a miRNA causal regulation and control network of the miRNA single-cell transcriptome matrix and the target gene single-cell transcriptome matrix; removing the i single cell in themiRNA single-cell transcriptome matrix and the target gene single-cell transcriptome matrix, and acquiring a miRNA causal regulation and control network after the i single cell is removed; and determining the miRNA causal control network of the i single cell according to the miRNA causal control network and the miRNA causal control network after the i single cell is removed. Because the heterogeneity of each single cell is taken into consideration, the single-cell miRNA causal regulation and control network is identified at a single-cell level, and the effect of a real miRNA causalregulation and control mechanism is reflected.

Description

technical field [0001] The present invention relates to the technical field of gene identification, in particular to a miRNA causal regulation network identification method, device, electronic equipment and storage medium. Background technique [0002] Micro Ribonucleic Acid (miRNA) is a kind of non-coding small ribonucleic acid (Ribonucleic Acid, RNA) molecule. At the post-transcriptional level, miRNA can regulate protein-coding messenger RNA (Messenger RNA, mRNA), and participate in many important cellular biological processes such as cell metabolism, cell differentiation, cell proliferation, cell growth, cell migration, cell apoptosis, and cell cycle. Therefore, the misregulation of miRNAs will lead to the disturbance of cellular biological processes, and eventually lead to many complex human diseases including cancer. [0003] In the prior art, the application scheme with the application number CN201910751340.0 provides a single-cell miRNA regulatory network identificat...

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Problems solved by technology

[0004] However, this method can only identify the correlation or association network between miRNAs and target genes at the single-cell level. In the cellular network, there is often a causal relationship between miRNAs and target genes. Correlation or association networks cannot accurately describe the regulatory network of miRNAs at the single-cell level, and cannot reflect the real causal regulation mechanism of miRNAs

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