Anti-bacterial hydrophilic urethral catheter

A urinary catheter and hydrophilic technology, applied in catheters, coatings and other directions, can solve the problems such as the inability to effectively improve the tissue compatibility of the urinary catheter, the failure to improve the hydrophilicity of the urinary catheter, and the threat to the life, health and safety of patients, etc. Achieve the effect of preventing urinary tract infection, reducing urethral mucosal damage, and reducing urinary tract infection

Inactive Publication Date: 2020-12-08
湖南博隽生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the urinary catheters used in medicine are made of natural rubber, silicone rubber or polyvinyl chloride. These catheters are more or less prone to urinary tract infections due to the compatibility of the materials with the urethra. And allergies, the surface particles are thicker and have loss of lubrication, which can easily induce the growth of bacterial biofilms, and easily cause burning pain in patients during the process of passing through the urethra and entering the bladder, and even cause inflammation due to damage to the mucous membrane. It brings inconvenience to medical care and nursing, and also causes unnecessary pain to patients. At the same time, it increases the hidden danger of medical disputes, and even threatens the life, health and safety of patients.
[0004] In order to improve the bacteriostasis and lubricity of the urinary catheter, researchers have made a lot of efforts. The method to improve the bacteriostasis is mainly to spray a layer of hydrosol or antibiotics containing bacteriostatic agents or antibiotics on the outer layer of the rubber catheter. Lubricating glue, this method is easy to cause the coating material to fall off in the follow-up operation process, and has no actual clinical application; in addition, it has been realized that the urinary catheter carries the bacteriostatic agent by adding the bacteriostatic agent to the surface treatment solution of the urinary catheter However, the same method cannot effectively improve the histocompatibility of the urinary catheter and increase the stability of the antibacterial agent
The technical measures to improve lubricity are mainly to coat lubricants such as paraffin oil or complexed iodine on the surface of the urinary catheter, but paraffin oil is not absorbed by the mucous membrane, and it is easy to cause other diseases. Partial wiping does not achieve a comprehensive lubrication effect. These methods do not improve the hydrophilicity of the urinary catheter, increase the difficulty of intubation, and increase the pain of the patient

Method used

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  • Anti-bacterial hydrophilic urethral catheter

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] A medical catheter, comprising a catheter body and a coating coated on the surface of the catheter body, the catheter body is made of 1-(4,5-dimethyl-1-vinyl-1H -pyrrol-2-yl)-2,2,2-trifluoroethanone, 2-trimethylsilyloxy-1,1,1,5,5,5-hexafluoro-2-pentene-4 -one, silver (6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionate), (5R)-5-[(1E, 3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-butenyl]-1-[6-(1H-tetrazol-5-yl)hexyl]-2-pyrrolidone formed by copolymerization Copolymer, made of polyurethane and 1-[3-(triethoxysilyl)propyl]-1H-pyrrole-2,5-dione modified fullerene; the coating on the surface of the catheter body It is made of raw materials 1,1-methylenebis[3-(2-hydroxyethyl)-2-pyrrolidone], 1,1,3,3-tetramethyl-1,3-bis-[2-[7 -Oxidized bicyclo[4.1.0]hept-3-yl]ethyl]disiloxane and polylactic acid are prepared by chemical reaction.

[0037] The preparation method of the catheter body comprises the following steps:

[0038] Ⅰ 1-(4,5-Dimethyl-1-vinyl-1H-pyrrol-2-yl)-2,2,2-triflu...

Embodiment 2

[0045] A medical catheter, comprising a catheter body and a coating coated on the surface of the catheter body, the catheter body is made of 1-(4,5-dimethyl-1-vinyl-1H -pyrrol-2-yl)-2,2,2-trifluoroethanone, 2-trimethylsilyloxy-1,1,1,5,5,5-hexafluoro-2-pentene-4 -one, silver (6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionate), (5R)-5-[(1E, 3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-butenyl]-1-[6-(1H-tetrazol-5-yl)hexyl]-2-pyrrolidone formed by copolymerization Copolymer, made of polyurethane and 1-[3-(triethoxysilyl)propyl]-1H-pyrrole-2,5-dione modified fullerene; the coating on the surface of the catheter body It is made of raw materials 1,1-methylenebis[3-(2-hydroxyethyl)-2-pyrrolidone], 1,1,3,3-tetramethyl-1,3-bis-[2-[7 -Oxidized bicyclo[4.1.0]hept-3-yl]ethyl]disiloxane and polylactic acid are prepared by chemical reaction.

