Traditional Chinese medicine composition, preparation method and application of synergistic chemotherapy drugs for treating tumor-bearing mice

Abstract

A traditional Chinese medicine composition, preparation method and application for treating tumor-bearing mice with synergistic chemotherapeutic drugs. A traditional Chinese medicine prescription for treating tumor-bearing mice with synergistic chemotherapeutic drugs, comprising: Radix Astragali, Radix Ginseng, Rehmannia Radix Rehmanniae Radix Radix Radix Radix Radix Astragali, Radix Ginseng, Rhizoma Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Astragali, Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Radix Paeoniae Alba, and Rhizoma Chuanxiong Rhizoma Rhizoma Chuanxiong. The parts by weight are 10-15 parts, the parts by weight of the Rehmannia glutinosa are 12-15 parts, the parts by weight of the Angelica sinensis are 10-12 parts, and the parts by weight of the Radix Paeoniae Alba are 8-15 parts 12 parts, the parts by weight of the Rhizoma Chuanxiong are 10-12 parts. The invention is used for treating tumor-bearing mice in cooperation with chemotherapeutic drugs.

Description

technical field [0001] The invention relates to a traditional Chinese medicine prescription, preparation method and application for treating tumor-bearing mice with synergistic chemotherapy drugs. Background technique [0002] Melanoma is a malignant tumor derived from melanocytes. It is a common skin tumor in clinical practice. It can occur in any anatomical site where melanocytes exist, and has biological characteristics such as high degree of deterioration, easy metastasis, and poor prognosis. Caucasians are a group with a high incidence of melanoma. Although my country is not a country with a high incidence of melanoma, in recent years, there are about 20,000 new cases of melanoma in my country every year, and the trend is increasing year by year. The mortality rate of melanoma ranks first among skin malignancies, and the 5-year survival rate is less than 5%, which has a huge impact on patients' health and social economy. At present, two methods of immunotherapy and tar...

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Problems solved by technology

[0004] At present, many studies have shown that Shengbai Decoction can alleviate leukopenia caused by radiotherapy and chemotherapy for malignant tumors, such as Yiqi Shengbai Decoction in the treatment of leukopenia after chemotherapy for non-small cell lung cancer [Xiang Wei, Xie Yutao, Zhang Hui. Yiqi Shengbai Decoction Clinical efficacy of treatment of leukopenia after chemotherapy of non-small cell lung cancer. Modern Oncology, 2019, 27(12): 2117-2121.], Fuzheng Shengbai Decoction in the treatment of leukopenia after chemotherapy of breast cancer [Dong Wanbin, Xi Jiangwei, Liu Bin, Su Xinjing .Observation on the clinical effect of Fuzheng Shengbai Decoction on the adverse reactions of postoperative chemotherapy of breast cancer. China Maternal and Child Health Care, 2016,31(14):2827-2829.] etc., the current research on Shengbai Decoction is mostly focused on the treatment of malignant tumors after chemotherapy Although there are many researches on Shengbai decoction for the treatment of leukopenia, the ingredients of each Shengbai decoction are not the same due to the inconsistent curative effect standards of traditional Chinese medicine decoctions and different doctors' experience.

[0005] Although many studies have shown that Shengbai Decoction can alleviate the leukopenia caused by chemotherapy for various malignant tumors, so far, there is no report that Shengbai Decoction can synergize with cyclophosphamide to have anti-tumor activity

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