Medical device for wound healing and control method of medical device

[0031] In order to make the purpose, technical solution and advantages of the present disclosure clearer, the technical solution of the present disclosure will be clearly and completely described below in conjunction with the accompanying drawings of the present disclosure. Apparently, the described embodiments are some of the embodiments of the present disclosure, not all of them. Based on the described embodiments of the present disclosure, all other embodiments obtained by persons of ordinary skill in the art without creative effort fall within the protection scope of the present disclosure.

[0032] Unless otherwise defined, the technical terms or scientific terms used in the present disclosure shall have the usual meanings understood by those skilled in the art to which the present disclosure belongs. "First", "second" and similar words used in the present disclosure do not indicate any order, quantity or importance, but are only used to distinguish different components. "Comprising" or "comprising" and similar words mean that the elements or items appearing before the word include the elements or items listed after the word and their equivalents, without excluding other elements or items. Words such as "connected" or "connected" are not limited to physical or mechanical connections, but may include electrical connections, whether direct or indirect. "Up", "Down", "Left", "Right" and so on are only used to indicate the relative positional relationship. When the absolute position of the described object changes, the relative positional relationship may also change accordingly.

[0033] To keep the following description of the present disclosure clear and concise, detailed descriptions of known functions and known components are omitted from the present disclosure.

[0034] The first embodiment of the present disclosure provides a medical device for wound healing. The medical device here is a device that directly acts on the patient's wound and has a therapeutic effect, such as a bandage, gauze, etc. The present disclosure is not limited here. In order to fully understand the technical solution of the present disclosure, a bandage is used as an example for description in the present disclosure. like figure 2 As shown, in this embodiment, the patient can be used to indicate the inflammation of the wound by fixing the bandage involved in the embodiment of the present disclosure on the wrist and other parts with wounds, and can release the medicinal solution through the bandage to promote wound healing The bandage for wound healing according to the embodiment of the present disclosure includes a main body part 10, the main body part 10 is arranged on a specific area on the bandage, and the lower surface of the main body part 10 is used to communicate with the wound during use. The wound on the patient's skin is contacted to detect the inflammation information of the patient's wound. In one embodiment, for example, a sensing area can be set on the lower surface to detect the inflammation information of the patient's wound. The size of the sensing area can be It is set according to the use requirements, the size of the wound and other factors; the main body 10 can detect the inflammation of the wound and deform based on the characteristic value of the inflammation.

[0035] Due to the structural deformation of the main body 10 after the inflammation information is detected, the main body 10 can be made of hydrogel, where the hydrogel is a structure that is harmless to the human body, has antibacterial function, and is air-permeable and water-permeable; A kind of preference, the characteristic value here can adopt pH value, and described hydrogel is pH-sensitive hydrogel, and it should be noted that, pH-sensitive hydrogel refers to that the shape of described hydrogel changes with the pH of external environment. The polymer gel that changes with the value change, this kind of gel contains a large number of easily hydrolyzed or protonated acid and base groups, such as shuttle groups and amino groups, the dissociation of these groups is affected by the pH value of the outside world, when When the pH value of the outside world changes, the degree of dissociation of these groups changes accordingly, resulting in a change in the concentration of internal and external ions. In addition, the dissociation of these groups will also destroy the corresponding hydrogen bonds in the gel, making the crosslinking points of the gel network Decrease, resulting in changes in the gel network structure, resulting in changes in the volume of the hydrogel.

[0036] Preferably, the technical solution of the embodiment of the present disclosure adopts a cationic sensitive hydrogel, and the ionizable group is generally derived from the weakly basic group amine (-NH 2), the swelling properties of this type of hydrogel are related to the degree of protonation of the amine group on the molecular chain. This kind of cation-sensitive hydrogel is generally in a shrinking state in an alkaline environment with a high pH, ​​while in an acidic environment with a low pH, the amine group is protonated, and the electrostatic repulsion between molecules is enhanced. The volume of the hydrogel will increase, the more the number of protonated amine groups in the hydrogel, the higher the swelling degree of the hydrogel, resulting in a larger volume, when the electrostatic repulsion between cations and the resilience of the grid reach a balance , the hydrogel reaches the maximum volume; and when the PH value returns to alkaline, the hydrogel begins to shrink due to the reduced degree of protonation and the electrostatic repulsion force is smaller than the resilience of the grid.

