Construction and detection method of calibration model for determining content of effective components in compound liquorice tablet
A technology of compound licorice tablets and active ingredients, which is applied in measuring devices, analyzing materials, and analyzing materials through optical means, and can solve problems such as weak absorption intensity, low spectral signal-to-noise ratio, and difficult quantitative analysis of NIR spectra
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Embodiment 1
[0032] The assay method of glycyrrhizic acid content in embodiment 1, compound licorice tablet
[0033] The present embodiment provides a kind of assay method of glycyrrhizic acid content in compound licorice tablet, comprises the steps:
[0034] (1) Calibration set and raw spectral data acquisition
[0035] A total of 80 batches were collected from compound licorice tablets, 60 batches were selected as the calibration set, and 20 batches were selected as the verification set. The samples were crushed through a 60-mesh sieve and dried in an oven at 70°C for 3 hours.
[0036] Utilize the near-infrared spectrometer to collect the original spectral data of the calibration set to obtain the original near-infrared spectral data of Compound Licorice Tablets, see figure 1 .
[0037] Near-infrared spectrometer: Antaris II FT-NIR Analyzer Thermo Fisher Scientific Corporation, the United States, light source; tungsten-halogen lamp, detector: InGaAs, integrating sphere diffuse reflec...
Embodiment 2、 Embodiment 1
[0066] The applicability verification of constructing correction model in the method of embodiment 2, embodiment 1
[0067] This embodiment is to verify the applicability of the calibration model constructed in embodiment 1. The difference between this embodiment and embodiment 1 is mainly that the object of content determination in step (5) is licorice extract. Specifically, step (5) of this embodiment includes:
[0068] Utilize the NIR instrument to collect the original spectral data of the licorice extract sample, input it into the TQ quantitative analysis software that has been imported into the calibration model, and obtain the content of glycyrrhizic acid in the licorice extract through software calculation, that is, the predicted value; Octadecylsilane bonded silica gel is used as filler, acetonitrile is used as mobile phase A, and 0.05% phosphoric acid solution is used as mobile phase B for gradient elution. The content determination method under the licorice extrac...
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