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Application of prpf6 in the treatment of prostate cancer and castration-resistant prostate cancer

A technology for prostate cancer, therapeutics, applied in the field of biomedicine

Active Publication Date: 2022-02-15
中国医科大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the role of PRPF6 in prostate cancer has not been reported so far. Therefore, it is of great significance to study the mechanism and biological function of PRPF6 as a co-regulator in prostate cancer and castration-resistant prostate cancer.

Method used

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  • Application of prpf6 in the treatment of prostate cancer and castration-resistant prostate cancer
  • Application of prpf6 in the treatment of prostate cancer and castration-resistant prostate cancer
  • Application of prpf6 in the treatment of prostate cancer and castration-resistant prostate cancer

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Embodiment Construction

[0030] The present invention will be described in further detail below in conjunction with the accompanying drawings and embodiments. The experimental method that does not indicate specific condition in the embodiment, usually according to conventional conditions, such as the conditions described in textbooks and experimental guides, or according to the conditions suggested by the manufacturer, is well known or easy to know by those of ordinary skill in the art, the following implementation Examples are only preferred embodiments of the present invention, and do not limit the present invention. For those skilled in the art, the present invention can have various modifications and changes, and within the spirit and principles of the present invention, any modifications made , equivalent replacements, improvements, etc., should all be included within the protection scope of the present invention.

[0031] Example.

[0032] 1. Preparation of inhibitors.

[0033] According to PR...

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Abstract

The invention belongs to the technical field of biomedicine, and relates to the application of PRPF6 in the treatment of prostate cancer and castration-resistant prostate cancer. Application of the PRPF6 targeting inhibitor in the preparation of drugs and pharmaceutical compositions for preventing or treating prostate cancer and castration-resistant prostate cancer. The present invention finds for the first time that PRPF6 can promote the progression of prostate cancer and castration-resistant prostate cancer, that PRPF6 is more highly expressed in prostate cancer tissues with higher malignancy, and inhibiting PRPF6 can significantly inhibit the occurrence and development of prostate cancer and castration-resistant prostate cancer. Role of PRPF6 in resistance to treatment in prostate cancer and castration-resistant prostate cancer. It is found that PRPF6 has a potential function of drug resistance in prostate cancer and castration-resistant prostate cancer endocrine drugs, and the preparation of small molecule inhibitors of PRPF6, siRNA or the discovery of inhibition of PRPF6 transcription to generate miRNA can be used to treat clinical prostate cancer and castration-resistant prostate cancer. The invention provides a new idea and a new target for treating prostate cancer and castration-resistant prostate cancer.

Description

technical field [0001] The invention belongs to the technical field of biomedicine, and relates to the application of PRPF6 in the treatment of prostate cancer and castration-resistant prostate cancer. Background technique [0002] Prostate cancer (PCa) is a malignant tumor that occurs in male prostate tissue. In western countries, its mortality rate ranks second among various cancers, and its incidence rate in China is also on the rise in recent years. Androgen deprivation therapy is an important early treatment for prostate cancer, which can usually inhibit tumor progression, but after a period of treatment, some patients will develop castration-resistant prostate cancer (CRPC). After the transformation of prostate cancer into castration-resistant prostate cancer, androgen deprivation therapy will lose its effectiveness, and the possibility of tumor metastasis will increase significantly. However, there is still a lack of effective strategies and means to combat castrati...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/713A61P35/00
CPCA61K31/713A61P35/00
Inventor 赵越王春玉刘伟林琳王胜利邹仁龙孙洪邈曾凯
Owner 中国医科大学
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