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Camellia nitidissima theaflavin medicament for resisting novel coronavirus and preparation method and application thereof

A coronavirus, golden camellia technology, applied in the field of medicine, to achieve the effect of improving the inhibition rate, protecting the skin and eliminating inflammation

Pending Publication Date: 2020-07-14
SHAOGUAN COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, there is currently no report on the application of theaflavins in Camellia japonica for the prevention and treatment of new coronaviruses.

Method used

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  • Camellia nitidissima theaflavin medicament for resisting novel coronavirus and preparation method and application thereof
  • Camellia nitidissima theaflavin medicament for resisting novel coronavirus and preparation method and application thereof

Examples

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preparation example Construction

[0027] Based on the above formula, the present invention also provides a method for preparing an anti-new coronavirus chrysanthemum tea theaflavin medicament, comprising the following steps:

[0028] (1) Camellia pretreatment: select leaves or petals of Camellia camellia, wash, dry, crush, and sieve to obtain Camellia camellia tea powder; the Camellia nitidissima Chi ), Camellia tunghinensis H.T.Chang, Camellia pubipetala Y.Wanet S.Z.Huang, Camellia impressinervis Chang et S.Y.Liang, Camellia multipetala Liang et Any one or a combination of Deng var. patens (Liang et Mo) S.Y. Liang), Camellia euphlebia Merr.ex Sealy and Camellia longruiensis S.Y.Liang et X.J.Deng. Weigh 1-30g of the Camellia japonica tea powder, add anhydrous ethyl acetate for extraction at a solid-to-liquid ratio of 1 / 20-30 and obtain an extract, remove the ethyl acetate by evaporation, and then use 1 / 3 of the volume of the extract in chloroform The extracted product is washed three times respectively, and t...

Embodiment 1

[0037] (1) Golden camellia pretreatment: select the leaves or petals of golden camellia, optimize according to "Chinese Pharmacopoeia" (2015), then wash, dry and pulverize into powder, sieve with a 20-mesh sieve to obtain golden flowers after sieving Tea tea powder; the golden camellia is Dongxing golden camellia (Camellia tunghinensis H.T.Chang). Weigh 2.0 g of Camellia japonica tea powder from step (1), add 40 mL of anhydrous ethyl acetate for extraction, filter after the extraction is complete, wash the filter residue three times with 10 mL of ethyl acetate, combine the extracts, and remove the acetic acid by rotary evaporation ethyl ester, and then wash the extracted product with 13ml of chloroform, wash three times respectively, and vacuum-dry the obtained solid at 60°C to obtain the ethyl acetate extract of Camellia japonica, which is the crude product of camellia japonica theaflavins.

[0038] (2) extracting Camellia theaflavin-3-mono-gallate and Camellia theaflavin-3,3...

Embodiment 2

[0044] (1) Golden camellia pretreatment: select the leaves or petals of golden camellia, optimize according to "Chinese Pharmacopoeia" (2015), then wash, dry and pulverize into powder, sieve with a 30-mesh sieve to obtain golden flowers after sieving Tea tea powder; the golden camellia is Camellia longruiensis S.Y.Liang et X.J.Deng. Weigh 3.0 g of Camellia japonica tea powder, add 65 mL of anhydrous ethyl acetate for extraction, filter after extraction, wash the filter residue three times with 12 mL of ethyl acetate, combine the extracts, remove ethyl acetate by rotary evaporation, and then use The extracted product was washed with 22 ml of chloroform and washed three times respectively, and the obtained solid was vacuum-dried at 60° C. to obtain the ethyl acetate extract of Camellia japonica, which is the crude product of Camellia japonica theaflavins.

[0045] (2) extracting Camellia theaflavin-3-mono-gallate and Camellia theaflavin-3,3'-bis-gallate respectively, wherein,

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Abstract

The invention provides a camellia nitidissima theaflavin medicament for resisting novel coronavirus. The formula comprises the following raw materials in parts by mass: 20-60 parts of camellia nitidissima theaflavin-3-monogallate, 20-60 parts of camellia nitidissima theaflavin-3, 3'-digallate, 3-8 parts of hyaluronic acid, 8-20 parts of nicotinamide, 15-30 parts of ceramide, 3-10 parts of pyruvicacid, 12-30 parts of sodium pyruvate, 3-8 parts of polyhexamethylene guanidine, 5-15 parts of Tween, 150-500 parts of glycerol and 15-35 parts of paraben. Compared with the prior art, camellia nitidissima theaflavin-3-monogallate and camellia nitidissima theaflavin-3, 3'-digallate are mixed uniformly; and 3, 3'-digallate is used as a main active component, the activity of reverse transcriptase ofRNA viruses can be effectively inhibited, then the purpose of killing novel coronaviruses is achieved, hyaluronic acid, nicotinamide, ceramide, glycerol and other components are further matched, the nourishing and fine line removing effects are remarkable, and the medicament is very suitable for being applied to the surface of human skin.

Description

technical field [0001] The present invention relates to the technical field of medicine, in particular to a golden camellia theaflavin medicament against novel coronavirus and its preparation method and application. Background technique [0002] Camellia nitidissima C.W.Chi belongs to the family Theaceae and Camellia genus. According to the inspection by the Institute of Nutrition and Food Safety, China Center for Disease Control and Prevention, Camellia nitidissima C.W.Chi is non-toxic and contains a variety of nutrients such as theaflavins, tea polysaccharides, Tea polyphenols, total flavonoids, etc. have very high medicinal value. Especially the theaflavins, which are rich in Camellia Camellia, account for 1-5% of the solids of Camellia Camellia. Theaflavins belong to plant phenolic pigments. Theaflavins include four main components, namely theaflavins (TF ), theaflavin-3-gallate (TF-3-G), theaflavin-3 ’ - Gallate (TF-3 ’ -G) and theaflavin digallate (TFDG). Studies h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A01N47/44A01N43/16A01P1/00A61K31/353A61K31/785A61P31/14
CPCA01N47/44A01N43/16A61K31/353A61K31/785A61P31/14A61K2300/00A61K31/455A61K31/047A01P1/00A61K36/82A61K2236/00A61K9/0078A61P31/16
Inventor 程金生万维宏
Owner SHAOGUAN COLLEGE
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