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Method for creating histopathological ground truth masks using slide restaining

A slide and mask technology, applied in the field of digital pathology, which can solve the problems of ground truth labels and inaccurate masks

Pending Publication Date: 2020-08-28
GOOGLE LLC
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the morphological differences in successive slices are still significant and may lead to inaccurate ground-truth labels and masks generated in this way.

Method used

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  • Method for creating histopathological ground truth masks using slide restaining
  • Method for creating histopathological ground truth masks using slide restaining
  • Method for creating histopathological ground truth masks using slide restaining

Examples

Experimental program
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Embodiment Construction

[0039] now turn your attention to figure 1 , figure 1 is an illustration of a laboratory 100 environment in which the method is practiced. A tissue sample, typically formalin-fixed and typically paraffin-embedded, is placed on a microscope slide 102 and the tissue sample is placed into a stainer 104 that applies a stain to the tissue sample. Commercial stainers for applying H&E, IHC, and other specific stains to tissue samples are known and available from a number of suppliers. Initially, the stainer 104 stains the slide with H&E stain and places a cover slip over the tissue sample. Then, as indicated at 105 , the slide is provided to a full slide scanner 106 . Such scanners are also widely known and available from a number of suppliers. The whole slide scanner 106 scans the slide at a user specified magnification such as 10X, 20X or 40X. Whole slide scanners include digital cameras that capture magnified color digital images of the specimen. The digitally enlarged ima...

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Abstract

A method for generating a ground truth mask for a microscope slide having a tissue specimen placed thereon includes a step of staining the tissue specimen with hematoxylin and eosin (H&E) staining agents. A first magnified image of the H&E stained tissue specimen is obtained, e.g., with a whole slide scanner. The H&E staining agents are then washed from the tissue specimen. A second, different stain is applied to the tissue specimen, e.g., a special stain such as an IHC stain. A second magnified image of the tissue specimen stained with the second, different stain is obtained. The first and second magnified images are then registered to each other. An annotation (e.g., drawing operation) is then performed on either the first or the second magnified images so as to form a ground truth mask,the ground truth mask in the form of closed polygon region enclosing tumor cells present in either the first or second magnified image.

Description

Background technique [0001] The present disclosure relates to the field of digital pathology, and more particularly, to a method for generating a ground truth mask in a digital image of a tissue sample. In this document, the term "mask" refers to a closed polygonal region in an image of a tissue sample that encloses a region of interest, such as tumor cells (eg, cancer). In this document, the term "ground truth" refers to a mask provided by direct observation of the sample (i.e., empirical evidence), as opposed to information provided by inference, and a label (e.g., "cancerous") that can be assigned to a tissue sample . [0002] Digital images of tissue samples with ground-truth masks for the samples and associated labels (eg, "cancerous") are used in a variety of contexts, including as training examples for building machine learning models. Such machine learning models can be developed for a variety of purposes, including aiding in diagnosis, clinical decision support, and...

Claims

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Application Information

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IPC IPC(8): G06K9/00
CPCG06V20/69G01N1/30G01N1/34G06T7/0012G06T2207/20081G06T2207/20084G06T2207/30024G06V20/695
Inventor L.彭M.施通佩
Owner GOOGLE LLC
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