Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

CYPY and application thereof in preparation of antitumor drugs

A technology of anti-tumor drugs and compounds, which is applied in the application field of the new type of cyanine dye CYPY in the preparation of anti-tumor drugs, and can solve the problems of no anti-tumor activity

Active Publication Date: 2020-09-18
HENAN UNIVERSITY
View PDF2 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The design and synthesis of the new pentamethylcyanine dye CYPY and its application in the preparation of antitumor drugs is the first study of this research group,

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • CYPY and application thereof in preparation of antitumor drugs
  • CYPY and application thereof in preparation of antitumor drugs
  • CYPY and application thereof in preparation of antitumor drugs

Examples

Experimental program
Comparison scheme
Effect test
No Example Login to View More

PUM

PropertyMeasurementUnit
Ic50 valueaaaaaaaaaa
Ic50aaaaaaaaaa
Login to View More

Abstract

The invention belongs to the technical field of chemical medicine, and relates to application of 1, 5-bis [N-(3, 5-bis (2-(2-methoxyethoxy) ethoxy) ethoxy) benzyl-2, 3, 3-trimethyl-3H-indole]-3-(4-pyridine) penta-carbonyanine bromide dye (CYPY for short) in preparation of antitumor drugs. MTT results show that CYPY can significantly inhibit the activity of colorectal cancer cells in DLD-1 and SW480 cells. Animal experiment results show that CYPY significantly inhibits the growth of human colorectal cancer cell line DLD-1 BALB/C nude mouse subcutaneous tumor-bearing, and can be used for preparing antitumor drugs. The compound CYPY disclosed by the invention is developed as a novel anti-tumor drug or an auxiliary component thereof, has a remarkable tumor inhibition effect, and provides a newtreatment way and means for treating and curing tumors.

Description

technical field [0001] The invention belongs to the technical field of chemical industry and medicine, and in particular relates to the application of a new type of Wujiachuan cyanine dye CYPY in the preparation of antitumor drugs. Background technique [0002] With the increase of the global population, the environmental problems caused by factors such as aging and environmental pollution are becoming more and more prominent, and the detection rate and incidence of malignant tumors are increasing year by year; tumors have become one of the most serious diseases threatening human beings in modern society According to relevant surveys, cancer is the first cause of death in developing countries and the second cause of death in developed countries. Cancer is called a "disease of the elderly", but in recent years, the younger trend of cancer has become more and more obvious. With the application of new technologies in diagnosis and treatment and the continuous development of ch...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C09B23/10C07D401/14A61K41/00A61P35/00
CPCC09B23/107C07D401/14A61K41/0052A61K41/0057A61P35/00
Inventor 张磊王群陈明亮常海波刘徐倩史霄汤昆姜笑梅节茹郏若涵刘文青刘芳艳贾爽爽
Owner HENAN UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com