Application of mixture of lactobacillus plantarum capable of degrading tryptophan and tryptophan

Abstract

The invention discloses an application of a mixture of lactobacillus plantarum capable of degrading tryptophan and tryptophan, and specifically discloses an application of the mixture of lactobacillusplantarum capable of degrading tryptophan and tryptophan to reducing the activity of myeloperoxidase MPO in colon tissue, an application of the mixture of lactobacillus plantarum capable of degradingtryptophan and tryptophan to improving immune response disorder of colitis, an application of the mixture of lactobacillus plantarum capable of degrading tryptophan and tryptophan to protecting intestinal barriers, an application of the mixture of lactobacillus plantarum capable of degrading tryptophan and tryptophan to protecting intestinal mucosa and an application of the mixture of lactobacillus plantarum capable of degrading tryptophan and tryptophan to regulating intestinal microorganisms. Through in vitro assessment of the degrading capacity of 16 pieces of lactobacilli on the tryptophan, lactobacillus plantarum KLDS1.0386 having high tryptophan degrading capacity is screened out, and the lactobacillus plantarum KLDS1.0386 has good growth properties, has high acid production capacity, acid resistance and cholate resistance, and shows favorable probiotic functions and colitis preventing functions.

Description

technical field [0001] The invention relates to the application of a mixture of Lactobacillus plantarum and tryptophan that can degrade tryptophan, in particular to the application of a mixture of Lactobacillus plantarum and tryptophan that can degrade tryptophan in the prevention of colitis, which belongs to medicine technology field. Background technique [0002] Inflammatory bowel disease (Inflammatory bowel disease, IBD) is a chronic and relapsing autoimmune disease, including ulcerative colitis (ulcerative colitis, UC) and Crohn's disease (Crohn's disease, CD) two disease types . In the past, IBD was considered to be a western disease, mainly concentrated in developed countries such as North America, Europe, Australia, and New Zealand. In recent years, the incidence of IBD in emerging industrial countries such as Asia and the Middle East has risen sharply, and it has developed into a global disease. The clinical manifestations of IBD are diarrhea, hematochezia, and we...

AI Technical Summary

Problems solved by technology

However, the ability of intestinal microorganisms to decompose and utilize tryptophan is limited. Current studies have found that Escherichia coli, Clostridium, Bacteroides, and Peptostreptococcus have the function of degrading tryptophan. Enterococcus strains can use tryptophan, but Enterococcus is a potentially pathogenic pathogenic bacteria, the safety of the strains to the human body cannot be guaranteed

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