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Composite bone cement and preparation method and application thereof

A technology of bone cement and sodium alginate, applied in chemical instruments and methods, phosphorus compounds, pharmaceutical formulations, etc., can solve problems such as poor injectability and easy collapse, and achieve the goals of inhibiting collapse, promoting bone regeneration, and excellent collapse resistance Effect

Pending Publication Date: 2020-07-10
上海亚朋生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] For this reason, the embodiment of the present invention provides a composite bone cement and its preparation method and application to solve the problems of poor injectability or easy collapse of the existing hydroxyapatite bone cement.

Method used

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  • Composite bone cement and preparation method and application thereof
  • Composite bone cement and preparation method and application thereof
  • Composite bone cement and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] The preparation method of the composite bone cement of this embodiment:

[0029] (1) Preparation of sodium alginate solution: Weigh 5g of sodium alginate powder with a molecular weight of 5000 to 200000 and add it to 100 mL of deionized water, and stir at room temperature for 4 hours to obtain sodium alginate with a concentration of 4.76% by mass Store the solution in a refrigerator at 4°C for later use;

[0030] (2) Hydroxyapatite and sodium alginate solution were mixed according to a weight ratio of 1.6:1, and stirred at room temperature for 3 minutes to obtain a paste composite bone cement.

Embodiment 2

[0032] The preparation method of the composite bone cement of this embodiment:

[0033] (1) Preparation of sodium alginate solution: Weigh 2g of sodium alginate powder with a molecular weight of 5000~200,000, add it to 100mL of deionized water, and stir it evenly for 2h at room temperature to obtain a mass percentage concentration of 1.96% Sodium alginate solution should be stored in a refrigerator at 4℃ for later use;

[0034] (2) Hydroxyapatite and sodium alginate solution are mixed according to a weight ratio of 1.45:1, and stirred at room temperature for 1.5 minutes to obtain a paste composite bone cement.

Embodiment 3

[0036] The preparation method of the composite bone cement of this embodiment:

[0037] (1) Preparation of sodium alginate solution: Weigh 3g of sodium alginate powder with a molecular weight of 5000~200,000 and add it to 100mL of deionized water, and stir it evenly for 2.5 hours at room temperature to obtain seaweed with a mass percentage concentration of 2.91% Sodium solution, store in a refrigerator at 4°C for later use;

[0038] (2) Hydroxyapatite and sodium alginate solution were mixed according to a weight ratio of 1.45:1, and stirred at room temperature for 1.5 minutes to obtain a paste composite bone cement.

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Abstract

The invention discloses a composite bone cement and a preparation method and application thereof, and belongs to the technical field of biomedical materials. The composite bone cement is formed by compounding a solid phase and a liquid phase according to a weight ratio of 0.8-2.8: 1, wherein the solid phase is hydroxyapatite, and the liquid phase is a sodium alginate solution. According to the composite bone cement, hydroxyapatite and sodium alginate are used as raw materials, calcium ions dissolved out of the hydroxyapatite and the sodium alginate generate calcium alginate hydrogel, and the calcium alginate hydrogel can be automatically solidified, effectively inhibit collapse of bone cement, and has excellent resistance to collapse, injectability and plasticity. In addition, the composite bone cement has excellent biocompatibility, can support adhesion, proliferation and differentiation of related osteoblasts, and has important application value in the aspects of promoting bone regeneration and treating bone defects. The preparation method is simple and operable, low in cost, and easy to realize large-scale production.

Description

Technical field [0001] The embodiment of the present invention relates to the technical field of biomedical materials, in particular to a composite bone cement and a preparation method and application thereof. Background technique [0002] Bone defect is the most common disease in orthopedics and requires a lot of bone repair materials to cure and repair. Therefore, the development of various biomedical materials suitable for human bone defect repair has important social significance. In the field of inorganic bone repair materials, compared with bulk bioceramic materials, self-curing materials have the unique properties of low-temperature curing, injectable, and arbitrarily shaping according to the shape of the bone defect (Journal of the Ceramic Society of Japan 1991; 99:954-64) has received widespread attention and applications. [0003] Hydroxyapatite (Hydroxyapatite) referred to as HA or HAP, chemical formula: Ca 10 (PO 4 ) 6 (OH) 2 , Is the main inorganic component in the hu...

Claims

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Application Information

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IPC IPC(8): A61L27/12A61L27/50A61L27/20A61L27/54C01B25/32B82Y40/00
CPCA61L27/12A61L27/20A61L27/50A61L27/54A61L2300/112A61L2300/412A61L2400/06A61L2430/02B82Y40/00C01B25/32C01B25/321C01P2004/10C01P2004/16C01P2004/62C01P2004/64C08L5/04
Inventor 李淼白玉龙陈金发周小垚
Owner 上海亚朋生物技术有限公司
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