A kind of polyacrylamide hydrogel dressing and preparation method and application thereof
The technology of polyacrylamide and hydrogel dressings is applied in bandages, medical science and other directions, can solve the problems of difficult application of wound dressings, large molecular weight of curcumin, low bioavailability, etc., achieves good moisturizing and air permeability, and has a simple preparation method. , the effect of accelerating epithelial regeneration
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Embodiment 1
[0069] (1) In parts by weight, 100 parts of acrylamide and 0.06 parts of cross-linking agent N,N′-methylenebisacrylamide were dissolved in 264 parts of deionized water by magnetic stirring in an ice bath at 3°C to obtain a homogeneous aqueous solution;
[0070] (2) In parts by weight, add 0.44 parts of curcumin to 36 parts of polypropylene glycol 1, ultrasonically disperse at 25°C until the curcumin is fully dissolved, and the ultrasonic frequency is 40KHz to obtain a curcumin polypropylene glycol solution;
[0071] (3) Add the curcumin polypropylene glycol solution in step (2) to the homogeneous aqueous solution in step (1), and magnetically stir for 2 hours in an ice bath at 3°C to form a uniformly dispersed emulsion; pass nitrogen flow through the emulsion for 30s to exclude oxygen Finally, add 0.18 parts of ammonium persulfate and 0.12 parts of N,N,N',N'-tetramethylethylenediamine successively, and keep stirring for 20 minutes under the condition of ice bath at 3°C t...
Embodiment 2
[0073] (1) In parts by weight, 100 parts of acrylamide and 0.24 parts of cross-linking agent N,N′-methylenebisacrylamide were dissolved in 278 parts of deionized water by magnetic stirring in an ice bath at 3°C to obtain a homogeneous aqueous solution;
[0074] (2) In parts by weight, add 0.30 parts of curcumin to 22 parts of polypropylene glycol 1, ultrasonically disperse at 25°C until the curcumin is fully dissolved, and the ultrasonic frequency is 40KHz to obtain a curcumin polypropylene glycol solution;
[0075] (3) Add the curcumin polypropylene glycol solution in step (2) to the homogeneous aqueous solution in step (1), and magnetically stir for 1 hour in an ice bath at 3°C to form a uniformly dispersed emulsion; pass a nitrogen stream through the emulsion for 30 seconds to exclude oxygen Finally, add 0.27 parts of ammonium persulfate and 0.18 parts of N,N,N',N'-tetramethylethylenediamine successively, and keep stirring for 20 minutes under the condition of ice bath ...
Embodiment 3
[0077] (1) In parts by weight, 100 parts of acrylamide and 0.48 parts of cross-linking agent N,N′-methylenebisacrylamide were dissolved in 242 parts of deionized water by magnetic stirring in an ice bath at 3°C to obtain a homogeneous aqueous solution;
[0078] (2) In parts by weight, add 0.38 parts of curcumin to 58 parts of polypropylene glycol 2, ultrasonically disperse at 25°C until the curcumin is fully dissolved, and the ultrasonic frequency is 40KHz to obtain a curcumin polypropylene glycol solution;
[0079] (3) Add the curcumin polypropylene glycol solution in step (2) to the homogeneous aqueous solution in step (1), and magnetically stir for 1.5 hours in an ice bath at 3°C to form a uniformly dispersed emulsion; pass nitrogen flow through the emulsion for 30 seconds to remove After oxygen, add 0.4 parts of ammonium persulfate and 0.24 parts of N,N,N',N'-tetramethylethylenediamine successively, and keep stirring for 10 minutes in an ice bath at 3°C to make the m...
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