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Vaccines against hendra and nipah virus infection

A Nipah virus and vaccine technology, applied in the direction of viruses, vaccines, viral peptides, etc., can solve the problems of high cost and difficulty of vaccines and/or diagnostic agents

Pending Publication Date: 2020-08-07
ZOETIS SERVICE LLC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Furthermore, since these viruses are zoonotic Biosafety Level 4 pathogens (BSL-4), it is extremely costly and difficult to safely produce vaccines and / or diagnostics

Method used

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  • Vaccines against hendra and nipah virus infection
  • Vaccines against hendra and nipah virus infection
  • Vaccines against hendra and nipah virus infection

Examples

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Embodiment Construction

[0013] definition

[0014] "About" or "approximately" when used in connection with a measurable numerical variable refers to the indicated value of the variable and to the indicated value of the variable within the experimental error of the indicated value (eg, within the 95% confidence interval of the mean) or all values ​​within 10% of the indicated value, whichever is greater, unless about refers to a time interval in weeks, where "about 3 weeks" is 17 to 25 days, and about 2 to about 4 A week is 10 to 40 days.

[0015] "Antigen" or "immunogen" refers to any substance that is recognized by an animal's immune system and that produces an immune response. The term includes killed, inactivated, attenuated or modified live bacteria, viruses or parasites. The term "antigen" also includes polynucleotides, polypeptides, recombinant proteins, synthetic peptides, protein extracts, cells (including tumor cells), tissues, polysaccharides or lipids or fragments thereof, alone or in an...

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Abstract

Disclosed is a method of protecting an animal in need thereof from Hendra or Nipah virus infection comprising administering to said animal a single dose of a vaccine, the vaccine comprising:an antigencomponent comprising a Hendra antigen or a Nipah antigen; and an adjuvant comprising oil, polycationic carrier and a CpG containing immunostimulatory oligonucleotide, wherein the vaccine is a W / O emulsion.

Description

[0001] field of invention [0002] The present invention is generally in the field of animal vaccines against Hendra virus (HeV) and Nipah virus (NiV) infection. [0003] Background of the invention [0004] Paramyxoviruses, such as HeV and NiV, have two major membrane-anchored glycoproteins in the outer membrane of the virion. One glycoprotein is required for virions to attach to receptors on host cells and is named hemagglutinin-neuraminidase protein (HN) or hemagglutinin protein (H), while the other is neither Glycoprotein (G) that has both hemagglutination and neuraminidase activity. Attachment glycoproteins are type II membrane proteins in which the amino (N) terminus of the molecule is oriented toward the cytoplasm and the carboxyl (C) terminus of the protein is extracellular. The other major glycoprotein is the fusion (F) glycoprotein, a trimeric class I fusogenic outer membrane glycoprotein containing two heptad repeat (HR) regions and a hydrophobic fusion peptide. A...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/155A61P31/14
CPCA61K39/12A61K39/39A61P31/14C07K14/005A61K2039/55566C12N2760/18234A61K2039/552A61K2039/55561A61K2039/55583A61K39/155
Inventor P·J·多明诺夫斯基D·M·姆旺吉D·L·福斯S·K·雷J·M·哈德汗姆
Owner ZOETIS SERVICE LLC