miRNA causal regulation network identification method, device, electronic equipment and storage medium

Abstract

The invention provides a miRNA causal regulation network identification method and device, and relates to the technical field of gene identification. The miRNA causal regulatory network identification method includes: obtaining a miRNA single-cell transcriptome matrix and a target gene single-cell transcriptome matrix of a given matched sample. Obtain the miRNA causal regulatory network of miRNA single-cell transcriptome matrix and target gene single-cell transcriptome matrix. The i-th single cell in the miRNA single-cell transcriptome matrix and the target gene single-cell transcriptome matrix was eliminated to obtain the miRNA causal regulatory network after the i-th single cell was eliminated. According to the miRNA causal regulatory network and the miRNA causal regulatory network after removing the i-th single cell, the miRNA causal regulatory network of the i-th single cell was determined. Since the heterogeneity of each single cell is considered, the single-cell miRNA causal regulatory network is identified at the single-cell level, reflecting the effect of the real miRNA causal regulatory mechanism.

Description

technical field [0001] The present invention relates to the technical field of gene identification, in particular to a miRNA causal regulation network identification method, device, electronic equipment and storage medium. Background technique [0002] Micro Ribonucleic Acid (miRNA) is a kind of non-coding small ribonucleic acid (Ribonucleic Acid, RNA) molecule. At the post-transcriptional level, miRNA can regulate protein-coding messenger RNA (Messenger RNA, mRNA), and participate in many important cellular biological processes such as cell metabolism, cell differentiation, cell proliferation, cell growth, cell migration, cell apoptosis, and cell cycle. Therefore, the misregulation of miRNAs will lead to the disturbance of cellular biological processes, and eventually lead to many complex human diseases including cancer. [0003] In the prior art, the application scheme with the application number CN201910751340.0 provides a single-cell miRNA regulatory network identificat...

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Problems solved by technology

[0004] However, this method can only identify the correlation or association network between miRNAs and target genes at the single-cell level. In the cellular network, there is often a causal relationship between miRNAs and target genes. Correlation or association networks cannot accurately describe the regulatory network of miRNAs at the single-cell level, and cannot reflect the real causal regulation mechanism of miRNAs

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