[0037] Therefore, this type of pH-sensitive hydrogel can shrink and deform in an alkaline environment or a high pH environment, and expand and deform in an acidic environment or a low pH environment; wherein, the pH value of normal human skin is weakly acidic ( For example, the pH value is in the range of 5.5-6), however, when the wound is inflamed, the pH value of the wound will rise to alkaline (for example, the pH value rises to about 7.4), when the skin wound is treated and heals normally Later, due to tissue regeneration and reorganization, the pH value of the wound will gradually decrease and return to acidity. In this way, the lower surface of the hydrogel is in contact with the patient's wound, and the pH value reflecting inflammation information at the wound can be detected through the deformation state of the hydrogel.

[0038] Further, a first accommodating part is provided in the main body part 10, and the first accommodating part is used for accommodating medicinal liquid with functions such as sterilization and treatment. The accommodating part ruptures with the structural deformation of the main body part 10 to release the medicinal liquid, and the released medicinal liquid penetrates through the lower surface of the main body part 10, for example, through the sensing area, and is transported to the surface of the patient's wound. Sterilizes and promotes wound healing.

[0039] Further, in order to facilitate the rupture of the first containing part along with the deformation of the main body part 10 to release the medicinal liquid, in one embodiment, the first containing part may be a plurality of capsules arranged in a certain order 20. A plurality of capsules 20 can be suspended in the main body 10, for example, can be suspended in the hydrogel, the distance between adjacent capsules 20 is less than a predetermined threshold, and each capsule 20 contains a medicinal liquid, and when the main body 10 shrinks and deforms, contact and compression occur between a plurality of the capsules 20 and cause the capsules 20 to rupture to release the medicinal liquid. In this way, when the main body 10 contacts the patient's wound and shrinks and deforms, the plurality of capsules 20 in the main body 10 are broken under the action of mutual accumulation inside the main body 10 so that the capsules 20 The medicinal solution in the body part 10 is released and seeps out from the position where the lower surface of the main body part 10 is in contact with the patient's skin to the patient's wound to achieve disinfection and treatment of the wound.

[0040] In the embodiment of the present disclosure, after the inflammation information of the patient's wound is detected on the lower surface of the main body part 10, it can also be prompted to the doctor or patient in time. 30, the conductive part 30 is electrically connected in series with the prompting device, specifically, both ends of the conductive part 30 are respectively connected to the prompting device through wires, and the conductive part 30 is in the normal state of the main body part 10 In the disconnected state, when the main body 10 detects inflammation information and undergoes structural deformation, the conductive part 30 can conduct based on the structural deformation of the main body 10 to form a series circuit with the prompting device In this way, when the conductive part 30 is turned on, the prompting device can prompt the patient or the doctor for the inflammation information of the wound, specifically, the prompting device includes a power supply and a light emitting diode, and the power supply uses In order to supply power to the conductive part 30, the light emitting diode is used for light prompting.

[0041] Further, the conductive part 30 is arranged above the main body part 10, specifically, the conductive part 30 is connected to the upper surface of the main body part 10 through an insulating layer 31, and the insulating layer 31 is used to connect the The conductive part 30 is insulated from the main body part 10. In one embodiment, in order to facilitate the conduction of the conductive part 30 after the structural deformation of the main body part 10, the conductive part 30 is arranged separately. A plurality of conductive particles 32, the distance between adjacent conductive particles 32 is less than a predetermined threshold, when the main body part 10 is in a normal state or expanded and deformed, the plurality of conductive particles 32 When the main body part 10 shrinks and deforms, the plurality of conductive particles 32 can contact each other through shrinkage deformation, so as to conduct with each other, so that the conductive part 30 conducts Pass. In one embodiment, when the conductive part 30 adopts a plurality of conductive particles 32 , the conductive particles 32 located at the outermost sides on both sides are respectively connected in series with the prompting device through wires to form a series loop. Here, by arranging a plurality of conductive particles 32, not only can the conductive particles 32 contact each other when the main body part 10 shrinks and deforms, so that the conductive part 30 can form a conduction, but also prevent the The partial deformation of the hydrogel causes false contact between some of the conductive particles 32 to generate a false alarm.

[0042] When the bandage according to the embodiment of the present disclosure is fixed at the wound site of the patient, the lower surface of the main body part 10 is in contact with the wound and the inflammation information of the wound is detected. Structural deformation, for example, contraction deformation occurs because the wound is alkaline and has a high pH value. At this time, the conductive part 30 forms a conduction to make the prompting device work, such as making the light-emitting diode in the prompting device light up, It can remind patients or doctors that the wound is currently in the inflammatory response stage. For example, it can be judged whether the wound is inflamed or infected according to the length of time and frequency; when the inflammation in the wound is eliminated, the wound heals normally or tissue regeneration is completed, the pH value of the wound decreases. , the main body part 10 returns to a normal state and realizes expansion and deformation, for example, the acidity is restored due to the low pH value of the wound, so that the main body part 10 expands and deforms, so that the conductive part 30 is disconnected, for example, the conductive particles 32 are separated from each other causing the circuit to be disconnected, the LEDs are extinguished, and the alarm is cleared, indicating that the wound is healing and regenerating normally.

