26 results about "Peri-implantitis" patented technology

The invention provides a peri-implantitis onset risk prediction method and system and a medium, and belongs to the technical field of auxiliary prediction models.The peri-implantitis onset risk prediction method includes the steps that metabolite components of gingival crevicular fluid samples of multiple patients are obtained, difference analysis is conducted on metabolites through an OPLS-DA analysis method, a T test method, a multiple change method and an ROC curve drawing method, and the metabolite components of the gingival crevicular fluid samples of the multiple patients are obtained; determining differential metabolites as metabolite factors; acquiring baseline level information of a plurality of patients as clinical factors; taking the screened metabolite factors and clinical factors as independent variables, forming a data matrix constructed by grade variables and classification variables, and constructing a training set; and constructing a random forest model, and training through the training set to obtain a prediction model for predicting the peri-implant disease. According to the method, metabolic factors and clinical factors are considered to construct a peri-implantitis onset risk prediction model, and better technical support is provided for auxiliary judgment of the peri-implantitis onset risk.

The invention discloses an antioxidant and antibacterial collagen repair membrane and a preparation method thereof. The repair membrane is prepared by sequentially carrying out polylysine graft modification and catechinic aldehyde and aminoglycoside antibiotic synchronous covalent grafting on a purified collagen membrane. By controlling parameters such as molecular weight and concentration of polylysine, proportion and loading capacity of functional molecules, reaction conditions and the like, accurate regulation and control of film thickness, function release rate, oxidation resistance and antibacterial performance can be realized. The invention further provides a double-layer composite membrane structure, the rapid antibacterial layer and the long-acting anti-oxidation layer are compounded, and function decoupling and time sequence collaboration are achieved. The repair membrane has excellent oxidation resistance and broad-spectrum antibacterial performance, is good in biocompatibility and adjustable in degradation rate, can be customized according to different clinical requirements, and is suitable for oral wound repair, periodontal guided tissue regeneration, bone tissue induced regeneration, peri-implantitis prevention and treatment and chronic refractory wound treatment.

The invention provides a photosensitizer / ZIF-8 nanocomposite, a preparation method and application thereof, and a pharmaceutical composition for treating periodontitis and / or peri-implantitis. The photosensitizer / ZIF-8 nano-composite is prepared by the preparation method disclosed by the invention. The preparation method comprises the following steps: dissolving zinc salt in a solvent to form a solution A; dissolving an imidazole ligand in a solvent, and adding a photosensitizer under a dark condition to form a solution B; quickly adding the solution A into the solution B under a dark condition, and stirring and reacting at room temperature; and after the reaction is completed, centrifugally separating to obtain a solid product, washing and drying. The application of the photosensitizer / ZIF-8 nano-composite comprises the application of the photosensitizer / ZIF-8 nano-composite in preparation of photodynamic antibacterial drugs. A pharmaceutical composition for treating periodontitis and / or peri-implantitis comprises the photosensitizer / ZIF-8 nano compound and an auxiliary material. The preparation method is simple, the raw materials are cheap and easy to obtain, and the obtained compound serving as the photodynamic antibacterial agent is remarkable in antibacterial effect and low in toxicity.

An intraoral device 16 for treatment of peri-implantitis has a head 20 that supports an optical engine 22. The optical engine comprises an enclosure for accommodating a dental implant in vivo and ligh

Compositions containing a polyphosphate and an amino acid N,N-diacetic acid, formulated as either liquid compositions that upon warming to body temperature solidify into a viscous gel, or solid dosage forms, which are useful as dental compositions for removing microbial biofilm, or inhibiting or disrupting formation thereof. A method for removing microbial biofilm from, or inhibiting or disrupting microbial biofilm formation in, a periodontal pocket, gingival pocket, pocket resulting from peri-implantitis, or caries associated with dental cavities or the root canal system, including administering the compositions.

