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Methods of assessing risk of developing breast cancer

A technique for breast cancer, risk, applied in the direction of mammography, biochemical equipment and methods, drugs or prescriptions

Pending Publication Date: 2020-08-28
GENETIC TECHNOLOGIES LIMTIED +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the first clinical risk assessment component of these tests is subject to the aforementioned limitations of self-reported clinical information

Method used

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  • Methods of assessing risk of developing breast cancer
  • Methods of assessing risk of developing breast cancer
  • Methods of assessing risk of developing breast cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0287] Example 1 - A first clinical risk assessment, a second clinical risk assessment based at least on breast density and genetic risk combination of risk assessments

[0288] The inventors found that a breast cancer risk model combining a first clinical risk estimate, at least a second clinical risk estimate based on breast density, and a genetic risk estimate provides better risk discrimination than any currently available individual risk model.

[0289] The model was developed using 800 breast cancer subjects and 2000 control subjects and cross-validated using a second independent cohort comprising 1259 breast cancer subjects and 1800 controls.

[0290] From a public health perspective, the key question is the extent to which risk factors in a given population distinguish breast cancer subjects from control populations. This can be determined from the risk gradient, best expressed as the change in odds per adjusted standard deviation (OPERA) of a risk factor in the po...

Embodiment 2

[0297] Example 2 Absolute Risk Estimation

[0298] In the case of cancer risk assessment, it is often more useful to provide an absolute estimate of cancer risk (ie, a risk related to an individual rather than a population relative risk). Absolute risk is usually described as remaining lifetime risk or short-term risk, such as 5-year risk or 10-year risk (which describe the risk of developing cancer in the next 5 or 10 years, respectively).

[0299] Absolute risk of breast cancer can be derived from risk models by combining specific incidence and competing mortality rates of breast cancer in the population under consideration, which allows estimating the risk of dying from causes other than breast cancer.

[0300] The following specific data domains can be included in the model to determine the absolute risk of breast cancer:

[0301] Details based on age, ethnic group, height, weight, menarche, menopause, childbirth history, use of contraceptive methods, use of hormone rep...

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Abstract

Methods and systems for assessing the risk of a human female subject for developing breast cancer. In particular, the present disclosure relates to combining a first clinical risk assessment, a secondclinical assessment based at least on breast density, and a genetic risk assessment, to obtain an improved risk analysis.

Description

technical field [0001] The present disclosure relates to methods and systems for assessing the risk of breast cancer in a human female subject. In particular, the present disclosure relates to combining a first clinical risk assessment, at least a second clinical assessment based on breast density, and a genetic risk assessment to improve risk analysis. Background technique [0002] It is estimated that about one in eight women in the United States will develop breast cancer in their lifetime. More than 230,000 women are expected to be diagnosed with invasive breast cancer in 2013 and nearly 40,000 will die from the disease (ACS Breast Cancer Facts & Figures 2013-14). Therefore, there is a compelling reason to predict which women will develop the disease and to take steps to prevent it. [0003] Extensive research has focused on phenotypic risk factors, including age, family history, reproductive history, and benign breast disease. Various combinations of these risk facto...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/6886
CPCC12Q1/6886A61B5/4312G16H50/20C12Q2600/118C12Q2600/156C12Q2600/112A61B5/0091A61B10/0041G16H20/10G16H50/30
Inventor 理查德·奥尔曼吉莉安·迪特约翰·霍珀
Owner GENETIC TECHNOLOGIES LIMTIED
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