[0043] In this way, when the main body part 10 touches the patient's wound and undergoes structural deformation, not only the conductive part 30 forms a conduction and prompts the patient and the doctor with inflammation information through the prompting device, but the main body part 10 The multiple capsules 20 in the body part 10 are crushed under the mutual pressing action inside the body part 10 so that the medicinal liquid in the capsules 20 is released at one time and contacts the patient's skin from the lower surface of the body part 10 The position seeps into the patient's wound to achieve disinfection and treatment of the wound.

[0044] The embodiment of the present disclosure can detect the inflammation of the patient in real time, and automatically replenish the medicine at one time based on the inflammation situation, which is beneficial to eliminate wound inflammation, accelerate wound healing, reduce the risk of wound infection, and can also monitor the wound healing status in time and provide timely feedback Alert physicians and patients.

[0045] The second embodiment of the present disclosure provides a medical device for wound healing. On the basis of the first embodiment above, in order to better control the dosage and realize multiple administrations, in addition to including the above-mentioned inflammation Functions and structures such as information detection and drug release, ie at least including the main body 10 and the first accommodating portion, further increase the on-demand drug delivery function and structure based on the microneedle structure.

[0046] like image 3 As shown, the second embodiment of the present disclosure provides a medical device for wound healing. The medical device here takes a bandage as an example, which includes a main body 10, which is arranged on a specific area on the bandage. The lower surface of the main body 10 is used to contact the wound on the patient's skin during use to detect inflammation information of the patient's wound. In one embodiment, for example, a sensing area can be set on the lower surface In order to detect the inflammation information of the patient's wound, the size of the sensing area can be set according to the needs of use, the size of the wound and other factors; the main body part 10 undergoes structural deformation after detecting the inflammation information.

[0047] Due to the structural deformation of the main body 10 after the inflammation information is detected, the main body 10 can use hydrogel, where the hydrogel is a structure that is harmless to the human body, has an antibacterial function, and has an air-permeable and water-permeable structure; Preferably, the hydrogel is a pH-sensitive hydrogel, and this hydrogel is prone to shrinkage deformation in an alkaline environment or a high pH environment, and is prone to expansion deformation in an acidic environment or a low pH environment, wherein , the pH value of normal skin is weakly acidic (for example, the pH value is in the range of 5.5-6), however, when the wound is inflamed, the pH value of the wound will rise to alkaline (for example, the pH value is around 7.4), When the normal healing tissue of the skin regenerates and reorganizes, the pH value will gradually decrease and return to acidity. In this way, by contacting the lower surface of the hydrogel with the patient's wound, the pH value reflecting inflammation information at the wound can be detected, so that deformation occurs by detecting the pH value.

[0048] Of course, the main body part 10 also includes a first accommodating part, a conductive part 30 , a prompting device, etc., and the above structures are the same as those in the first embodiment.

[0049] In addition, a second storage part is also provided in the main body part 10, and the second storage part is used for containing the medical liquid with functions of sterilization and treatment, etc., and the second storage part can be divided into batches under certain conditions. The released medical solution penetrates through the lower surface of the main body 10, for example, through the sensing area, and is transported to the surface of the patient's wound to sterilize and promote wound healing.

[0050] At least one drug delivery part 40 is also provided on the upper surface of the main body part 10, and the second accommodating part is provided corresponding to the drug delivery part 40 in the main body part 10. Preferably, the second accommodating part Will not be broken due to the deformation of the main body part 10, for example, when the second receiving part adopts capsules 20, the capsules 20 are separated from each other by a relatively long distance and are independent of each other, so that even when the When the main body part 10 shrinks and deforms due to the change of the pH value, the second containing parts will not be crushed each other, so that the second containing parts will not break with the deformation of the main body part 10 .