The invention discloses an implant system capable of treating peri-implantitis, and belongs to the field of dental restoration materials. Comprising an implant body, the upper section of the implant body is a neck area, and the neck area is provided with an external connecting structure matched with a neck ring; the implant body realizes complete osseointegration with an alveolar bone after being implanted, and a part exposed to a soft tissue interface does not exist; the replaceable neck ring accessory comprises a series of neck rings with different heights and smooth outer surfaces, and the replaceable neck ring accessory is used for being mounted in the neck area of the implant body when peri-implantitis occurs; the roughness of the outer surface is Raut; and 0.2 [mu] m. After the peri-implantitis occurs, the smooth neck ring is replaced or screwed in, the rough surface of the neck is quickly changed into a smooth surface, and an interface which is not beneficial to plaque adhesion is formed, so that the microenvironment around the implant is improved, auxiliary treatment and control of occurrence and development of the peri-implantitis are realized, the structure is adjustable, the use is flexible, and the operation is convenient.

An intraoral device for treatment of peri-implantitis has a head that supports an optical engine. The optical engine comprises an enclosure for accommodating a dental implant in vivo and light emitters such as LED arrays or waveguides angularly spaced around the enclosure, configured to emit UVC light into the enclosure. One or more jaws are movable to open and close the enclosure. At least one of the light emitters is mounted on the or each jaw and at least one of the light emitters is fixed relative to a housing that supports the or each jaw. High-wavelength light sources and low-wavelength light sources are employed for photo-functionalisation of the implant and / or for sterilisation of the implant region. At least one supplementary array on an edge or end of the enclosure comprises additional low-wavelength light sources and emits light away from the enclosure for sterilisation of the implant region.

The application discloses a kind of implant piezoelectric nano coating and its preparation method and application.The nano coating is composed of nano-flower-shaped barium titanate and gold nanoparticles loaded on its surface.In this application, gold nanoparticles are deposited on nano-barium titanate at high temperature by using the method of sodium citrate reducing tetrachloroauric acid. The nBTO@Au prepared by this method has obvious osteogenesis and antibacterial properties. The application provides a high reactivity, catalytic and non-invasive immediate treatment mode for peri-implantitis, which has wide application potential in implant post-disinfection, peri-implantitis treatment and improving implant survival rate.

The present invention provides an in situ gene transfection system based on a hydrogenated TiO2 nanotube composite coating, as well as its construction method and application. The in situ gene transfection system uses hydrogenated TiO2 nanotubes as a substrate and utilizes a layer-by-layer self-assembly technique to prepare a dopamine / graphene oxide / type IV collagen composite coating. This system can enhance the surface bioactivity of biomedical metal materials while also serving as an in situ gene transfection system for substrate-mediated local viral delivery, improving gene transfection efficiency and treatment safety, and enabling precise regulation of the treatment site. The in situ gene transfection system provides a new strategy for enhancing peri-implant epithelial sealing and preventing peri-implantitis.

The application relates to the technical field of dental implants, in particular to a trans-zygomatic implant and a processing technology thereof, and the processing technology comprises variable-distance multi-stage sand blasting and acid etching surface treatment on an anchoring part with threads of the trans-zygomatic implant and electrochemical polishing surface treatment on an extension part without threads. The trans-zygomatic implant is treated by variable-distance multi-stage sand blasting combined with acid etching, so that a uniform micron-level rough base and a multi-stage micropore structure can be formed on the titanium surface, osteoblast adhesion and differentiation are facilitated, the early bone combination speed is accelerated, the combination strength is improved, the early implant loosening risk is reduced, the extension part of the trans-zygomatic implant is treated by electrochemical polishing, a smooth surface can be obtained, plaque adhesion and bacterial colonization are greatly reduced, the implant peri-implantitis risk is reduced, and soft tissue adhesion is promoted; the dual optimization of bone anchoring and tissue adhesion is realized, and the long-term function and health of the trans-zygomatic implant under complex stress are guaranteed.

The peri-implantitis treatment device (1) according to the present invention is provided with: an electrode (14) for applying a negative potential to a metal part (7) of a dental implant (8); a potential controller for controlling the potential of the electrode (14); and a mouthpiece (2) that holds the electrode (14) and the potential controller and is attached to the dental implant (8). The peri-implantitis treatment device (1) according to the present invention can effectively inactivate even bacteria (bacterial colonies) that are in a deep periodontal pocket hardly cleaned mechanically and in a state of forming a biofilm against which antibiotics are less effective.

