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Oral implant for preventing peri-implantitis

A technology for oral implants and implants, applied in the field of medical devices, can solve problems such as the inability to completely eliminate inflammation and reverse the loss of supporting tissue

Inactive Publication Date: 2020-07-31
SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, commonly used clinical treatment methods include mechanical therapy, drug therapy, sandblasting therapy, laser therapy and periodontal surgery, etc., but none of them can completely eliminate inflammation, reverse the loss of supporting tissue, and achieve ideal regeneration and osseointegration effects

Method used

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  • Oral implant for preventing peri-implantitis
  • Oral implant for preventing peri-implantitis
  • Oral implant for preventing peri-implantitis

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0029] The second aspect of the present invention provides the method for preparing the implant body for preventing peri-implantitis according to the first aspect of the present invention, comprising: preparing and obtaining the implant body by a micro-arc oxidation method.

[0030] In the preparation method provided by the present invention, a suitable method for preparing the implant body through the micro-arc oxidation method should be known to those skilled in the art. For example, the micro-arc oxidation method may specifically include: Electrolytic treatment of the implant body material.

[0031]In the electrolytic treatment, the electrolyte used can usually form a porous surface layer on the surface of the implant body material. The formula of suitable electrolytic solution should can be adjusted for those skilled in the art, for example, in described electrolytic treatment, used electrolytic solution can comprise phosphate and silicate, the phosphate in described elect...

Embodiment 1

[0038] Determination of Zn by cell experiments 2+ 、Sr 2+ Action concentration and usage ratio:

[0039] will contain different concentrations of Sr 2+ , Zn 2+ BMSCs were co-cultured with bone marrow mesenchymal stem cells (BMSCs), and the survival status of BMSCs was detected by the CCK-8 method. The specific method was as follows: seeded BMSCs in 96-well plates, and used 2+ , Zn 2+ The culture medium was cultured for 7 days, and then CCK8 was added at a ratio of 1:10, incubated at 37°C in the dark for 2 hours, the OD value was read by a microplate reader, and each experiment was repeated 3 times.

[0040] Specific experimental results such as figure 1 As shown in a), DM in the figure means ordinary DMEM medium without Zn and Sr ions. Depend on figure 1 a) It can be seen that BMSCs contain an appropriate concentration of Zn 2+ and Sr 2+ Higher cell viability in culture medium.

[0041] Further screening of Zn by ALP staining, real-time quantitative PCR and other meth...

Embodiment 2

[0044] Determination of Zn by bacterial experiments 2+ 、Sr 2+ Antibacterial effect:

[0045] By detecting the number changes of free S.M (Streptococcusmutans, Streptococcus mutans) and P.G (Porphyromonas gingivalis, Porphyromonas gingivalis) during the growth process at different times and in different ion environments, the growth curves are drawn. The specific method is as follows: S.M and P.G In a concentration of 40 μM Zn 2+ or 6mM Sr 2+ Cultured in BHI medium, at different times, the OD600 absorbance was detected by a microplate reader, and the growth curve was drawn.

[0046] Specific experimental results such as figure 2 a) as shown. Depend on figure 2 a) It can be seen that 40μM Zn 2+ , 6mM Sr 2+ Can inhibit the growth of S.M and P.G.

[0047] Detection of Zn using crystal violet staining 2+ 、Sr 2+ For the impact of S.M and P.G biofilm formation, the specific method is as follows: S.M and P.G are mixed at a concentration of 40 μM Zn 2+ or 6mM Sr 2+ Cultiv...

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Abstract

The present invention relates to the field of medical devices and particularly to an oral implant for preventing peri-implantitis. The provided oral implant for preventing peri-implantitis comprises an implant body and a porous surface layer distributed on the surface of the implant body, and the porous surface layer comprises Zn and Sr. The provided implant is simple in body structure and low inmanufacture cost. The surface of the implant body comprises the porous surface layer, besides, the porous surface layer is doped with Sr and Zn, the two elements can play a synergistic effect, so thatthe implant body has better osteogenic induction performance and microorganism inhibition functions. The implant body can be further used to prepare the oral implant. The oral implant shows excellenteffects in preventing and relieving peri-implantitis and thus has a good industrialization prospect.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an oral implant used for preventing peri-implantitis. Background technique [0002] Implant dentures have become the most ideal way to restore missing teeth due to their advantages of stability, comfort, and no damage to adjacent teeth. However, peri-implantitis often occurs with implant dentures, resulting in inflammatory damage to the surrounding soft tissue and loss of surrounding supporting tissue. According to reports, peri-implantitis occurs in 28% to 56% of patients and 12% to 43% of implants, and is currently the most important cause of implant failure. [0003] The initiating factor of peri-implantitis is plaque accumulation. At present, the commonly used clinical treatment methods include mechanical therapy, drug therapy, sandblasting therapy, laser therapy and periodontal surgery, etc., but none of them can completely eliminate inflammation, reverse the loss of support...

Claims

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Application Information

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IPC IPC(8): A61L27/30A61L27/56C25D11/02C25D11/26
CPCA61L27/56A61L27/306C25D11/026C25D11/26A61L2300/41
Inventor 蒋欣泉张文杰殷实
Owner SHANGHAI NINTH PEOPLES HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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