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Application of Pingwoju Sanqi in the preparation of medicine for treating ulcerative colitis

A technology of ulcerative colitis and supine chrysanthemum notoginseng, which is applied in the field of medicine, can solve problems such as skin necrosis, discomfort, and fever, and achieve the effect of easy acceptance, wide sources, and good curative effect

Active Publication Date: 2021-07-13
唐和斌
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Sulfasalazine is currently the first-choice drug, and the effective rate of relieving ulcerative colitis can be as high as 80%. It is often used in the treatment of mild and medium-sized patients. Necrosis; also easily lead to adverse reactions such as sore throat, nausea, vomiting, abdominal discomfort (pancreatitis, hepatitis)

Method used

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  • Application of Pingwoju Sanqi in the preparation of medicine for treating ulcerative colitis
  • Application of Pingwoju Sanqi in the preparation of medicine for treating ulcerative colitis
  • Application of Pingwoju Sanqi in the preparation of medicine for treating ulcerative colitis

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] The preparation of embodiment 1 flat lying chrysanthemum notoginseng extract

[0027] Pingwo chrysanthemum notoginseng is produced in Baoting, Hainan Province, and was identified by Mr. Lu Xiaozhou from Baoting Institute of Tropical Crops in Hainan Province. Take 5 kg of dried stems and crush them, add 80v / v% ethanol, reflux extraction at 85°C for 3 times, each time for 2h, add 50L of 80v / v% ethanol each time, filter, combine the three extracts and use a rotary evaporator for 60 Concentrate and dry at ℃ to obtain a dry extract, which is the ethanol extract of Pingbu notoginseng, with a yield of 18.5%. Using the external standard method described in claim 2 in the application publication text CN104931620A of Chinese invention patent ZL201510388257.3, the content of chlorogenic acid in the ethanol extract of Pingbu notoginseng was measured to be 2.75 μg / mg, neochlorogenic acid, iso The contents of chlorogenic acid A, isochlorogenic acid B and isochlorogenic acid C were 0...

Embodiment 2

[0028] Example 2 Application of Suppressed Ju Notoginseng in the Preparation of Medicines for Treating Ulcerative Colitis

[0029] 1 animal

[0030] SPF grade male BALB / c mice (No. 42000600024951), 52 in total, weighing 18-20 g. The lighting time of the mice was a cycle of 12 / 12h (lighting 12h, dark 12h), and the mice kept eating and drinking freely during the experiment.

[0031] 2 Modeling and intervention

[0032] (1) modeling

[0033] With reference to literature (Wirtz S, Neufert C, Weigmann B, et al.Chemically induced mousemodels of intestinal inflammation.Nature Protocols, 2006,2(3):541-546) to obtain 2,4,6-trinitrobenzenesulfonic acid ( TNBS)-induced ulcerative colitis in mice. Animals were deprived of food and water before modeling.

[0034] Pre-sensitization:

[0035] After the mouse was anesthetized with 10% chloral hydrate (0.125 mL / 10 g), the mouse was placed on a constant temperature warming pad, and a 1.5 cm×1.5 cm area was shaved on its back with a razor....

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Abstract

The invention relates to the technical field of medicines, in particular to the application of flat lying chrysanthemum notoginseng in the preparation of medicines for treating ulcerative colitis. The ethanol extract of Pingbu notoginseng was used as a gavage preparation for experimental mice, and remarkable effects were achieved during the experiment. The results of the animal experiments showed that the results of H&E staining and PAS staining of the colon tissue: Both the high and low dose groups can maintain the structure of the colonic mucosa, and can also significantly control the secretion of glycogen, especially the high dose can make the tissue approach the physiological state of the normal group, and the effect is also better than that of sulfasalazine pyridine group. It shows that the extract of Pingwo chrysanthemum notoginseng has a good application prospect in the repair of intestinal mucosal barrier damage in ulcerative colitis, with definite curative effect and no toxic and side effects, and its extraction and preparation methods are easy to implement, and its application prospect is broad.

Description

technical field [0001] The invention relates to the technical field of medicines, in particular to the application of flat lying chrysanthemum notoginseng in the preparation of medicines for treating ulcerative colitis. Background technique [0002] Ulcerative colitis is a kind of chronic non-specific colonic inflammation with unknown etiology, easy to relapse, and one of the more common diseases that are difficult to cure completely in the digestive system diseases of internal medicine. Its clinical manifestations are recurrent abdominal pain, diarrhea, pus and blood in the stool, nausea, vomiting, fever, etc., accompanied by liver damage, concurrent osteoarthritis, skin lesions, cardiomyopathy, iridocyclitis, and various endocrine diseases Wait. Its course of disease is long, is difficult to thoroughly cure, protracts easily, even malignantly becomes cancer. [0003] Epidemiological statistics in recent years show that the incidence of ulcerative colitis in Asia shows a ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/28A61P1/00
CPCA61K36/28A61P1/00
Inventor 刘立新唐东杰
Owner 唐和斌
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