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Complex between lactoferrin and silica, process for the production thereof, and composition thereof for oral hygiene

a technology of complexes and silica, which is applied in the direction of silicon compounds, transferrins, animal/human proteins, etc., can solve the problems of affecting the quality of life of the organism, and loss of bone tissue and therefore of the implant itself, so as to achieve high stability and bioavailability

Inactive Publication Date: 2021-03-25
L I CO RICE SRL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The invention is a composition that contains lactoferrin and silica, which can be used in oral hygiene products such as toothpaste, gel, or mouthwash. The composition is stable and effective at fighting bacteria and reducing oxidation in the mouth for a long time. The addition of non-complexed silica helps to further stabilize the lactoferrin and silica complex, ensuring their interactions with other ingredients are not compromised. The composition can be dried using supercritical CO2 or lyophilization to ensure the silica and lactoferrin complex is stable without any denaturation or changes in structure. The composition can also be treated with polyol to further stabilize the structure.

Problems solved by technology

Periodontitis has a very high prevalence in the general population (around 10-15% of adults) and induces numerous negative effects on quality of life.
On the other hand, peri-implantitis is an inflammation process that affects the tissue surrounding an implant osseo-integrated implant, leading to a loss in the bone tissue and therefore in the implant itself.
Entering the systemic circle, these can negatively affect the organism.
The use of lactoferrin in the field of oral care products has currently not been widely used, mainly due to its poor stability and compatibility with the excipients normally used in oral care products, such as toothpastes, gels or mouthwashes.
Lactoferrin also has a relatively low bio-availability when applied topically and is subject to oxidative degradation phenomena.

Method used

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  • Complex between lactoferrin and silica, process for the production thereof, and composition thereof for oral hygiene
  • Complex between lactoferrin and silica, process for the production thereof, and composition thereof for oral hygiene
  • Complex between lactoferrin and silica, process for the production thereof, and composition thereof for oral hygiene

Examples

Experimental program
Comparison scheme
Effect test

examples 1-3

[0056]The compositions shown in Table 1 were prepared (% by weight of the total composition):

TABLE 1EXAMPLE123 (*)glycerol51.651.074.0water7.015.025.0hydrophilic40.030.0—silicarice husk0.43.0—silicalactoferrin1.01.0 1.0(*) comparative[0057]Hydrophilic silica: hydrophilic fumed silica having a specific surface area of about 200 m2 / g (BET area, measured according to standard ISO 9277-2010) (commercial product Aerosil™ 200 by Evonik);[0058]Rice husk silica: silica in the form of an aerogel having a specific surface area of about 550 m2 / g (BET area, measured according to standard ISO 9277-2010) and a density of about 0.050 g / cm3.

[0059]The rice husk silica and lactoferrin were previously complexed through the following process. The rice husk silica was prepared as described in Example 1 of WO 2016 / 193877, with the difference that, after obtaining the silica sol-gel, this was added to the lactoferrin and then subjected to drying with supercritical CO2 as described in the same Example 1, w...

examples 4-6

[0077]Examples 2 and 3 were repeated under the same conditions and with the same ingredients shown above (Examples 4 and 5). A further comparative example (Example 6) was also carried out, again with the same procedure and the same ingredients, wherein the lactoferrin was simply mixed with the hydrophilic silica, i.e. without preparing a complex according to the present invention, wherein silica is prepared in a sol-gel form, lactoferrin is added and then dried. The compositions are reported in Table 4 (% by weight of the total composition):

TABLE 4EXAMPLE45 (*)6 (*)glycerol51.074.051.0water15.025.015.0hydrophilic30.0—33.0silicarice husk3.0——silicalactoferrin1.0 1.0 1.0(*) comparative

[0078]Antioxidant and antibacterial properties of these compositions were verified, evaluating the variation of the efficacy over time, as described in Examples 1-3.

[0079]The results are reported in the following tables, where the left column shows the times (in minutes for Table 5 and in hours for Table...

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Abstract

Disclosed is a complex including at least one lactoferrin and at least one silica having a specific surface area included between 100 m2 / g and 1000 m2 / g (BET area, measured according to standard ISO 9277-2010), the complex being obtainable by adding the lactoferrin to the silica in the form of a sol-gel with an aqueous solvent, and subsequent drying of the sol-gel. The complex is particularly suitable for use in oral care products, in particular toothpastes, mouthwashes, gels, chewing gum, tablets for use in oral care, gingival dyes, and the like. The complex features a high level of stability and bio-availability, such that it has an effective, long-lasting antibacterial and antioxidant action within the oral cavity. The complex is particularly suitable for the prevention or treatment of diseases of dental apparatus, in particular for the prevention or treatment of periodontitis or peri-implantitis, preferably in patients suffering from diabetes.

Description

BACKGROUND OF THE INVENTIONField of the Invention[0001]The present invention relates to a complex comprising one lactoferrin and one silica, process for the production thereof, and a composition thereof for oral hygiene, in particular in cases of increased oxidative stress of the oral cavity.Description of the Related Art[0002]It is well known that oral hygiene is a determining factor in the prevention of diseases of the dental apparatus, such as caries, gingivitis, periodontitis, peri-implantitis, etc.[0003]Periodontitis is known to be a chronic inflammatory disease characterized by the destruction of the tooth's support structures (periodontal ligament, alveolar bone). Periodontitis has a very high prevalence in the general population (around 10-15% of adults) and induces numerous negative effects on quality of life.[0004]On the other hand, peri-implantitis is an inflammation process that affects the tissue surrounding an implant osseo-integrated implant, leading to a loss in the ...

Claims

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Application Information

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IPC IPC(8): A61K8/64A61K8/25A61Q11/00C01B33/158C01B33/148C07K14/79
CPCA61K8/64A61K8/25A61Q11/00A61K2800/84C01B33/148C07K14/79A61K2800/56C01B33/158
Inventor CISTERNAS CISTERNAS, JASNA ISABEL
Owner L I CO RICE SRL
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