The invention discloses an implant piezoelectric nano coating as well as a preparation method and application thereof. The nanometer coating is composed of nanometer flower-shaped barium titanate and gold nanoparticles loaded on the surface of the nanometer flower-shaped barium titanate. According to the invention, gold nanoparticles are deposited on nano barium titanate at a high temperature by using a method of reducing tetrachloroauric acid by using sodium citrate, and nBTOatAu prepared by using the method has obvious osteogenesis and antibacterial properties. The invention provides a high-reactivity, catalytic and non-invasive immediate treatment mode for the peri-implantitis, and has wide application potential in the aspects of post-implant disinfection, peri-implantitis treatment and implant survival rate improvement.

The present invention provides a detachable soft tissue-level implant and a dental implant system having the same. The detachable soft tissue-level implant includes an implant body and a gingiva-penetrating collar. The implant body includes a bone-penetrating portion buried in the alveolar bone. A gingiva-penetrating portion extending proximally is provided on the proximal end face of the bone-penetrating portion, and the gingiva-penetrating portion is buried in the gingival soft tissue. The gingiva-penetrating collar is a hollow structure and is detachably sleeved at a fixed position on the outer wall of the gingiva-penetrating portion. By designing the soft tissue-level implant as a split structure of a detachable implant body and a gingiva-penetrating collar, the problem of inconvenient clearance of inflammation around the implant in clinical practice is solved.

The invention discloses a PEEK-Zr / ZrO2-FeNC surface modified material as well as a preparation method and application thereof. The surface modified material comprises a PEEK base material, Zr / ZrO2 deposited on the surface of the PEEK base material, and FeNC nano-enzyme particles uniformly distributed on the surface of the PEEK base material subjected to Zr / ZrO2 deposition. According to the invention, Zr / ZrO2 is deposited on the surface of the PEEK base material, so that the formation of a biological membrane on the surface of the material can be reduced, and the risk of occurrence of peri-implantitis is reduced; in addition, the introduction of zirconium can increase the toughness of the special appearance of the PEEK surface, and reduce the surface damage when the implant material is beaten; the FeNC nano-enzyme particles incarcerated in the Zr / ZrO2 layer can remove ROS in the early stage of osseointegration, macrophages are polarized to an M2 type, an anti-inflammatory microenvironment is formed, finally, adhesion of osteoblasts is enhanced by using a zirconium oxide columnar structure, and the cells are anchored on the surface of PEEK to promote osseointegration.

The invention belongs to the technical field of medical instruments, and particularly relates to an individual tooth and dentition periodontal state in-situ detection system based on an intelligent tooth socket, the detection system comprises a tooth socket body, the tooth socket body is a customized double-layer tooth socket based on human dentition form digital modeling, the tooth socket is characterized in that the micro-detection sensitive periodontal sensor is directly integrated in the inner layer of the tooth socket body, the micro-fluidic chip is mounted in the hollow part of the tooth socket body, the micro-fluidic chip and the micro-detection sensitive periodontal sensor are connected through the capillary channel, and gingival sulcus liquid is transmitted by the capillary channel and is transported to the micro-detection sensitive periodontal sensor. According to the invention, the periodontal sensor and the tooth socket are integrated, the periodontal state of individual teeth and dentition can be accurately detected according to the personalized design of the tooth socket, and the micro-fluidic equipment is used for pump-free self-driven transmission of multi-tooth gingival crevicular fluid and the electrochemical sensor is used for detecting periodontal related biomarkers. The device can be used for diagnosis grading of periodontitis and peri-implantitis, reconstruction monitoring of periodontal tissue in the orthodontic treatment process and periodontal health monitoring, and the problems that at present, a gingival crevicular fluid in-situ detection device is lacked, and the periodontal state of each tooth position is difficult to determine are solved.

