A kind of preparation method of fused ring compound
A compound and fused ring technology, applied in the field of the preparation of fused ring compounds, can solve the problems of poor compatibility of fused ring compounds, cumbersome preparation route steps, limited applicability of substrates, etc., and achieve the effect of good compatibility and excellent regioselectivity
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[0116] Example 1 examine the substrate compatibility
[0117]
[0118] In the dry sealing tube, the protection of the mule, add 3.4mg PD (OAC) respectively 2 , 16.2mg DPEPHOS, 77.4mg 1A (0.3mmol), 47.1 μL 2A (0.45mmol), 82.8mg K K 2 CO 3 , 1.5ml dioxane, heating to 130 ° C, stirring for 5 hours. Downside to room temperature, concentration, residual objects are based on orthopedic anxane as the cylinder layer, collecting product bands, obtained 3AA white solid 65mg, and the yield is 85 %.
[0119] 1 H nmr (400MHz, CDCL 3 ) Δ8.77 (d, j = 8.0Hz, 1H), 8.72 (d, j = 8.4Hz, 1H), 7.92-7.88 (m, 2H), 7.68-7.59 (m, 4H), 7.56-7.43 (m m , 6h) PPM; EI-MS M / Z ( %): 254.1 (M + );
[0120] At 130 ° C, keep the compound of 2A unchanged and change the substrate 1A. Other conditions are the same as the above embodiments. The product and yield are as follows 1:
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[0122]
[0123]
[0124]
[0125] At 130 ° C, keep the compound 1A unchanged and change the substrate 2A. Other conditions ...
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