The invention discloses a coating material for preventing an engine crankshaft from being locked, and a preparation method and an application method of the coating material. The coating material comprises the following raw materials in parts by weight: PAG (Polyalkylene Glycol ethers) polyether base oil, modified plant-based synthetic ester oxide sunflower oil, epoxy resin, organic molybdenum, tungsten disulfide powder, tungsten diselenide powder, carbon monofluoride powder, polyphenyl, a fire retardant, an antiwear agent and an antioxidant. The coating material is coated on a crankshaft neck surface and/or bearing bush surface between a crankshaft neck and a bearing bush (tile), so that a protective coating which is lubricant enough, and not easy to wash off or damage, and can bearing extremely high temperature is provided under the condition that the engine oil cannot provide effective lubricating due to poor quality, or cannot provide an enough lubricating effect between the crankshaft and a connecting rod due to reduction of the engine oil, the coating material has excellent waterproof properties, anti-rust characteristics, anti-corrosion property, and micro-grinding resistance on metal parts, can form solid dry film lubrication under the environment above 200 DEG C, and can play the roles in lubricating and preventing metal from being locked by sintering at the temperature which can be up to 1400 DEG C, and the locking phenomenon between the crankshaft and the connecting rod caused by dry friction between the tile and the crankshaft is effectively avoided.