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Preparation method of furaltadone hydrochloride

A kind of technology of furaltadone hydrochloride and morpholine, which is applied in the preparation field of furaltadone hydrochloride, and can solve the problems of unsatisfactory product purity, impact on economic benefits, poor product yield and the like

Inactive Publication Date: 2020-08-07
衢州伟荣药化股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

The purity of the product prepared by the preparation method of furaltadone hydrochloride cannot meet the higher needs of customers. In addition, the product yield is not good, which affects economic benefits

Method used

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  • Preparation method of furaltadone hydrochloride
  • Preparation method of furaltadone hydrochloride
  • Preparation method of furaltadone hydrochloride

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Embodiment Construction

[0027] It should be understood that the specific embodiments described here are only used to explain the present application, and are not intended to limit the present application.

[0028] In the process of implementing this application, the inventor found that in the related art, the product purity obtained by the preparation method of furaltadone hydrochloride cannot meet the higher needs of customers. In addition, the product yield is not good, which affects economic benefits .

[0029] In order to solve the above problems, the embodiment of the present application provides a preparation method of furaltadone hydrochloride, which can make the product with higher purity and higher yield.

[0030] The preparation method of furaltadone hydrochloride comprises the steps of: preparing 4-(2,3-epoxypropyl)morpholine; preparing furaltadone hydrochloride with 4-(2,3-epoxypropyl)morpholine as one of the raw materials ketone.

[0031] Among them, "preparing 4-(2,3-epoxypropyl) morp...

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Abstract

The invention discloses a preparation method of furaltadone hydrochloride. The preparation method comprises the following steps: providing morpholine and epoxy chloropropane; reacting morpholine withepoxy chloropropane to obtain a first intermediate product; providing a sodium hydroxide aqueous solution; reacting the first intermediate product under an alkaline condition provided by a sodium hydroxide aqueous solution to obtain a second intermediate product; providing an extractant; extracting the second intermediate product by adopting an extracting agent to obtain an extracting phase; distilling the extraction phase to obtain 4-(2, 3-epoxypropyl)morpholine; preparing the furaltadone hydrochloride by taking 4-(2, 3-epoxypropyl)morpholine as one of the raw materials. The product preparedby adopting the preparation method disclosed by the invention is higher in purity, higher in yield and better in safety in the production process, and is more suitable for industrial production.

Description

technical field [0001] The application relates to the field of chemical industry, in particular to a preparation method of furaltadone hydrochloride. Background technique [0002] In the related art, the trade name of furaltadone hydrochloride is: furomazodone, the molecular formula is C13H16N4O6.HCL.H2O, and the chemical name is: 5-(4-morpholinomethyl)-3-[(5-nitro-2 -furyl)methylene]amino-2-oxazolidinone hydrochloride. The purity of the product prepared by the preparation method of furaltadone hydrochloride cannot meet the higher requirements of customers. In addition, the product yield is not good, which affects economic benefits. Contents of the invention [0003] The embodiment of the present application provides a preparation method of furaltadone hydrochloride, which can make the obtained product have higher purity and higher yield, and the preparation process is also safer. [0004] In the first aspect, the embodiment of the present application provides a preparat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D301/00C07D303/36
CPCC07D301/00C07D303/36
Inventor 吴伟荣徐一荃
Owner 衢州伟荣药化股份有限公司
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