Microbial flora marker for evaluating chemotherapy curative effect of pancreatic cancer and application of microbial flora marker

A technology of microbial flora and markers, applied in the field of medical detection, can solve the problems of biological complexity and precise treatment obstacles, and the incomplete understanding of microorganism-host-drug interactions, etc., to achieve practical clinical application, good usability, and sensitivity high effect

Active Publication Date: 2020-07-28
SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

[0005] Although some progress has been made in this field of pancreatic cancer, microbe-host-drug interactions are still poorly understood, biological complexity remains a huge obstacle to precision therapy, and more research is needed to understand the microbiota. The role of group in the chemoresistance of pancreatic cancer

Method used

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  • Microbial flora marker for evaluating chemotherapy curative effect of pancreatic cancer and application of microbial flora marker
  • Microbial flora marker for evaluating chemotherapy curative effect of pancreatic cancer and application of microbial flora marker
  • Microbial flora marker for evaluating chemotherapy curative effect of pancreatic cancer and application of microbial flora marker

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Embodiment 1

[0044] 1.1 Inclusion of clinical samples and treatment plan

[0045] A total of 63 patients with pancreatic cancer were selected from Shandong Cancer Hospital from August 2017 to February 2019, and all patients were confirmed by examination (examination and diagnosis methods B-ultrasound, CT, etc.). The age range of included patients was 32-73 years old, including 39 male patients and 24 female patients.

[0046] Chemotherapy regimen for patients: monotherapy for patients: GEM (gemcitabine) 1000mg / m 2 , intravenous infusion for 30 minutes; combined use: GEM 1000mg / m 2 Give 5-Fu (5-fluorouracil) 600 mg / m after intravenous infusion for 30 minutes 2 , intravenous infusion; all patients were administered at intervals of 7 days, and every 28 days was considered as a treatment cycle, and the clinical chemotherapy effect was evaluated for 2 consecutive cycles.

[0047] Chemotherapy efficacy criteria: complete remission: the tumor disappears and lasts for >1 month; partial remissio...

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Abstract

The invention discloses a microbial flora marker for evaluating the chemotherapy curative effect of pancreatic cancer and an application of the microbial flora marker, belongs to the technical field of medical detection. By obtaining the relative abundance content of the microbial marker and giving a prediction probability through model calculation, the microbial flora marker can be used for assisting in evaluating the chemotherapy curative effect of pancreatic cancer, reducing an improper chemotherapy cycle and buying time for effective treatment of a patient.

Description

technical field [0001] The invention belongs to the technical field of medical detection, and relates to the direction of tumor detection based on intestinal microbial flora, and specifically relates to a microbial flora marker for evaluating the curative effect of pancreatic cancer chemotherapy and its application. Background technique [0002] In recent years, with the progress of biological research, more and more studies have shown that the microbial flora in the human body, especially the intestinal microbial flora, is closely related to various diseases of the human body, including heart disease. Cerebrovascular disease, rheumatoid arthritis, diabetes, obesity and tumors. In the study of the relationship between gut microbiota and tumors, researchers have gradually discovered that gut microbiota plays an important role in the occurrence, development and treatment of liver cancer, pancreatic cancer, melanoma, blood system tumors, breast cancer and other tumors. importa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/689C12Q1/04C12Q1/6886C12Q1/6869C12Q1/6851
CPCC12Q1/6851C12Q1/6869C12Q1/6886C12Q1/689C12Q2600/158
Inventor 姜书梅司峻岭刘天行岳金波王仁本
Owner SHANDONG RES INST OF TUMOUR PREVENTION TREATMENT
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