Disclosed are a multi-point fixation two-piece root analogue implant apparatus and use thereof, which relate to the technical field of human stomatology. The apparatus comprises a root analogue implant, a transgingival collar, a fixation screw, a healing screw, a restoration screw, and a restoration abutment, wherein the root analogue implant is internally provided with a restoration fixation channel and 1-3 fixation screw channels, and all the channels are internally threaded. The occlusal surface of the upper end of the implant is provided with a fixation recess. The restoration abutment is internally provided with a V-shaped channel, and the smaller opening of the channel corresponds to the restoration fixation channel on the gingival surface of the implant. The gingival surface of the restoration abutment is provided with a fixation protrusion matched with the fixation recess. The transgingival collar is 3D printed by using zirconia and is used after the tissue surface is glazed. This solves the problem of unsightly blackening of the gums due to metal ion precipitation and oxidation at the metal transgingival portion. Furthermore, the smooth glazed surface resists bacterial adhesion, effectively preventing peri-implantitis. The technical solutions of the present invention can improve the initial stability of RAI implantation and expand the clinical indications for RAI.

An antibacterial alloy material suitable for making biomedical implants and surgical instruments and devices associated with biomedical implantation is disclosed. The alloy material comprises about 50–99.99 wt.% Ti, about 1–49 wt.% Cu, and about 0.01–10 wt.% SiO2. The antibacterial alloy material imparts antibacterial properties by enabling controlled ion release to inhibit biofilm formation, addressing issues like peri-implantitis associated with conventional bio-inert materials. In addition, the antibacterial alloy material enhances osseointegration and improves the mechanical durability of the resulting implants and surgical instruments and devices, including hardness and wear resistance. In addition, the antibacterial alloy material exhibits anti-corrosive properties and may be fabricated via techniques like spark plasma sintering (SPS).

The invention discloses a method for evaluating oral implant position points and peri-implantitis by applying near-infrared transmission and reflection mode fusion imaging, an imaging system and a storage medium. The method comprises the following steps: (1) irradiating an implant with near-infrared light to obtain near-infrared image information of the implant; and (2) analyzing the near-infrared image information in the step (1) by adopting an image processing and analysis algorithm to obtain the two-dimensional geometric information and the one-dimensional depth information of the implant, and exploring the body position point of the oral implant and the bone defect around the implant according to the two-dimensional geometric information and the one-dimensional depth information of the implant. According to the image processing and analysis algorithm, key information related to oral implant position points and peri-implantitis is extracted from an imaging result, that is, a near-infrared transmission image and a reflection image are combined, and more comprehensive imaging information can be obtained.

The present disclosure provides for compositions including GlcNAc and methods of treating or preventing oral diseases, and the like. In an aspect, GlcNAc can be used as an agent in a composition to treat and / or prevent oral diseases such as dental caries (or tooth decay), oral candidiasis (or oral thrush), periodontitis, peri-mucositis and peri-implantitis. Each of these diseases is a biofilm disease with a dysbiotic etiology.

Distraction device known as an implant distractor device for distracting atrophied bone and simultaneously placing a dental implant. • The implant-distractor device is characterized by its ability to be manufactured from any biocompatible material. The implant-distractor device consists of: a) a deflectable implant: • The distractible implant is characterized by a mechanical or electronic locking system to prevent its movement after the desired distraction. • The distractible implant is characterized by sacred spaces to allow the upper part to rest in the lower part prior to distraction. • The deflectable implant is characterized by the fact that both an upper and a lower part can be provided with or without a thread to enable osseointegration. • The deflectable implant is characterized by its ability to be deflected or telescoped as needed. • The deflectable implant features different thread designs on its surface so that it can be deflected or telescoped as needed. • The deflectable implant is characterized by different thread designs on the surface to improve osseointegration, increase the surface area of ​​the implant bone or improve soft tissue healing. • The deflectable implant is characterized by its ability to support a temporary or permanent restoration to replace the missing teeth. • A device with a surface treatment to improve osseointegration or to increase the implant-bone surface area. b) a distraction activator with titanium wings: • The distraction activator is characterized by a stabilizing arm for fixation of the distracted implant. • The titanium wings of the distraction activator are characterized by triangular or circular slots to allow the placement of screws of different sizes. • The distraction activator is characterized by the fact that the stabilizing arm can be extended horizontally in order to adjust the distance between the distraction activator and the deflectable dental implant. • The distraction activator is characterized by the fact that the stabilizing arm can have several rings that are attached to several deflectable dental implants and enable distraction at the same time. • The distraction activator is unique in that it can be used to stabilize dental implants that are mobile due to peri-implantitis. The distracted implant can be stabilized while distraction osteogenesis of the surrounding bone or guided bone regeneration is performed. • The distraction activator is characterized by including a device to prevent activation of the device during the healing phase.

