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Complex of lactoferrin and silica, process for preparing and compositions for oral hygiene

A technology of silicon dioxide and lactoferrin, applied in the field of oral hygiene compositions, can solve the problems of oxidative degradation, poor compatibility, low bioavailability and the like

Inactive Publication Date: 2020-07-31
L I 瑞思有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] The use of lactoferrin in the field of oral care products is currently not widely used, mainly because of its poor stability and compatibility with excipients commonly used in oral care products, such as toothpaste, gel or mouthwash. poor tolerance
Lactoferrin also has relatively low bioavailability when applied topically and is prone to oxidative degradation

Method used

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  • Complex of lactoferrin and silica, process for preparing and compositions for oral hygiene
  • Complex of lactoferrin and silica, process for preparing and compositions for oral hygiene
  • Complex of lactoferrin and silica, process for preparing and compositions for oral hygiene

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1-3

[0052] Preparation of the composition shown in Table 1 (% by weight of the total composition):

[0053] Table 1

[0054]

[0055]

[0056] (*)Compare

[0057] Hydrophilic silica: The specific surface area is about 200m 2 / g (BET area, measured according to standard ISO 9277-2010) of hydrophilic fumed silica (commercial product Aerosil TM 200 from Evonik);

[0058] Rice husk silica: The specific surface area is about 550m 2 / g (BET area, measured according to standard ISO 9277-2010) and a density of about 0.050 g / cm 3 Silica in the form of an aerogel.

[0059] Rice husk silica and lactoferrin are compounded in advance by the following method. The preparation of rice husk silica was as described in Example 1 of WO2016 / 193877, except that, after obtaining the silica sol-gel, it was added to lactoferrin, and then as in the same Example 1 The supercritical CO 2 Drying, with the difference that the silica sol-gel with added lactoferrin is treated in an autoclave at a te...

Embodiment 4-6

[0086] Examples 2 and 3 were repeated under the same conditions with the same ingredients as described above (Examples 4 and 5). Another comparative example (Example 6) was carried out again with the same procedure and the same ingredients, in which lactoferrin was simply mixed with hydrophilic silica, i.e. no complex according to the invention was prepared, in which the silica Prepared in sol-gel form, with lactoferrin added, then dried. Compositions are reported in Table 4 (% by weight of total composition):

[0087] Table 4

[0088] Example 4 5(*) 6(*) glycerin 51.0 74.0 51.0 water 15.0 25.0 15.0 Hydrophilic silica 30.0 -- 33.0 Rice husk silica 3.0 -- -- Lactoferrin 1.0 1.0 1.0

[0089] (*)Compare

[0090] The antioxidant and antimicrobial properties of these compositions were verified and the efficacy over time was evaluated as described in Examples 1-3.

[0091] The results are reported in the table below, where...

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Abstract

The present invention relates to a complex comprising at least one lactoferrin and at least one silica having a specific surface area comprised between 100 m2 / g and 1000 m2 / g (BET area, measured according to standard ISO 9277-2010). The complex is obtainable by adding the lactoferrin to the silica in the form of a sol-gel with an aqueous solvent, and subsequent drying of the sol-gel. The complex is particularly suitable for use in oral care products, in particular toothpastes, mouthwashes, gels, chewing gum, tablets for use in oral care, gingival dyes, and the like. The complex features a highlevel of stability and bio-availability, such that it has an effective, long-lasting antibacterial and antioxidant action within the oral cavity. The complex is particularly suitable for the prevention or treatment of diseases of dental apparatus, in particular for the prevention or treatment of periodontitis or peri- implantitis, preferably in patients suffering from diabetes.

Description

technical field [0001] The present invention relates to a complex comprising a lactoferrin and a silicon dioxide, a process for its preparation, and a composition thereof for oral hygiene, in particular in cases of increased oxidative stress in the oral cavity. Background technique [0002] It is well known that oral hygiene is a decisive factor in the prevention of diseases of the dental organs such as dental caries, gingivitis, periodontitis, peri-implantitis. [0003] Periodontitis is known to be a chronic inflammatory disease characterized by the destruction of the tooth's supporting structures (periodontal ligament, alveolar bone). Periodontitis has a high incidence in the general population (approximately 10% to 15% of adults) and has many negative effects on quality of life. [0004] Peri-implantitis, on the other hand, is an inflammatory process that affects the tissue surrounding the implant where the implant is osseointegrated, resulting in loss of bone tissue and...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/64A61K8/25A61Q11/00
CPCA61K8/25A61K8/64A61Q11/00A61K2800/56A61K2800/84C01B33/148C01B33/158C07K14/79
Inventor 亚斯纳·伊莎贝尔·西斯特纳斯·西斯特纳斯
Owner L I 瑞思有限公司
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