[0046] The preparation method of the catheter body comprises the following steps:

[0047] Ⅰ 1-(4,5-Dimethyl-1-vinyl-1H-pyrrol-2-yl)-2,2,2-triflu...

Embodiment 3

[0054] A medical catheter, comprising a catheter body and a coating coated on the surface of the catheter body, the catheter body is made of 1-(4,5-dimethyl-1-vinyl-1H -pyrrol-2-yl)-2,2,2-trifluoroethanone, 2-trimethylsilyloxy-1,1,1,5,5,5-hexafluoro-2-pentene-4 -one, silver (6,6,7,7,8,8,8-heptafluoro-2,2-dimethyl-3,5-octanedionate), (5R)-5-[(1E, 3R)-4,4-difluoro-3-hydroxy-4-phenyl-1-butenyl]-1-[6-(1H-tetrazol-5-yl)hexyl]-2-pyrrolidone formed by copolymerization Copolymer, made of polyurethane and 1-[3-(triethoxysilyl)propyl]-1H-pyrrole-2,5-dione modified fullerene; the coating on the surface of the catheter body It is made of raw materials 1,1-methylenebis[3-(2-hydroxyethyl)-2-pyrrolidone], 1,1,3,3-tetramethyl-1,3-bis-[2-[7 -Oxidized bicyclo[4.1.0]hept-3-yl]ethyl]disiloxane and polylactic acid are prepared by chemical reaction.

[0055] The preparation method of the catheter body comprises the following steps:

[0056] Ⅰ 1-(4,5-Dimethyl-1-vinyl-1H-pyrrol-2-yl)-2,2,2-triflu...

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Abstract

The invention discloses an anti-bacterial hydrophilic urethral catheter which comprises a urethral catheter body and a coating coated on the surface of the urethral catheter body. The urethral catheter body is prepared from a fluorine-silicon material copolymer, polyurethane and 1-(3-triethoxysilylpropyl)-1H-pyrrole-2,5-diketone modified fullerene, wherein the coating on the surface of the urethral catheter body is prepared from 3-(2-hydroxyethyl)-1-[[3-(2-hydroxyethyl)-2-oxopyrrolidin-1-yl]methyl]pyrrolidin-2-one, Bis[2-(3,4-epoxycyclohexyl)ethyl]tetramethyldisiloxane and polylactic acid through a chemical reaction. The prepared anti-bacterial hydrophilic urethral catheter is excellent in comprehensive performance, has a continuous anti-bacterial effect, is excellent in surface hydrophilic lubrication, flexibility and comfort, and is easy to insert.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a medical catheter and a preparation method thereof. Background technique [0002] In recent years, general paralysis or hemiplegia caused by brain diseases such as stroke or spinal injury, non-neurogenic bladder diseases such as obstruction caused by prostatic hypertrophy, urethral stricture or postoperative urinary retention, and spina bifida or multiple The number of patients with neurogenic bladder diseases such as sexual sclerosis is increasing year by year due to reasons such as an increase in the elderly population and an increase in traffic accidents and industrial accidents. These patients need continuous urinary catheterization to empty their bladders during treatment, and medical catheters are needed during catheterization. Medical catheters are a safe, effective, and compatible tool for diagnosis and treatment. The application is becoming more and more extens...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M25/00A61L29/06A61L29/08A61L29/14
CPCA61L29/085A61L29/14A61L2420/02A61L2420/06C08F226/06C08F230/085C08L83/10C08L75/04
Inventor 朱露晶邓生卫
Owner 湖南博隽生物医药有限公司
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