Oral administration of a bioavailable silicic acid, such as choline-stabilized silicic acid, daily for at least 3 months results in the prevention, inhibition, and / or treatment of periodontitis and peri-implantitis. This treatment is particularly suitable in combination with appropriate dental cleaning and oral disinfection by means of one or more antibacterial and / or antimicrobial agents, carried out at least once and appropriately regularly, such as once a year, twice a year, four times a year, or even once every two months or once a month. The treatment can be further enhanced by co-administering vitamins, trace elements, and by administering probiotics. Such other agents can be administered separately, but are preferably incorporated into a preparation of bioavailable silicic acid.

The present invention provides a composition comprising specific self-assembling peptides, which are capable of self-assembly at a pH below 7.5 and at least physiologic ionic strength, e.g., PI 1-4. PI 1-8, PI 1-14, PI 1-13, PI 1-12, PI 1-28, PI 1-29, PI 1-2, PI 1-5, PI 1-17, PI 1-19, PI 1-20, PI 1-12, PI 1-16, PI 1-18, PI 1-26 or PI 1-31 for use in treating an oral disease selected from the group consisting of gingivitis, periodontitis and / or peri-implantitis in a subject. Said composition may be used, after suitable cleaning procedures, for filling pockets formed adjacent to teeth in said diseases, which enhances tissue regeneration. The composition may be suitable for controlled release of an active agent, e.g., an antimicrobial or antibiotic agent. The invention also provides a kit suitable for said treatment further comprising self-assembling peptides suitable for forming a second layer on top of the first composition.

The invention discloses a peri-implantitis non-invasive detection method based on a spatial offset Raman spectrum technology, which comprises the following steps: S1, constructing adjustable spatial offset Raman detection equipment to obtain a calibration parameter set; s2, selecting an offset window with an optimal signal-to-noise ratio as a target acquisition window, and outputting optimized spatial offset Raman spectrum data; s3, performing wavelet multi-scale decomposition on the optimized spatial offset Raman spectrum data by adopting a preset mother wavelet to obtain a wavelet multi-scale coefficient set; s4, suppressing a background noise coefficient by adopting a self-adaptive threshold set, and reconstructing to obtain reconstructed de-noised spatial offset Raman spectrum data; s5, generating a three-dimensional space offset wavelet spectrum tensor, performing concentrated enhancement, and outputting enhanced space offset Raman spectrum data; and S6, obtaining a periimplantitis health state classification result and an inflammation index value. According to the invention, the detection sensitivity and accuracy of early weak signals of dental periimplantitis are obviously improved.

The present invention relates to a method, in particular an in vitro method, for a method for detecting peri-implantitis (PI) in a mammalian subject having a tooth implant, comprising detecting, and quantifying at least one protein in a sulcus fluid sample obtained from said subject that is enriched or depleted in the sample when compared to a sulcus fluid sample obtained from a healthy implant (I) and / or a healthy tooth (T), wherein an enrichment of at least one protein as identified and / or wherein a depletion of at least one protein as identified detects a PI in said subject. Furthermore, the present invention relates to the application of the findings of the invention in the development of new anti-PI therapies and as well as to a kit for performing the above methods as well as respective uses thereof. Finally, improved anti-PI compounds or pharmaceutical compositions are provided.