[0051] The drug delivery unit 40 can realize drug delivery in batches after the main body 10 detects the inflammation information of the wound, specifically, the drug delivery unit 40 includes an electrostrictive device 41, and the electrostrictive device Electrode pairs 42 are arranged on both sides of 41, and a microneedle array 43 is arranged below the electrostrictive device 41, and the microneedle array 43 is in contact with the upper surface of the main body 10. Further, the electrode pair 42 It is disposed on the main body portion 10 through an insulating layer 44 . When a voltage is applied to the electrode pair 42 from the outside, the electrostrictive device 41 will stretch and drive the microneedle array 43 to penetrate the main body 10 and pierce the The second containing part, so as to release the medicinal liquid contained in the second containing part, which has the functions of sterilization and treatment, and the released medicinal liquid passes through the lower surface of the main body part 10, for example, through the sensing area on the lower surface Penetrates and delivers to the patient's wound surface to kill bacteria and promote wound healing. Here, each of the drug delivery parts 40 can be individually controlled, for example, the on-off of each pair of the electrode pairs 42 can be individually controlled, so that the microneedle array 43 of each drug delivery part 40 can be individually controlled to puncture the corresponding The second containing part, so that the drug solution in any of the drug administration parts 40 can be released as required, so that the batch drug can be realized and the drug dose can be guaranteed.

[0052] Further, the technical solution according to the first embodiment of the present disclosure can realize the monitoring and prompting of inflammation information and one-time drug administration, and the technical solution according to this embodiment can also realize batch-by-batch and gradual Drug administration, based on the medical device involved in this embodiment, can realize the above-mentioned functions of one-time drug liquid release and multiple drug administration at the same time. ground, such as Figure 4As shown, the lower surface of the main body 10 is divided into different regions, for example, at least one first region 100 and at least one second region 200, the first region 100 can be an automatic drug delivery region, and the automatic drug delivery The first accommodating part, the conductive part 30 and the prompting device involved in the first embodiment can be set in the part of the main body part 10 of the zone, so that after the inflammation information of the wound is detected through the main part 10 , direct one-time administration through the first containing part, the second area 200 may be an on-demand administration area, and the part of the main body part 10 of the on-demand administration area may be provided with the The second receiving part and the drug delivery part 40, through the cooperation of the drug delivery part 40 and the second receiving part, continuous drug delivery and multiple drug delivery can be realized according to the condition of the wound, which expands the drug delivery function.

[0053] Further, in the case of setting a plurality of the first regions 100 and the second regions 200, the first regions 100 and the second regions 200 can be arranged alternately so as to target different parts of the wound Administer as needed.

[0054] Of course, further, since the prompting device is provided on the first area 100 of the main body 10, only when the prompting devices in all the first areas 100 give prompts, for example, light-emitting diodes are all lit, can the said prompting device be confirmed. The main body part 10 detects the inflammation information of the wound, so as to prevent the misconduction of the conductive part 30 caused by the deformation caused by the external force during installation and use, for example, the misconduction caused by the mutual contact between the conductive particles 32, Improved detection accuracy for inflammation information.

[0055] The embodiment of the present disclosure can detect the inflammation of the patient in real time, and can automatically supplement the medicine at one time or in batches based on the inflammation situation, which is beneficial to eliminate wound inflammation, accelerate wound healing, reduce the risk of wound infection, and can also monitor the wound in time Healing status, timely feedback to remind doctors and patients.

[0056] The third embodiment of the present disclosure provides a control method for a medical device. In order to make the medical device involved in the embodiment of the present disclosure more intelligent, the above-mentioned first embodiment and/or the second embodiment are adopted in this embodiment In the case of a medical device with wound inflammation detection and automatic drug delivery function or batch drug delivery function, the control function and display function can also be added, so as to implement the technical solution in the second embodiment respectively through control.

[0057] Wherein, in order to enable the automatic drug delivery function or the batch drug delivery function to be controlled, as an alternative to the wires and prompting devices in the first embodiment and/or the second embodiment, at least one The sensor, the sensor here is connected with the conductive part 30 and the control device, and it can adopt RFID radio frequency identification sensor, which does not need power supply, which increases product safety and portability.

[0058] On the basis of the second embodiment of the present disclosure, when the control device in this embodiment detects the characteristic value of the patient's wound inflammation, such as the pH value, it can perform one-time administration and/or batches based on the characteristic value administration, such as Figure 5 As shown, its control methods include:

[0059] S101. Detect a first characteristic value of wound inflammation, and perform one-time drug administration based on the first characteristic value.

