Silicic acids for use in treatment of periodontitis

A technology for periodontitis and peri-implantitis, applied in dentistry, cosmetic preparations, active ingredients of silicon compounds, etc., can solve the problems of preventing peri-implantitis and regeneration of gingiva and alveolar bone that cannot be expected

Pending Publication Date: 2021-08-06
BIO MINERALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In conclusion, non-surgical treatment has not been able to predictably prevent peri-implantitis
[0015] Therefore, there is a need for improved non-invasive, non-surgical therapies, as professional cleaning (oral disinfection) and the use of specific probiotics have not been shown to be curative, i.e. it at least partially eliminates the cause of the infection, but these treatments do not achieve gingival and alveolar bone regeneration
Furthermore, the authors observe that this result is only valid for specific bacteria

Method used

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  • Silicic acids for use in treatment of periodontitis
  • Silicic acids for use in treatment of periodontitis
  • Silicic acids for use in treatment of periodontitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] In dental practice, clinical tests were performed on patients with periodontitis. 40 patients with periodontitis were randomly selected. Standard treatment of scaling and root planing was given to all 40 patients. 40 patients were divided into two treatment groups, 20 patients in each group. Patients in the first treatment group were given a bioavailable form of silicon in solid form (bioavailable silicic acid) for twice daily oral dosing. Silicon in biological form is available from Bio Minerals N.V., Deisterbergen, Belgium under the tradename Commercially available. This formulation contains choline stabilized orthosilicic acid Among them, choline chloride is used to stabilize silicic acid. The formulation also contains microcrystalline cellulose as a carrier. Solid encapsulated formulations are prepared by extrusion and packaged in high-density polyethylene bottles that are magnetically sealed to ensure constant humidity levels. The remaining 20 patients ser...

Embodiment 2

[0062] A clinical test was performed in a dental practice on periodontitis patients with residual periodontal pockets. Ten patients with periodontitis who had received standard treatment (scaling and root planing) but who had deep periodontal pockets despite standard treatment were randomly selected.

[0063] After standard therapy, all 10 patients were orally administered a solid form of silicon in bioavailable form available from Bio Minerals N.V., Deisterbergen, Belgium under the tradename Commercially available. This formulation contains choline stabilized orthosilicic acid Among them, choline chloride is used to stabilize silicic acid. The formulation also contains microcrystalline cellulose as a carrier. Solid encapsulated formulations are prepared by extrusion and packaged in high-density polyethylene bottles that are magnetically sealed to ensure constant humidity levels. Treatment was assessed by measuring periodontal pocket depth on probing (PPD) and bleeding o...

Embodiment 3

[0066] Administration of choline-stabilized orthosilicic acid to two individual patients with chronic periodontitis A form of bioavailable silicic acid in which choline chloride is used to stabilize the silicic acid. The first patient was a 56-year-old nonsmoking male patient. The second patient was a 36-year-old non-smoking female patient. result in Figure 3A and Figure 3B shown in , where the color provides an indication of the pocket depth. The actual depth is also indicated for each tooth. Data were obtained by measuring the periodontal pocket depth around each tooth in the oral cavity 6 times. In both cases, periodontitis was significantly reduced. Before treatment, the patient had very deep periodontal pockets. After treatment, this was reduced to low depths (less than 3mm).

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Abstract

The oral administration of bioavailable silicic acid, such as choline-stabilized silicic acid during a period of at least 3 months daily leads to the prevention, inhibition and or treatment of periodontitis and peri-implantatis. The treatment is particularly suitable in combination with appropriate cleaning of the teeth and disinfecting the mouth, by one or more antiseptic and / or antimicrobial agent(s), as carried out at least once and suitably regularly, such as once per year, twice per year, four times per year or even every second month or every month. The treatment may be further enhanced by simultaneous administration of vitamins, trace elements, as well as by administration of a probioticum. Such additional agents may be applied separately, but are preferably incorporated in the formulation of bioavailable silicic acid.

Description

technical field [0001] The present invention relates to compounds and pharmaceutical compositions for preventing, inhibiting and / or treating periodontitis and / or peri-implantitis. Background technique [0002] Periodontitis and peri-implantitis are dental diseases. Periodontal destruction in periodontitis is initiated by the host's response to pathogenic bacteria capable of accumulating on the tooth, initially causing inflammation of the gingiva and eventually leading to destruction of the periodontal ligament and supporting bone. The latter can lead to loose teeth and potential tooth loss. In peri-implantitis, the hard tissue surrounding a dental implant degenerates, resulting in bone loss and potential implant loss. Both diseases are caused by periodontal pathogens and have similar clinical presentations, including deep probing and bleeding. Even the microbes grown from both were similar. The diseases vary histologically and pathologically. Most importantly for clinic...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/695A61P1/02A61K8/58A61Q11/00A61K47/10A61K9/00A61K9/14
CPCA61K9/0063A61K9/146A61K31/695A61K47/10A61P1/02A61Q11/00A61K8/585A61K47/24A61K9/0053A61K31/122A61K31/375A61K31/593A61K33/00A61K33/04A61K33/06A61K33/22A61K33/30A61K33/34A61K35/741A61K45/06
Inventor 马里奥·雷米·伊冯娜·卡洛梅凯瑟琳·约瑟夫·英格丽德·苏珊妮·范·霍夫
Owner BIO MINERALS
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