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Implant material and preparation method and application thereof

A technology for implants and oral implants, applied in prosthesis, medical science, coating, etc., can solve problems such as easy infection and implant surgery failure.

Active Publication Date: 2022-07-29
SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in a complex microbial environment, simple titanium implants can easily cause infection, leading to peri-implantitis and failure of implant surgery

Method used

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  • Implant material and preparation method and application thereof
  • Implant material and preparation method and application thereof
  • Implant material and preparation method and application thereof

Examples

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preparation example Construction

[0044] Another aspect of the present invention provides a preparation method of implant material, and the preparation method comprises the following steps:

[0045]1) adding titanium rods and / or titanium sheets to an electrolyte containing calcium salts and phosphates for plasma oxidation treatment to prepare TiO 2 coating;

[0046] 2) adding zinc salt and strontium salt to the electrolyte solution described in step 1) to prepare the implant material.

[0047] In the preparation method of the implant material provided by the present invention, step 1) is to add titanium rods and / or titanium sheets to an electrolyte containing calcium salts and phosphates for plasma oxidation treatment to prepare TiO 2 coating. The titanium rod and titanium sheet need to be pre-treated, and the pre-treatment includes grinding and polishing 10mm×10mm×1mm or 20mm×20mm×1mm of commercial pure titanium or 2mm×7mm cylindrical commercial pure titanium, Wash with ethanol and deionized water in order...

Embodiment 1

[0061] Add β-glycerophosphate disodium salt (C 3 H 7 Na 2 O 6 P·5H 2 O, 50 mM) and calcium acetate monohydrate (C 4 H 6 O 4 Ca·H 2 O), configure the electrolyte containing calcium / phosphate, treat the titanium rod by plasma oxidation in the electrolyte containing calcium / phosphate, the titanium sheet is the anode, and the constant current with a duty ratio of 10% and a frequency of 800Hz is used The plasma electrolytic oxidation power supply, the current density is 30A / dm 2 , oxidized for 10 min to prepare TiO 2 coating. Continue to add zinc acetate (60 mM) and strontium acetate to the above electrolyte, wherein the total concentration of calcium acetate and zinc acetate is constant at 100 mM, and the molar ratio of Sr:(Sr+Ca) is adjusted to 1:4. The prepared sample was named 1SrZn@TiO 2 . like figure 1 , XRD test proves that the prepared TiO 2 The coatings are mainly rutile and anatase phases. like figure 2 The EDS of a shows that the mass percentages of each...

Embodiment 2

[0063] Add β-glycerophosphate disodium salt (C 3 H 7 Na 2 O 6 P·5H 2 O, 50 mM) and calcium acetate monohydrate (C 4 H 6 O 4 Ca·H 2 O), configure the electrolyte containing calcium / phosphate, treat the titanium rod by plasma oxidation in the electrolyte containing calcium / phosphate, and use the titanium sheet as the anode, using a constant duty cycle of 10% and a frequency of 800Hz. Flow plasma electrolytic oxidation power supply with a current density of 30A / dm 2 , oxidized for 10 min to prepare TiO 2 coating. Continue to add zinc acetate (60 mM) and strontium acetate to the above electrolyte, wherein the total concentration of calcium acetate and zinc acetate is constant at 100 mM, and the molar ratio of Sr:(Sr+Ca) is adjusted to 2:4. The prepared sample was named 2SrZn@TiO 2 . like figure 1 As shown, XRD examinations confirmed that the as-prepared TiO 2 The coatings are mainly rutile and anatase phases. like figure 2 The EDS of a shows that the mass percenta...

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Abstract

The invention relates to the technical field of biological materials, in particular to an implant material that can be used for osteoporosis patients and a preparation method and application thereof. The implant material includes TiO 2 coating, the TiO 2 The coating is doped with biological trace element components, the TiO 2 The mass percentage content of the coating is 74-78%, and the mass percentage content of the biological trace element component is 22-28%; the biological trace element component is selected from strontium and / or zinc. The implant material of the present application is a material that can promote osseointegration and bone regeneration around the implant material, optimizes the concentration of zinc and / or strontium on the surface of the implant, and has the advantages of promoting osteoporosis osteogenesis and implant osseointegration at the same time. Better antibacterial effect to prevent possible osseointegration and peri-implantitis resulting in implant failure after implant material is placed in osteoporotic patients.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to an implant material and a preparation method and application thereof. Background technique [0002] With the emergence of an aging society, osteoporosis has become a common chronic disease, and the number of patients is increasing day by day. It is mainly due to the abnormal bone metabolism of the elderly, the dynamic balance of bone resorption and formation is broken, and it develops in the direction of bone resorption, resulting in a decrease in bone density and bone destruction, thereby significantly reducing the quality of bone tissue in patients. Osteoporosis remains a contraindication to dental implant surgery so far. [0003] On the other hand, people are gradually paying more attention to oral health, and people's demands for restoration of missing teeth are gradually increasing. Oral implant technology was invented in the 1960s. Professor Branemark discove...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/30A61L27/32A61L27/50A61L27/54
CPCA61L27/306A61L27/32A61L27/50A61L27/54A61L2420/02A61L2430/02A61L2430/12A61L2300/404
Inventor 蒋欣泉文晋张翔凯王笑李金华
Owner SHANGHAI NINTH PEOPLES HOSPITAL SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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