[0060] In this step, the first characteristic value may be the first pH value of inflammation, and the first pH value at the wound is monitored in real time through, for example, the lower surface of the main body part 10 using hydrogel, when the first pH value Low is acidic, the main body 10 is stretched, and the sensor will not send a signal. When wound inflammation is detected, the first PH value at the wound rises to be alkaline, and the main body 10 shrinks and deforms, so that For example, the conductive part 30 of the conductive particle 32 is used to conduct, and the sensor receives the conduction signal and sends a control signal. The control signal can preferably be received through a signal amplifier and wireless/interface transmission. The first containing portion of 20 is squeezed and ruptured to release the drug, thereby performing one-time administration, and continuing to monitor the pH value again in real time;

[0061] S102. Detect the second characteristic value of the wound inflammation, and when the second characteristic value is greater than the first threshold, after waiting for a predetermined time, detect the third characteristic value of the wound inflammation and compare it with the second threshold ;

[0062] In this step, after receiving the sensor signal, it will be determined according to the number of signals sent by the sensor whether the conductive part 30 is falsely touched or whether the characteristic value such as the pH value has actually increased. value rises, then continue to detect the second characteristic value of the wound, such as the PH value, and at the same time, an instruction to display an alarm can be sent to the display device, if the second characteristic value is greater than the first threshold value, then wait for a predetermined time, The predetermined time here is the effective time of the medicinal solution in performing one-time administration. After waiting for the effective time of the medicinal solution, the third characteristic value of the wound is detected again and compared with the second threshold value.

[0063] S103. When the third characteristic value is greater than the second threshold, perform batch administration.

[0064] In this step, if the third characteristic value is greater than the second threshold, a control signal is sent to the drug delivery unit 40 to instruct the application of a voltage signal to the electrode pair 42, and when the drug delivery unit 40 receives the instruction signal, A voltage signal is applied to a corresponding number of the electrode pairs 42, so that the corresponding electrostrictive device 41 is extended, and the microneedle array 43 is driven to pierce the second containing portion, thereby releasing the drug.

[0065] The embodiment of the present disclosure can detect the inflammation of the patient in real time, and can automatically supplement the medicine at one time or in batches based on the inflammation situation, which is beneficial to eliminate wound inflammation, accelerate wound healing, reduce the risk of wound infection, and can also monitor the wound in time Healing status, timely feedback to remind doctors and patients.

[0066] The fourth embodiment of the present disclosure provides a control device for a medical device, which is used to implement the control method in the above-mentioned embodiments, and the specific control method will not be described again. The control device includes

[0067] The first execution module is used to detect the first characteristic value of wound inflammation, and execute one-time drug administration based on the first characteristic value.

[0068] A judging module that detects a second characteristic value of the wound inflammation, and when the second characteristic value is greater than the first threshold, after waiting for a predetermined time, detects a third characteristic value of the wound inflammation and compares it with the second threshold Compare.

[0069] A second execution module, configured to perform batch administration when the third characteristic value is greater than the second threshold.

[0070] The embodiment of the present disclosure can detect the inflammation of the patient in real time, and can automatically supplement the medicine at one time or in batches based on the inflammation situation, which is beneficial to eliminate wound inflammation, accelerate wound healing, reduce the risk of wound infection, and can also monitor the wound in time Healing status, timely feedback to remind doctors and patients.

[0071] Furthermore, while exemplary embodiments have been described herein, the scope includes any and all implementations having equivalent elements, modifications, omissions, combinations (eg, cross-cutting aspects of various embodiments), adaptations, or changes based on this disclosure. example. Elements in the claims are to be interpreted broadly based on the language employed in the claims and are not limited to examples described in this specification or during the practice of the application, which examples are to be construed as non-exclusive. It is therefore intended that the specification and examples be considered as illustrations only, with a true scope and spirit being indicated by the following claims, along with their full scope of equivalents.

[0072] The above description is intended to be illustrative rather than restrictive. For example, the above examples (or one or more aspects thereof) may be used in combination with each other. For example, other embodiments may be used by those of ordinary skill in the art upon reading the above description. Additionally, in the above Detailed Description, various features may be grouped together in order to simplify the disclosure. This is not to be interpreted as intending that an unclaimed disclosed feature is essential to any claim. Rather, inventive subject matter may lie in less than all features of a particular disclosed embodiment. Thus, the following claims are hereby incorporated into the detailed description as examples or embodiments, where each claim stands on its own as a separate embodiment, and it is contemplated that these embodiments may be combined with each other in various combinations or permutations. The scope of the invention should be determined with reference to the appended claims, along with the full scope of equivalents to which such claims are entitled.

[0073] The above embodiments are only exemplary embodiments of the present invention, and are not intended to limit the present invention, and the protection scope of the present invention is defined by the claims. Those skilled in the art can make various modifications or equivalent replacements to the present invention within the spirit and protection scope of the present invention, and such modifications or equivalent replacements should also be deemed to fall within the protection scope of the present invention.