Composition and method of treatment for dry a.m.d. (age related macular degeneration)
A macular degeneration and composition technology, which is applied in the directions of drug combination, pharmaceutical formulation, drug delivery, etc.
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[0123] All experiments performed were in accordance with the ARVO Statement - Use of Animals in Ophthalmic and Vision Research. Sprague-Dawley (SD) rats at postnatal 130-160 days were exposed to 1000 lux of bright continuous light (BCL). The rats were born and raised under dim periodic light conditions (12 hours of light: 12 hours of darkness), and the ambient light level was about 5 lux. Animals between 90-150 days postpartum (P) were exposed to BCL. Rats were dark-adapted for at least 15 hours prior to BCL exposure and then transferred to individual cages designed to allow unobstructed light access. There were no shaded areas in the cage; pupil dilation was not performed. BCL exposures always started at 9:00 am and were achieved by using a cool white fluorescent light source (18W, cool white; TFC) positioned above the cage with an intensity of approximately 1000 lux at the bottom of the cage. BCL exposure was continued for ...
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