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Sample carrier for optical measurements

An optical measurement and sample technology, applied in the direction of optics, measuring devices, optical components, etc., can solve problems such as wrong results

Pending Publication Date: 2020-10-16
S D SIGHT DIAGNOSTICS LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This may lead to the risk of erroneous results, i.e. diagnostics on subsequent samples placed in the sample carrier after the diagnostic has already been used, due to cross-contamination and / or residues left in the sample carrier from previous uses

Method used

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  • Sample carrier for optical measurements
  • Sample carrier for optical measurements
  • Sample carrier for optical measurements

Examples

Experimental program
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Embodiment Construction

[0089] now refer to figure 1 , figure 1 is a block diagram illustrating components of a biological sample analysis system 20 according to some applications of the invention. Typically, a biological sample, such as a blood sample, is placed in sample carrier 22 . While the sample is placed in the sample carrier, optical measurements are taken of the sample using one or more optical measurement devices 24 . For example, optical measurement devices may include microscopes (e.g., digital microscopes), spectrophotometers, photometers, spectrometers, cameras, spectral cameras, hyperspectral cameras, fluorometers, spectrofluorometers, and / or photodetectors (e.g., photodiodes, photosensitive resistors and / or phototransistors). For some applications, optical measurement devices include dedicated light sources (eg, light emitting diodes, incandescent light sources, etc.) and / or optical elements (eg, lenses, diffusers, filters) for manipulating light collection and / or emission. For c...

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Abstract

Apparatus and methods are described including a sample carrier (22) configured to carry a portion of a bodily sample, at least a portion of the sample carrier being configured to fluoresce, at least under certain conditions. An optical measurement device (24) performs optical measurements upon the portion of the bodily sample that is housed within the sample carrier (22), and at least partially photobleaches an area within the portion of the sample carrier (22) by causing the area to fluoresce. By detecting that the area within the portion of the sample carrier (22) has been photobleached, anoutput is generated indicating that at least a portion of the sample carrier (22) is contaminated or that optical measurements cannot be performed on the portion of the sample carrier (22), or the optical measurement device (24) is prevented from performing optical measurements upon a sample portion housed within the given portion of the sample carrier (22).

Description

[0001] Cross References to Related Applications [0002] This application claims priority to U.S. Provisional Patent Application Serial No. 62 / 585,621, filed November 14, 2017, with Yorav-Raphael, entitled "Sample Carrier for Optical Measurements." The applications cited above are hereby incorporated by reference. technical field [0003] Some applications of the presently disclosed subject matter relate generally to sample carriers for optical measurements, and in particular to sample carriers for microscopic measurements performed on body samples. Background technique [0004] In some optical-based methods (eg, diagnostic and / or analytical methods), properties of a biological sample, such as a blood sample, are determined by performing optical measurements. For example, the density of a component (eg, counts of a component per unit volume) can be determined by counting the components within a microscopic image. Similarly, the concentration and / or density of a component c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/03B01L3/00G01N21/64G01N35/00
CPCB01L3/5027B01L9/52G01N21/03G01N21/6456B01L2200/0689B01L2300/0822B01L2300/0877B01L2300/0887G01N2021/0321G01N2021/6482G02B21/0076G02B21/36
Inventor N·尤拉弗-拉斐尔J·J·波拉克S·丽菲·施赖埃尔Y·S·埃谢尔
Owner S D SIGHT DIAGNOSTICS LTD