Novel combination and use of antibodies

A use, antibody technology, applied in the direction of antibody, drug combination, anti-animal/human immunoglobulin, etc., can solve the problem of no inspection or proof

Pending Publication Date: 2020-09-18
BIOINVENT INT AB +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, it was not examined or demonstrated whether such antibodies would also have utility in the treatment of FcγRIIB negative cancers such as solid cancers

Method used

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  • Novel combination and use of antibodies
  • Novel combination and use of antibodies
  • Novel combination and use of antibodies

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0022] Therefore, the present invention relates to the following combined use:

[0023] (i) an antibody molecule that specifically binds FcγRIIb through its Fab region and lacks an Fc region or has reduced binding to an Fcγ receptor through its Fc region (hereinafter generally expressed as a first antibody molecule or the first antibody molecule ),as well as

[0024] (ii) an antibody molecule that specifically binds to a receptor present on an immune cell (hereinafter generally expressed as a second antibody molecule or the second antibody molecule), wherein the immune cell suppresses anticancer immunity of immune cells, said antibody molecule has an Fc region that binds to at least one activated Fcγ receptor, and wherein said binding of said antibody molecule to said receptor on said immune cell causes depletion of said immune cell or Deactivate. Thus, this second antibody molecule is an immune cell depleting or deactivating antibody molecule.

[0025] This combination is ...

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Abstract

Described is the use of a first antibody molecule that specifically binds Fc gamma Rllb via its Fab region, but lacks Fc region or has reduced binding to Fc gamma receptors via its Fc region, for usein combination with a second antibody molecule that specifically binds to a receptor present on an immune cell, wherein the immune cell is an immune cell that suppresses anti-cancer immunity, which second antibody molecule has an Fc region that binds to at least one activating Fc gamma receptor, and wherein the binding of the second antibody molecule to the receptor on the immune cell causes depletion and / or deactivation of the immune cell in the treatment of an Fc gamma Rllb-negative cancer in a patient, as well as pharmaceutical compositions and kits comprising these to antibody molecules, and methods of treating cancer using these two antibodies.

Description

technical field [0001] The present invention relates to the use of antibody molecules: 1) antibody molecules that specifically bind FcγRIIb via their Fab region, but lack or have reduced binding to at least one Fcγ receptor via their Fc region; and 2) immunization A cell-depleting or deactivating antibody molecule that specifically binds to a receptor present on an immune cell that suppresses anti-cancer immunity and that depletes the immune cell A neutral or deactivating antibody molecule having an Fc region that binds at least one activating Fcγ receptor, said antibody molecule and said immune cell depleting or deactivating antibody molecule being used in combination for the treatment of FcγRIIb negative cancers. Background technique [0002] It has long been recognized that the inhibitory Fcy receptor (FcyR) IIB expressed by numerous cells of the immune system negatively regulates both innate and adaptive immunity by engaging immune complexes (ICs). Similarly, the knowle...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/28A61P35/00
CPCC07K16/2818C07K16/2827C07K16/283C07K16/2866C07K16/2887A61K2039/507C07K2317/41C07K2317/526C07K2317/71C07K2317/76A61P35/00C07K16/28C07K2317/54C07K2317/55C07K2317/569
Inventor B·弗伦德修斯英格丽德·泰格L·玛藤松马克·克拉格斯蒂芬·贝尔斯阿里·鲁加尼安R·奥尔德姆
Owner BIOINVENT INT AB
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