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Implant material as well as preparation method and application thereof

A technology of implants and mass percentage, applied in the field of implant materials and their preparation, can solve the problems of easy infection, failure of implantation operation, etc.

Active Publication Date: 2020-07-31
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, in a complex microbial environment, simple titanium implants can easily cause infection, leading to peri-implantitis and failure of implant surgery

Method used

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  • Implant material as well as preparation method and application thereof
  • Implant material as well as preparation method and application thereof
  • Implant material as well as preparation method and application thereof

Examples

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preparation example Construction

[0044] Another aspect of the present invention provides a method for preparing an implant material, and the method for preparing comprises the following steps:

[0045]1) Add titanium rods and / or titanium sheets to an electrolyte containing calcium salt and phosphate for plasma oxidation to prepare TiO 2 coating;

[0046] 2) Add zinc salt and strontium salt to the electrolyte solution described in step 1) to prepare implant material.

[0047] In the preparation method of the implant material provided by the present invention, step 1) is to add titanium rods and / or titanium sheets into the electrolyte solution containing calcium salt and phosphate and perform plasma oxidation treatment to prepare TiO 2 coating. The titanium rod and the titanium sheet need to be pre-treated, and the pre-treatment includes grinding and polishing 10mm×10mm×1mm or 20mm×20mm×1mm flake commercial pure titanium or 2mm×7mm columnar commercial pure titanium, Clean with ethanol and deionized water in ...

Embodiment 1

[0061] Add β-glycerophosphate disodium salt (C 3 h 7 Na 2 o 6 P·5H 2 O, 50mM) and calcium acetate monohydrate (C 4 h 6 o 4 Ca·H 2 O), configure the electrolyte containing calcium / phosphate, the titanium rod is treated by plasma oxidation in the electrolyte containing calcium / phosphate, the titanium sheet is the anode, and the duty cycle is 10%, and the frequency is a constant current of 800Hz Plasma electrolytic oxidation power supply with a current density of 30A / dm 2 , oxidized for 10min to prepare TiO 2 coating. Continue to add zinc acetate (60mM) and strontium acetate to the above electrolyte, wherein the total concentration of calcium acetate and zinc acetate is constant at 100mM, and adjust the molar ratio of Sr:(Sr+Ca) to 1:4. The prepared sample was named 1SrZn@TiO 2 . like figure 1 , XRD detection proves that the prepared TiO 2 The coating is mainly rutile phase and anatase phase. like figure 2 The EDS of a shows that the mass percentages of each elem...

Embodiment 2

[0063] Add β-glycerophosphate disodium salt (C 3 h 7 Na 2 o 6 P·5H 2 O, 50mM) and calcium acetate monohydrate (C 4 h 6 o 4 Ca·H 2 O), the electrolyte containing calcium / phosphate is configured, and the titanium rod is treated by plasma oxidation in the electrolyte containing calcium / phosphate. The titanium sheet is used as the anode, and the duty ratio is 10%, and the constant frequency is 800Hz. Flowing plasma electrolytic oxidation power supply with a current density of 30A / dm 2 , oxidized for 10min to prepare TiO 2 coating. Continue to add zinc acetate (60mM) and strontium acetate to the above electrolyte, wherein the total concentration of calcium acetate and zinc acetate is constant at 100mM, and adjust the molar ratio of Sr:(Sr+Ca) to 2:4. The prepared sample was named 2SrZn@TiO 2 . like figure 1 As shown, XRD detection proves that the prepared TiO 2 The coating is mainly rutile phase and anatase phase. like figure 2 The EDS of a shows that the mass perc...

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Abstract

The invention relates to the technical field of biological materials, in particular to an implant material applicable to osteoporosis patients as well as a preparation method and application thereof.The implant material comprises a TiO2 coating, biological trace element components are doped in the TiO2 coating, the mass percentage of the TiO2 coating is 74%-78%, and the mass percentage of the biological trace element components is 22%-28%. The biological trace element components are selected from strontium and / or zinc. The implant material disclosed by the invention is a material capable of promoting osseointegration and bone regeneration around the implant material, and the concentration of zinc and / or strontium on the surface of the implant is optimized, so that the implant material hasa good antibacterial effect while promoting osteoporosis osteogenesis and implant osseointegration, and implant treatment failure caused by possible poor osseointegration and peri-implantitis after the implant material is implanted into an osteoporosis patient is prevented.

Description

technical field [0001] The invention relates to the technical field of biomaterials, in particular to an implant material and its preparation method and application. Background technique [0002] With the emergence of an aging society, osteoporosis has become a common chronic disease, and the number of patients is increasing day by day. It is mainly due to the abnormal bone metabolism in the elderly, the dynamic balance between bone resorption and formation is broken, and it develops in the direction of bone resorption, resulting in decreased bone density and bone destruction, resulting in a significant decline in the quality of bone tissue in the patient's body. Until now, osteoporosis is still a contraindication for dental implant surgery. [0003] On the other hand, people are gradually paying more attention to oral health, and people's demands for repairing missing teeth are gradually increasing. Dental implant technology was invented in the 1960s. Professor Branemark ...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/32A61L27/50A61L27/54
CPCA61L27/306A61L27/32A61L27/50A61L27/54A61L2420/02A61L2430/02A61L2430/12A61L2300/404
Inventor 蒋欣泉文晋张翔凯王笑李金华
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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