Composition and method of treatment for dry a.m.d. (age related macular degeneration)

A macular degeneration and composition technology, which is applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc.

Pending Publication Date: 2020-11-03
EYE CO PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] However, Singh noted that AREDS failed to demonstrate that vitamin supplementation slowed its progression to geographic atrophy (GA).

Method used

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  • Composition and method of treatment for dry a.m.d. (age related macular degeneration)
  • Composition and method of treatment for dry a.m.d. (age related macular degeneration)
  • Composition and method of treatment for dry a.m.d. (age related macular degeneration)

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Embodiment

[0121] method

[0122] Animals and Exposure:

[0123] All experiments performed were in accordance with the ARVO Statement - Use of Animals in Ophthalmic and Vision Research. Sprague-Dawley (SD) rats at postnatal 130-160 days were exposed to 1000 lux of bright continuous light (BCL). The rats were born and raised under dim periodic light conditions (12 hours of light: 12 hours of darkness), and the ambient light level was about 5 lux. Animals between 90-150 days postpartum (P) were exposed to BCL. Rats were dark-adapted for at least 15 hours prior to BCL exposure and then transferred to individual cages designed to allow unobstructed light access. There were no shaded areas in the cage; pupil dilation was not performed. BCL exposures always started at 9:00 am and were achieved by using a cool white fluorescent light source (18W, cool white; TFC) positioned above the cage with an intensity of approximately 1000 lux at the bottom of the cage. BCL exposure was continued for ...

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Abstract

A method of treating dry AMD in a subject comprising administering to the subject a therapeutically effective amount of an anti-inflammatory to thereby treat the dry AMD is disclosed. Also disclosed is a pharmaceutical composition comprising a therapeutically effective amount of one or more anti-inflammatory and a pharmaceutically acceptable carrier, diluent or excipient when used to treat dry AMDand use of the pharmaceutical composition for the manufacture of a medicament for the treatment of dry AMD. The one or more anti-inflammatory may comprise one or more of a COX inhibitor, one or moremineralocorticoid or a therapeutically active analogue, derivative, homolog, pharmaceutically acceptable salt or conjugate thereof, one or more glucocorticoid or a therapeutically active analogue, derivative, homolog, pharmaceutically acceptable salt or conjugate thereof, an antileukotrine and / or a leukotriene receptor antagonist. In one embodiment the anti-inflammatory comprises fludrocortisone.

Description

technical field [0001] The present invention relates to a composition and method for treating dry age-related macular degeneration (A.M.D or AMD). More specifically, the present invention relates to compositions and methods for treating dry AMD containing one or more anti-inflammatory drugs. Background technique [0002] It is generally accepted that there is no medical or surgical cure for dry AMD. [0003] Aruna Gorusupudi, Kelly Nelson, and Paul S Bernstein point out that multiple nutrients, such as minerals, vitamins, v-3 (n-3) fatty acids, and various carotenoids, have been consistently associated with a lower risk of AMD. These authors noted that results from the Age-Related Eye Disease Study (AREDS) showed that supplementation with antioxidants (b-carotene and vitamins C and E) and zinc was associated with a reduced risk of AMD progression, AREDS2 A follow-up study aimed to refine the earlier formula, testing the addition of lutein, zeaxanthin, and v-3 fatty acids. ...

Claims

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Application Information

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IPC IPC(8): A61K31/573A61P27/02A61K31/58A61K39/395
CPCA61P27/02A61K31/573A61K31/58A61K9/0019A61K9/0048A61K2300/00A61K38/1866A61K39/395A61K38/179A61K45/06A61K47/38A61K47/26A61K47/02
Inventor P·L·彭福尔德
Owner EYE CO PTY LTD
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