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Therapies and methods to treat tlr2-mediated diseases and disorders

A mediation and disease technology, applied in chemical instruments and methods, skin diseases, allergic diseases, etc., can solve problems such as atherosclerosis enhancement

Pending Publication Date: 2020-10-30
RGT UNIV OF CALIFORNIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Injection of the TLR2 agonist PAM3CSK4 into cholesterol-fed Ldlr - / - Causes marked enhancement of atherosclerosis in mice

Method used

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  • Therapies and methods to treat tlr2-mediated diseases and disorders
  • Therapies and methods to treat tlr2-mediated diseases and disorders
  • Therapies and methods to treat tlr2-mediated diseases and disorders

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0169] Material. Synthetic standard 1,2-dinnonanoyl-sn-glycero-3-phosphocholine (DNPC), 1-palmitoyl-2-(5-oxopentanoyl)-sn-glycero-3-phosphocholine ( POVPC), 1-palmitoyl-2-glutamyl-sn-glycero-3-phosphocholine (PGPC), 1-palmitoyl-2-azelayl-sn-glycero-3-phosphocholine (PAzPC) , 1-palmitoyl-2-(9-oxo)nonanoyl-sn-glycero-3-phosphocholine (PONPC) and the LPS-free IgM murine natural antibody EO6 were obtained from Avanti Polar Lipids (Alabaster, AL). 1-(palmitoyl)-2-(5-keto-6-octene-diacyl)-3-phosphocholine (KOdiAPC) and 1-palmitoyl-2-(4-keto-dodecyl-3 -ene-diacyl)-sn-glycerol 3-phosphocholine (KDdiAPC) was purchased from Cayman Chemicals (Ann Arbor, MI). All solvents were HPLC grade.

[0170] Generation and characterization of EO6-scFv transgenic mice. Transgenic C57BL / 6 mice expressing the T15 / EO6 idiotype in the form of a single chain variable antibody fragment (termed EO6-scFv-Tg) were generated. Briefly, the cDNAs encoding the variable regions of the heavy and light chains o...

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Abstract

The disclosure provides for methods and treatments of TLR2- mediated diseases and disorders comprising administering an antibody, antibody fragment, or polypeptide that binds to and inhibits the biological activity of oxidized phospholipids.

Description

[0001] Cross References to Related Applications [0002] Pursuant to 35 U.S.C § 119, this application claims priority to Provisional Application Serial No. 62 / 623,276, filed January 29, 2018, the disclosure of which is incorporated herein by reference. [0003] government license [0004] This invention was made with government support under grant number HL088093 awarded by the National Institutes of Health. The government has certain rights in this invention. technical field [0005] The present disclosure provides methods and treatments for TLR2-mediated diseases and disorders comprising administering antibodies, antibody fragments or polypeptides that bind to oxidized phospholipids and inhibit their biological activity. [0006] Incorporated by reference into the sequence listing [0007] Accompanying this file is a sequence listing named "Sequence Listing_ST25.txt" created on January 29, 2019 and having 34,203 bytes machine formatted on an IBM-PC, MS-Windows operat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K16/18C07K16/44
CPCC07K16/2896C07K2317/622A61K2039/505C07K2317/76A61P9/10A61P37/00A61P17/00A61P25/00A61P21/00C07K16/18C07K2317/565A61P37/06A61K9/0019A61K31/60A61K39/39516A61K39/39533C07K2317/51C07K2317/515C07K2317/52C07K2317/524
Inventor 约瑟夫·L·魏茨滕索蒂里奥斯·齐米卡斯X·阙
Owner RGT UNIV OF CALIFORNIA